All Gene Supplementary Material - Additional samples removed.

Load Libraries

# libraries used for analysis
library(edgeR)
library(limma)
library(quadprog)
library(ruv)

# libraries required for graphics
library(ggplot2)
library(reshape2)
library(EDASeq)
library(RColorBrewer)
library(VennDiagram)
library(data.table)
library(dplyr)
library(stringr)
library(knitr)
library(pheatmap)


wd = "./"
colors <- c("#0571b0", "#ca0020")

Load our data

We first produce a matrix of read counts after aligning to both the Human and Plasmodium falciparum 3D7 reference genome. Subread’s featureCounts program is then used to allocate reads to gene features using the gff file PlasmoDB-12.0_Pfalciparum3D7.gff from PlasmoDB. For both Subread programs the default options are used.

setwd(wd)
# # Next subreads featureCounts was used to allocate reads to genes. This
# was saved for re-use files <-
# Sys.glob('/home/users/allstaff/tonkin-hill.g/all_gene_analysis/alignment/*.sam')
# fc_genes_aligned_w_Pfhuman_withoutVivax <- featureCounts(files, annot.ext
# = './data/PlasmoDB-12.0_Pfalciparum3D7.gff' , isPairedEnd=TRUE,
# isGTFAnnotationFile=TRUE, GTF.attrType='ID', GTF.featureType='gene' ,
# nthreads=15)

# Load gene ID mappings which we use later on.
geneID_mappings <- fread("./data/geneID_mappings.txt", data.table = FALSE, stringsAsFactors = FALSE)
trim <- function(x) gsub("^\\s+|\\s+$", "", x)
s <- str_split(as.character(geneID_mappings$`[Previous ID(s)]`), ",")
geneID_mappings <- data.frame(current = rep(geneID_mappings$`[Gene ID]`, sapply(s, 
    FUN = length)), old = unlist(s))
geneID_mappings$old <- str_trim(geneID_mappings$old)

# Load read counts (if featureCounts has been run previously)
load("./data/fc_genes_with_all_samples_aligned_human_Pf_WithOutVivax_subread_uH.RData")
fc2 <- fc_genes_aligned_w_Pfhuman_withoutVivax
t <- fc2$counts

# Rename samples to something more sensible colnames(t) <-
# gsub('alignment\\.sam','',colnames(t)) colnames(t) <-
# gsub('.*vivax\\.','',colnames(t)) colnames(t) <- gsub('_S.*','',
# colnames(t))
fc2$counts <- t

x <- DGEList(counts = fc2$counts, genes = fc2$annotation)

Initial filter

We next filter out genes that do not have sufficient coverage across our samples for reliable estimates to be made.

setwd(wd)
before <- nrow(x$counts)
keep <- rowSums(cpm(x) > 2) >= 10
x <- x[keep, , keep.lib.sizes = FALSE]

We require that there are at least 2 reads per million for at least 10 samples in order for a gene to be included in the analysis. This reduced the number of genes being considered from 5777 to 4144.

Remove low depth samples

setwd(wd)
bplot <- melt(colSums(x$counts))
colnames(bplot) <- c("Read.Counts")
bplot$Sample <- rownames(bplot)

gg <- ggplot(bplot, aes(x = factor(Sample), y = Read.Counts)) + geom_bar(stat = "identity")
gg <- gg + theme_bw() + scale_y_sqrt(breaks = c(0, 10000, 1e+06, 1e+07, 1e+08))
gg <- gg + theme(axis.text.x = element_text(size = 12, angle = 90), axis.text.y = element_text(size = 12, 
    angle = 0), axis.title = element_text(size = 14, face = "bold"))
gg <- gg + labs(x = "Sample", y = "Read Count")
gg <- gg + geom_hline(aes(yintercept = 1e+06), col = "red")

x$counts <- x$counts[, !grepl("SFD1|SFM9|SFC\\.025", colnames(x$counts))]
filt.annnotation <- fc2$annotation[fc2$annotation$GeneID %in% rownames(x$counts), 
    ]
dge <- DGEList(counts = x$counts, genes = filt.annnotation)

gg

Samples SFD1, SFM9 and SFC.025 were not sequenced to a sufficient depth to be reliable and thus are removed.

Remove drug treated samples

Samples SFU2 and SFU3 were drug treated and are removed. We repeated the analysis of the all gene DGE omitting a few patients who had anti-malarial treatments in preceding months. The patients omitted are: SFC 023, SFM007, IFM 012 and IFM 021.

x$counts <- x$counts[, !grepl("SFU2|SFU\\.3", colnames(x$counts))]
x$counts <- x$counts[, !grepl("SFC\\.023|SFM\\.7|IFM12|IFM21", colnames(x$counts))]
filt.annnotation <- fc2$annotation[fc2$annotation$GeneID %in% rownames(x$counts), 
    ]
dge <- DGEList(counts = x$counts, genes = filt.annnotation)

Now we take the log transform of our sample counts (RPKM) to estimate the proportion of different stages present.

setwd(wd)
our_log_rpkm <- rpkm(dge)
our_log_rpkm <- log2(1 + our_log_rpkm)

Estimate Contributions from Different Life-cycle Stages

Load Data

To estimate the proportion of different life-cycle stages in each of our samples we require a reference data set. Su et al provide such a reference. They performed RNA-seq at two gametocyte stages, an ookinete stage and four time points of erythrocytic stages representing ring, early trophozoite, late trophozoite, and schizont. As we do not expect any ookinete stage parasites we discarded this reference. The data was downloaded from PlasmoDB and as such read counts were reported in RPKM. To handle outlying counts in a sensible manner a log2 transformation of the RPKM values was performed. This was also done for our gene counts. By next fitting a mixture model we can estimate the proportion of different parasite stages that make up our samples.

setwd(wd)
su_rpkm <- read.csv("./data/ rpkm_7SexualAndAsexualLifeStages_suetal.csv", header = TRUE, 
    sep = ",")

# ignore the Ookinete profile as this should be absent from our data.
su_rpkm$Ookinete <- NULL
rownames(su_rpkm) <- su_rpkm$ID
su_rpkm$ID <- NULL

# take the log transform of the data which helps to manage outlier genes.
su_log_rpkm <- log2(1 + su_rpkm)

Mixture Model

Given a set of stages \(S\) and a set of genes \(g_i: i\in \{1,...,N\}\) we want to minimise

\[ \sum_{i=1}^N \left( g_{i,sample} - \sum_{s \in S} \pi_s g_{i,s} \right)^2 \]

Subject to constraints

\[ \sum_{s\in S} \pi_s = 1 \]

\[ \pi_s > 0 \]

Here \(\pi_s\) is proportion of stage \(s\) that is attributed to having contributed to our sample. This model was fit using R’s solve.QP function.

setwd(wd)
findMix <- function(Y, X) {
    X[is.na(X)] <- t(replicate(ncol(X), apply(X, 1, mean, na.rm = T)))[is.na(X)]
    Rinv <- solve(chol(t(X) %*% X))
    C <- cbind(rep(1, ncol(X)), diag(ncol(X)))
    b <- c(1, rep(0, ncol(X)))
    d <- t(Y) %*% X
    qp <- solve.QP(Dmat = Rinv, factorized = TRUE, dvec = d, Amat = C, bvec = b, 
        meq = 1)
    sol <- qp$solution
    sol[sol < 1e-10] <- 0
    return(sol)
}

Calculate Sample Life-Cycle Profiles

We fit this mixture model to each of our samples in turn. The results are then plotted. A column represents each sample in the plot below. As we are fitting proportion parameters each columns values must add to 1 over the 5 stages. Note that we have also combined the estimated proportions for the gametocyte samples into one gametocyte variable. The columns are coloured by phenotype.

setwd(wd)
# First get the intersection of the genes for the two datasets and order
# them by rowname.
inter <- intersect(rownames(our_log_rpkm), rownames(su_log_rpkm))

O <- our_log_rpkm[rownames(our_log_rpkm) %in% inter, ]
O <- O[order(rownames(O)), ]
S <- su_log_rpkm[rownames(su_log_rpkm) %in% inter, ]
S <- S[order(rownames(S)), ]

# Now lets fit some samples!
ourPlotData <- data.frame()
for (i in 1:ncol(O)) {
    mix <- findMix(O[, i], as.matrix(S))
    ourPlotData <- rbind(ourPlotData, data.frame(sample = rep(colnames(O)[i], 
        ncol(S)), stage = colnames(S), proportion = mix))
}

# Organise the results.
ourPlotData$stage <- gsub("Gametocyte.*", "Gametocyte", ourPlotData$stage)
ourPlotData <- aggregate(proportion ~ sample + stage, data = ourPlotData, FUN = sum)
ourPlotData <- within(ourPlotData, stage <- factor(stage, levels = c("Ring", 
    "Early.Trophozoite", "Late.Trophozoite", "Schizont", "Gametocyte")))
ourPlotData$phenotype <- ifelse(substring(ourPlotData$sample, 1, 1) == "I", 
    "non-severe", "severe")

# Make a pretty plot.
gg <- ggplot(ourPlotData, aes(x = factor(sample), y = proportion, fill = factor(phenotype))) + 
    geom_bar(stat = "identity")
gg <- gg + scale_fill_manual(values = c(`non-severe` = "#2c7bb6", severe = "#d7191c"))
gg <- gg + facet_wrap(~stage, ncol = 1)
gg <- gg + theme_bw()
gg <- gg + theme(axis.text.x = element_text(size = 12, angle = 90), axis.text.y = element_text(size = 12, 
    angle = 0), axis.title = element_text(size = 14, face = "bold"), strip.text.x = element_text(size = 16, 
    face = "bold"))
gg <- gg + labs(x = "Sample", y = "Proportion", fill = "Stage")
gg <- gg + theme(legend.text = element_text(size = 14))
gg <- gg + theme(legend.key.size = unit(0.25, "in"))
gg <- gg + theme(legend.title = element_text(size = 16, face = "bold"))
gg <- gg + guides(fill = guide_legend(title = "Phenotype"))
gg

Investigate Differential Expression

We now perform the Voom transformation on our count matrix. Prior to the transformation we use TMM normalisation to account for the different library sizes present in our sample. TMM was chosen as it is more robust to outliers. From the Voom variance trend it is evident that there are a number of genes that have both high variability and high expression. After looking at some of the main offenders these were identified to be influenced by staging in the parasite. Consequently it is important to account for life-cycle stage when conducting the differential expression analysis.

options(width = 150)
setwd(wd)
categories <- as.factor(substring(rownames(dge$samples), 1, 1))
dge <- calcNormFactors(dge, method = "TMM")
dge$samples$group <- categories
design <- model.matrix(~group, data = dge$samples)

v <- voom(dge, design = design, plot = TRUE)

PCA Normalising for Library Size

The PCA plot below indicates that accounting for library size alone does not cope with the impact of life-cycle stages. Notably SFC21 is clearly an outlier and was identified in the mixture model as containing later stage parasites as well as gametocytes. IFM14 is also slightly separate in the PCA plot and was identified as having a proportion of Schizont stage parasite present.

setwd(wd)
plotPCA(v$E, col = colors[categories], cex = 0.8, isLog = TRUE)

Further the Relative Log Expression (RLE) plot below suggests that there is something different about SFC21 as well as highlighting IFM060 as being different.

setwd(wd)
plotVoomRLE <- function(E, colours) {
    mn <- apply(E, 1, median)
    rle <- data.frame(sweep(E, MARGIN = 1, STATS = mn, FUN = "-"))
    boxplot(rle, col = colours, outline = FALSE, las = 2, ylim = c(-7, 7))
    abline(h = 0, col = "black")
}
plotVoomRLE(v$E, colors[categories])

PCA Normalising for Library Size, Ring, Gametocyte and Schizont effects.

To investigate the impact of life-cycle stages in our analysis we fit a linear model using limma’s removeBatchEffect. Initially ring, gametocyte and schizont parameters were fit along with the disease phenotype factor. This was because for the most part the Trophozoite stages could be represented by accounting for these stages as they would be present implicitly in the model.

The PCA indicates that we have dealt with the outlying SFC21 sample as well as other less outlying samples such as IFM14 which showed a proportion of Schizont stage parasites in the mixture model. Unfortunately due to the low number of samples that have proportions of Schizont and Gametocytes estimating differential differential expression in severe disease becomes impossible. This is because there is insufficient data to estimate these stage parameters and consequently the uncertainty in the model is too high to find significant differences between severe and non-severe disease.

setwd(wd)
covs <- data.frame(v$design[, 2])
ourPlotData$phenotype <- NULL
c <- dcast(ourPlotData, sample ~ ..., value.var = "proportion")
covs <- merge(covs, c, by.x = 0, by.y = "sample")

colnames(covs) <- c("sample", "disease", colnames(c)[2:ncol(c)])
rownames(covs) <- covs$sample
covs$sample <- NULL
covs <- covs[match(colnames(v$E), rownames(covs)), ]
stopifnot(colnames(v$E) == rownames(covs))
# head(covs)

covs <- covs[, c(1, 2, 5, 6)]
# head(covs)

mod = model.matrix(as.formula(paste("~", paste(colnames(covs), collapse = " + "), sep = "")), data = covs)

norm_counts_ring <- removeBatchEffect(v$E, covariates = mod[, 3:ncol(mod)], design = mod[, 1:2])
plotPCA(norm_counts_ring, col = colors[categories], cex = 0.8, isLog = TRUE)

The RLE plot also suggests we have dealt with SFC21 however accounting for these stages does not seem to have accounted for the differences we see in the IFM060 sample. The mixture model did not identify IFM060 as being noticeably different from the other samples and consequently it is likely that there is some other unknown factor impacting on its expression.

setwd(wd)
plotVoomRLE(norm_counts_ring, col = colors[categories])

PCA Normalising for Library Size and Ring Stage Effects

We then investigate the impact of only accounting for the Ring stage parameter in the model. This gives us more power with which to identify differential expression related to severe disease. However, from the PCA plot below it is clear that accounting for Ring stage alone is insufficient and fails to adequately deal with SFC21.

setwd(wd)
covs <- covs[, c(1, 2)]

mod = model.matrix(as.formula(paste("~", paste(colnames(covs), collapse = " + "), sep = "")), data = covs)

norm_counts_ring <- removeBatchEffect(v$E, covariates = mod[, 3:ncol(mod)], design = mod[, 1:2])
plotPCA(norm_counts_ring, col = colors[categories], cex = 0.8, isLog = TRUE)

We are however able to identify differentially expressed genes in this less parameterised model. The summary of results accounting only for the Ring stage variable are given below. This test was performed using the limma-Voom pipeline. Ideally we would be able to keep both the power in out tests and account for the remaining unwanted factors. To achieve this we make use of RUV-4 to estimate dummy variables that represent multiple unknown factors of unwanted variation.

setwd(wd)
stopifnot(colnames(dge) == rownames(mod))
v2 <- voom(dge, design = mod, plot = FALSE)
fit <- lmFit(v2, mod)
fit <- eBayes(fit, robust = TRUE)

summary(de1 <- decideTests(fit, adjust.method = "BH", p.value = 0.05))

##    (Intercept) disease Ring
## -1          81      18 1265
## 0          681    4069 1734
## 1         3382      57 1145

Estimate Unwanted Factors of Variation

To cope with the outlier samples such as SFC21 whilst retaining statistical power we estimate factors of unwanted variation using RUV-4.
RUV-4 requires a set of control genes which are believed to be relatively unaffected by the condition of interest, in our case this is disease severity. RUV-4 is however fairly robust to the choice of control genes.
We chose to use the 1000 genes found to have the highest p-values in the experiment of Vignali et al as controls. The experiment of Vignali et al looked at differences in expression between pregnancy associated malaria and childhood malaria. Although this is not the same association we are investigating it was considered close enough to perform adequately as a source of control genes. Further an analysis using SVA which does not require controls and rather estimates them empirically was found to produce similar results with only 5 out of 119 genes found using SVA missing from the RUV-4 approach. Further RUV-4 attempts to recover some variation that may be lost in the vanilla SVA approach when the factor of interest (severe disease) correlates with an unwanted factor. Consequently it leads to a higher number of differentially expressed genes being found. It was also thought that having an independently sourced set of control genes was preferable to empirically deriving such a set.

setwd(wd)
contol_genes_vignali <- read.table("./data/contol_genes_vignali.txt", quote = "\"")

ctrl_vignali <- geneID_mappings$current[geneID_mappings$old %in% contol_genes_vignali$V1]
length(ctrl_vignali)

## [1] 1009

empirical_controls <- ctrl_vignali[0:length(ctrl_vignali)]
empirical_controls <- rownames(v$E) %in% empirical_controls

categoriesRUV <- categories
categoriesRUV <- data.matrix(as.numeric(categoriesRUV == "S"))
ring <- data.matrix(mod[, c(1, 3)])
genes <- data.matrix(t(v$E))

ruv <- RUV4(genes, categoriesRUV, empirical_controls, 3, Z = ring)

modRUV = cbind(mod, ruv$W)

norm_counts_ring_ruv <- removeBatchEffect(v$E, covariates = modRUV[, 3:ncol(modRUV)], design = modRUV[, 1:2])

Note that although we used 1000 genes from the experiment of Vignali et al only 533 were found in our reduced expression matrix.

The PCA plot below indicates that we have dealt with most of the problems due to staging. Here we have included the Ring stage proportion from the mixture model as well as three factors of unwanted variation estimated using RUV-4.

setwd(wd)
plotPCA(norm_counts_ring_ruv, col = colors[categories], cex = 0.8, isLog = TRUE)

The RLE plot also indicates that we have succesfully dealt with most of the staging issues. Both SFC21 and IFM14 have reasonable box plots. Moreover, IFM060 has a nicer boxplot indicating that in using RUV-4, not only have we dealt with staging issues, we have also accounted for some other unknown confounding factors that would have impacted our results. The variation in each sample has also been reduced which is indicated in the reduced height of the boxplot whiskers. Finally, the results were found to be relatively robust to the removal of the outlier samples such as SFC21 and IFM14. Consequently, this approach seems to succesfully deal with both life-cycle staging issues and other unknown impacting factors.

setwd(wd)
plotVoomRLE(norm_counts_ring_ruv, colors[categories])

Identify DE Genes using Limma and Voom

We now use the limma-voom pipeline, with the robust ebayes option which handles dispersion outliers. This was done to further ensure our results were less likely to be affected by outlier samples. Multiple testing correction was performed using the Benjamini-Hochberg approach.

setwd(wd)
stopifnot(colnames(dge) == rownames(modRUV))
v2 <- voom(dge, design = modRUV, plot = F)
fit <- lmFit(v2, modRUV)
fit <- eBayes(fit, robust = TRUE)
s <- summary(de2 <- decideTests(fit, adjust.method = "BH", p.value = 0.05))
s

##    (Intercept) disease Ring               
## -1          91      72 1393 1621 1101  478
## 0          548    4033 1450 1651 2070 3114
## 1         3505      39 1301  872  973  552

Overall 111 genes were found to be differentially expressed between severe and non-severe cases of malaria with a false dicovery rate threshold of 0.05.

A good check for validity of our model it to look at the distribution of the resulting p-values. If everything is okay we would expect a uniform distribution except near \(p=0\) where we would hope to see a spike. The barplot below indicates this is what we see which is helpful in affirming that we have done okay in removing unwanted variation without negatively impacting on the variation due to the variable of interest (diseas severity).

setwd(wd)
top_ring_ruv <- topTable(fit, coef = 2, p.value = 0.1, sort.by = "p", number = Inf, adjust.method = "BH", confint = TRUE)
hist <- data.frame(topTable(fit, coef = 2, number = Inf))
gg <- ggplot(hist, aes(x = P.Value)) + geom_histogram(binwidth = 0.01)
gg <- gg + theme_bw()
gg <- gg + theme(axis.text.x = element_text(size = 12), axis.text.y = element_text(size = 12, angle = 0), axis.title = element_text(size = 12, face = "bold"))
gg <- gg + labs(x = "P value", y = "Count")
gg

Results table

Below is a table of genes that were found to be differentially expressed, ordered by their respective p-values. The 95% confidence intervals are given with the estimated LFC as well as the BH adjusted p-values and the log-odds that the gene is differentially expressed. Here we report for interest sake all genes up to a adjusted p-value threshold of 0.1.

setwd(wd)
# Load additional gene information
GeneAnnotationPlasmoDB <- fread("./data/GeneAnnotationPlasmoDB.txt", data.table = FALSE, na.strings = "N/A")

# First lets import some additional gene information to make a nicer table
GeneAnnotationPlasmoDB <- GeneAnnotationPlasmoDB[, colnames(GeneAnnotationPlasmoDB) %in% c("[Gene ID]", "[Product Description]", "[Gene Name or Symbol]")]
top_ring_ruv <- merge(top_ring_ruv, GeneAnnotationPlasmoDB, by.x = 0, by.y = "[Gene ID]", all.x = TRUE)
top_ring_ruv <- top_ring_ruv[with(top_ring_ruv, order(adj.P.Val)), ]

# Now print the table
top_ring_ruv$P.Value <- format(top_ring_ruv$P.Value, scientific = TRUE, digits = 3)
top_ring_ruv$adj.P.Val <- format(top_ring_ruv$adj.P.Val, scientific = TRUE, digits = 3)
kable(top_ring_ruv[, c(2:4, 6:ncol(top_ring_ruv))], digits = 3)

	GeneID	Chr	Start	Strand	Length	logFC	CI.L	CI.R	AveExpr	t	P.Value	adj.P.Val	B	[Product Description]	[Gene Name or Symbol]
9	PF3D7_0115700	Pf3D7_01_v3	607390	-	7504	-1.695	-2.671	-0.718	4.472	-5.551	2.64e-06	5.48e-03	4.608	erythrocyte membrane protein 1, PfEMP1	VAR
14	PF3D7_0202000	Pf3D7_02_v3	103385	-	2412	-2.232	-3.132	-1.331	14.042	-5.745	2.34e-06	5.48e-03	4.793	knob-associated histidine-rich protein	KAHRP
271	PF3D7_1255200	Pf3D7_12_v3	2241271	-	7692	-1.490	-2.030	-0.951	4.566	-5.412	4.07e-06	5.63e-03	4.220	erythrocyte membrane protein 1, PfEMP1	VAR
23	PF3D7_0223500	Pf3D7_02_v3	916352	-	7297	-1.139	-1.932	-0.345	5.205	-4.963	1.63e-05	8.42e-03	2.968	erythrocyte membrane protein 1, PfEMP1	VAR
31	PF3D7_0316600	Pf3D7_03_v3	669302	-	1572	-1.407	-1.944	-0.870	10.248	-5.170	9.43e-06	8.42e-03	3.434	formate-nitrite transporter	FNT
37	PF3D7_0400100	Pf3D7_04_v3	28706	+	8972	-1.593	-1.921	-1.266	4.810	-5.026	1.34e-05	8.42e-03	3.139	erythrocyte membrane protein 1, PfEMP1	VAR
156	PF3D7_0900100	Pf3D7_09_v3	20080	+	7806	-1.462	-2.010	-0.915	4.673	-5.057	1.22e-05	8.42e-03	3.224	erythrocyte membrane protein 1, PfEMP1	VAR
189	PF3D7_1023600	Pf3D7_10_v3	987358	-	2791	-2.045	-3.030	-1.060	-0.122	-4.980	1.54e-05	8.42e-03	2.487	conserved Plasmodium protein, unknown function	NA
243	PF3D7_1223900	Pf3D7_12_v3	972710	-	684	-2.228	-4.701	0.246	2.658	-4.936	1.86e-05	8.58e-03	2.764	50S ribosomal protein L24, putative	NA
142	PF3D7_0809100	Pf3D7_08_v3	459312	+	7256	-1.773	-3.635	0.089	3.226	-4.884	2.08e-05	8.60e-03	2.665	erythrocyte membrane protein 1, PfEMP1	VAR
4	PF3D7_0106000	Pf3D7_01_v3	255775	-	2769	1.185	0.199	2.172	1.476	4.664	4.07e-05	1.23e-02	1.920	conserved Plasmodium protein, unknown function	NA
36	PF3D7_0324900	Pf3D7_03_v3	1030822	-	7433	-1.274	-2.295	-0.254	3.988	-4.507	6.54e-05	1.23e-02	1.680	erythrocyte membrane protein 1, PfEMP1	VAR
40	PF3D7_0404600	Pf3D7_04_v3	247731	+	12417	-1.457	-1.770	-1.145	7.604	-4.502	7.43e-05	1.23e-02	1.515	conserved Plasmodium membrane protein, unknown function	NA
45	PF3D7_0412700	Pf3D7_04_v3	561667	-	7676	-1.440	-2.188	-0.692	4.841	-4.530	6.09e-05	1.23e-02	1.753	erythrocyte membrane protein 1, PfEMP1	VAR
85	PF3D7_0600600	Pf3D7_06_v3	29618	-	1867	-1.681	-2.462	-0.901	3.049	-4.700	3.63e-05	1.23e-02	2.155	erythrocyte membrane protein 1 (PfEMP1), exon 2	VAR
105	PF3D7_0632800	Pf3D7_06_v3	1374797	-	7831	-1.240	-1.577	-0.904	4.681	-4.544	5.85e-05	1.23e-02	1.791	erythrocyte membrane protein 1, PfEMP1	VAR
107	PF3D7_0703100	Pf3D7_07_v3	121414	+	543	0.985	0.194	1.777	3.582	4.477	7.15e-05	1.23e-02	1.588	conserved Plasmodium protein, unknown function	NA
120	PF3D7_0712600	Pf3D7_07_v3	566726	-	7583	-1.748	-2.417	-1.079	3.429	-4.685	3.80e-05	1.23e-02	2.144	erythrocyte membrane protein 1, PfEMP1	VAR
133	PF3D7_0800100	Pf3D7_08_v3	21361	+	7293	-1.596	-2.257	-0.936	4.508	-4.513	6.58e-05	1.23e-02	1.687	erythrocyte membrane protein 1, PfEMP1	VAR
136	PF3D7_0802000	Pf3D7_08_v3	146089	+	4194	-1.266	-1.753	-0.778	9.188	-4.509	6.90e-05	1.23e-02	1.558	glutamate dehydrogenase, putative	GDH3
175	PF3D7_1000100	Pf3D7_10_v3	28490	+	7675	-1.339	-1.639	-1.040	4.505	-4.569	5.41e-05	1.23e-02	1.861	erythrocyte membrane protein 1, PfEMP1	VAR
204	PF3D7_1105100	Pf3D7_11_v3	226065	+	354	-1.063	-1.589	-0.536	9.705	-4.600	5.10e-05	1.23e-02	1.799	histone H2B	H2B
216	PF3D7_1123100	Pf3D7_11_v3	909366	+	6959	-0.597	-0.908	-0.287	9.103	-4.524	6.21e-05	1.23e-02	1.610	calcium-dependent protein kinase 7	CDPK7
231	PF3D7_1200100	Pf3D7_12_v3	16973	+	7525	-1.592	-2.227	-0.957	4.052	-4.609	4.80e-05	1.23e-02	1.964	erythrocyte membrane protein 1, PfEMP1	VAR
296	PF3D7_1344800	Pf3D7_13_v3	1796274	+	1436	-0.768	-1.123	-0.413	6.260	-4.560	5.58e-05	1.23e-02	1.803	aspartate carbamoyltransferase	ATCase
248	PF3D7_1228800	Pf3D7_12_v3	1169557	-	9630	-0.657	-1.727	0.414	6.788	-4.415	8.63e-05	1.38e-02	1.365	WD repeat-containing protein, putative	NA
84	PF3D7_0532400	Pf3D7_05_v3	1312471	+	1684	-1.315	-1.774	-0.856	8.118	-4.393	9.77e-05	1.40e-02	1.251	lysine-rich membrane-associated PHISTb protein	LyMP
102	PF3D7_0626200	Pf3D7_06_v3	1058666	-	1257	1.643	0.966	2.319	2.878	4.387	9.37e-05	1.40e-02	1.321	conserved Plasmodium protein, unknown function	NA
244	PF3D7_1224000	Pf3D7_12_v3	974372	+	1170	-1.670	-3.718	0.378	2.666	-4.378	9.63e-05	1.40e-02	1.298	GTP cyclohydrolase I	GCH1
322	PF3D7_1414200	Pf3D7_14_v3	564024	-	1224	0.818	0.286	1.349	5.924	4.353	1.04e-04	1.43e-02	1.233	conserved Plasmodium protein, unknown function	NA
198	PF3D7_1100100	Pf3D7_11_v3	24160	+	7439	-1.288	-1.828	-0.748	4.713	-4.310	1.18e-04	1.58e-02	1.148	erythrocyte membrane protein 1, PfEMP1	VAR
6	PF3D7_0109700	Pf3D7_01_v3	379149	-	658	-1.423	-2.847	0.001	4.127	-4.269	1.33e-04	1.73e-02	1.040	rRNA biogenesis protein RRP36, putative	RRP36
71	PF3D7_0519500	Pf3D7_05_v3	801450	-	7678	-0.942	-1.573	-0.311	7.017	-4.157	1.86e-04	2.09e-02	0.640	carbon catabolite repressor protein 4, putative	CCR4
153	PF3D7_0830300	Pf3D7_08_v3	1290240	-	1167	1.591	1.299	1.884	2.023	4.162	1.83e-04	2.09e-02	0.694	sporozoite invasion-associated protein 2	SIAP2
168	PF3D7_0925300	Pf3D7_09_v3	1019164	-	1740	2.109	1.367	2.850	0.173	4.158	1.86e-04	2.09e-02	0.535	proline–tRNA ligase, putative	aPRS
193	PF3D7_1028000	Pf3D7_10_v3	1160031	+	3391	-0.991	-1.656	-0.326	6.363	-4.158	1.86e-04	2.09e-02	0.667	methyltransferase, putative	NA
285	PF3D7_1316600	Pf3D7_13_v3	691014	+	3112	-1.262	-1.567	-0.958	6.456	-4.192	1.76e-04	2.09e-02	0.726	choline-phosphate cytidylyltransferase	CCT
117	PF3D7_0711700	Pf3D7_07_v3	511950	-	7476	-1.151	-1.908	-0.394	4.402	-4.081	2.34e-04	2.50e-02	0.533	erythrocyte membrane protein 1, PfEMP1	VAR
287	PF3D7_1318300	Pf3D7_13_v3	753910	+	5523	-1.051	-1.390	-0.712	5.766	-4.078	2.36e-04	2.50e-02	0.476	conserved Plasmodium protein, unknown function	NA
166	PF3D7_0917800	Pf3D7_09_v3	734629	+	1314	1.808	1.549	2.068	1.383	4.051	2.55e-04	2.64e-02	0.378	conserved Plasmodium protein, unknown function	NA
58	PF3D7_0500100	Pf3D7_05_v3	20929	+	7528	-1.287	-1.826	-0.748	3.399	-4.023	2.77e-04	2.68e-02	0.384	erythrocyte membrane protein 1, PfEMP1	VAR
224	PF3D7_1135300	Pf3D7_11_v3	1381015	-	1230	1.219	0.684	1.754	2.281	4.032	2.70e-04	2.68e-02	0.380	conserved Plasmodium membrane protein, unknown function	NA
238	PF3D7_1213100	Pf3D7_12_v3	576417	-	164	-2.305	-2.853	-1.757	2.312	-4.036	2.79e-04	2.68e-02	0.339	U1 spliceosomal RNA	NA
286	PF3D7_1316900	Pf3D7_13_v3	701047	-	2877	0.669	0.039	1.299	7.752	4.007	2.90e-04	2.73e-02	0.185	conserved Plasmodium protein, unknown function	NA
242	PF3D7_1223400	Pf3D7_12_v3	941125	+	5621	-0.766	-2.537	1.005	11.206	-3.995	3.01e-04	2.77e-02	0.101	phospholipid-transporting ATPase, putative	NA
124	PF3D7_0713600	Pf3D7_07_v3	617933	+	2935	1.165	0.776	1.554	3.264	3.969	3.24e-04	2.92e-02	0.245	mitochondrial ribosomal protein S5 precursor, putative	NA
41	PF3D7_0404900	Pf3D7_04_v3	267244	-	1137	1.903	1.310	2.495	3.340	3.976	3.31e-04	2.92e-02	0.231	6-cysteine protein	P41
65	PF3D7_0509000	Pf3D7_05_v3	376855	-	1598	-0.641	-1.129	-0.152	5.782	-3.938	3.55e-04	2.94e-02	0.094	SNAP protein (soluble N-ethylmaleimide-sensitive factor attachment protein), putative	NA
143	PF3D7_0810800	Pf3D7_08_v3	548200	+	2417	-1.107	-1.926	-0.288	7.387	-3.954	3.49e-04	2.94e-02	0.064	hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase	PPPK-DHPS
275	PF3D7_1303000	Pf3D7_13_v3	158144	+	635	-1.133	-2.435	0.170	3.355	-3.939	3.54e-04	2.94e-02	0.170	conserved Plasmodium protein, unknown function	NA
139	PF3D7_0805600	Pf3D7_08_v3	312034	+	927	0.774	0.335	1.213	7.188	3.895	4.02e-04	3.22e-02	-0.097	PAP2-like protein, putative	NA
315	PF3D7_1400100	Pf3D7_14_v3	1393	+	3951	-1.321	-1.729	-0.913	4.966	-3.901	4.04e-04	3.22e-02	0.021	erythrocyte membrane protein 1 (PfEMP1), pseudogene	NA
251	PF3D7_1230500	Pf3D7_12_v3	1253973	-	1509	0.909	-0.278	2.097	4.436	3.879	4.22e-04	3.30e-02	-0.002	WD repeat-containing protein, putative	NA
24	PF3D7_0300100	Pf3D7_03_v3	36965	+	7518	-1.134	-1.505	-0.762	4.351	-3.865	4.39e-04	3.32e-02	-0.035	erythrocyte membrane protein 1, PfEMP1	VAR
265	PF3D7_1246600	Pf3D7_12_v3	1936522	+	1173	-0.852	-1.815	0.111	5.347	-3.864	4.40e-04	3.32e-02	-0.078	pre-mRNA-splicing factor CWC26, putative	BUD13
7	PF3D7_0113000	Pf3D7_01_v3	487892	-	2236	-1.480	-3.080	0.121	11.345	-3.858	5.27e-04	3.64e-02	-0.387	glutamic acid-rich protein	GARP
237	PF3D7_1212800	Pf3D7_12_v3	565966	+	966	1.021	0.421	1.621	2.457	3.805	5.22e-04	3.64e-02	-0.185	iron-sulfur subunit of succinate dehydrogenase	NA
260	PF3D7_1240900	Pf3D7_12_v3	1735543	+	7866	-1.406	-2.440	-0.371	4.296	-3.816	5.12e-04	3.64e-02	-0.165	erythrocyte membrane protein 1, PfEMP1	VAR
267	PF3D7_1249000	Pf3D7_12_v3	2005175	-	2019	1.002	0.352	1.652	1.154	3.821	4.98e-04	3.64e-02	-0.189	conserved Plasmodium membrane protein, unknown function	NA
347	PF3D7_1457000	Pf3D7_14_v3	2336649	-	2505	-0.648	-1.396	0.101	8.961	-3.813	5.11e-04	3.64e-02	-0.374	signal peptide peptidase	SPP
83	PF3D7_0532300	Pf3D7_05_v3	1308278	+	1663	-1.199	-1.939	-0.459	10.800	-3.818	5.46e-04	3.65e-02	-0.417	Plasmodium exported protein (PHISTb), unknown function	NA
316	PF3D7_1401400	Pf3D7_14_v3	53411	-	324	-0.853	-1.218	-0.488	12.466	-3.797	5.42e-04	3.65e-02	-0.445	early transcribed membrane protein 14.1	ETRAMP14
111	PF3D7_0704600	Pf3D7_07_v3	216024	-	13049	-0.663	-1.466	0.140	10.228	-3.766	5.84e-04	3.78e-02	-0.524	E3 ubiquitin-protein ligase	UT
205	PF3D7_1105300	Pf3D7_11_v3	231847	-	2392	1.352	1.003	1.700	1.696	3.767	5.82e-04	3.78e-02	-0.299	conserved Plasmodium protein, unknown function	NA
211	PF3D7_1118400	Pf3D7_11_v3	699869	-	921	1.065	0.445	1.685	3.280	3.756	6.02e-04	3.84e-02	-0.298	haloacid dehalogenase-like hydrolase, putative	NA
262	PF3D7_1244200	Pf3D7_12_v3	1852844	-	2838	1.031	0.729	1.333	5.481	3.739	6.32e-04	3.97e-02	-0.420	RNA polymerase II transcription factor B subunit 2, putative	TFB2
54	PF3D7_0419800	Pf3D7_04_v3	874811	-	711	0.644	0.109	1.179	5.924	3.733	6.43e-04	3.98e-02	-0.460	60S ribosomal protein L7ae/L30e, putative	NA
13	PF3D7_0201900	Pf3D7_02_v3	91318	-	7521	-1.527	-2.211	-0.843	10.614	-3.763	6.87e-04	4.12e-02	-0.612	erythrocyte membrane protein 3	EMP3
146	PF3D7_0821500	Pf3D7_08_v3	967901	-	840	0.820	0.569	1.070	4.918	3.706	6.94e-04	4.12e-02	-0.471	ribosomal RNA small subunit methyltransferase NEP1, putative	NEP1
147	PF3D7_0822200	Pf3D7_08_v3	982570	+	5127	1.108	0.550	1.666	2.942	3.700	7.07e-04	4.12e-02	-0.438	conserved Plasmodium membrane protein, unknown function	NA
149	PF3D7_0823800	Pf3D7_08_v3	1043813	+	1968	-0.753	-1.486	-0.020	5.245	-3.700	7.05e-04	4.12e-02	-0.518	DnaJ protein, putative	NA
51	PF3D7_0417400	Pf3D7_04_v3	756294	+	20310	-0.792	-1.152	-0.432	8.067	-3.685	7.37e-04	4.24e-02	-0.703	conserved Plasmodium protein, unknown function	NA
121	PF3D7_0712800	Pf3D7_07_v3	581386	-	7538	-1.348	-2.079	-0.616	4.007	-3.677	7.57e-04	4.24e-02	-0.508	erythrocyte membrane protein 1, PfEMP1	VAR
154	PF3D7_0831700	Pf3D7_08_v3	1365467	-	2040	-0.982	-1.261	-0.702	13.434	-3.690	7.53e-04	4.24e-02	-0.742	heat shock protein 70	HSP70-x
1	mal_rna_11:rRNA	M76611	1916	-	108	-1.640	-2.203	-1.077	1.870	-3.641	8.35e-04	4.27e-02	-0.606	NA	NA
25	PF3D7_0302800	Pf3D7_03_v3	148046	-	1260	1.163	0.554	1.772	5.270	3.630	8.76e-04	4.27e-02	-0.700	conserved Plasmodium protein, unknown function	NA
47	PF3D7_0413900	Pf3D7_04_v3	623168	-	3059	-0.742	-1.627	0.143	6.964	-3.656	8.01e-04	4.27e-02	-0.736	ubiquitin carboxyl-terminal hydrolase 13, putative	USP13
57	PF3D7_0423800	Pf3D7_04_v3	1076347	+	1188	2.290	1.835	2.746	2.134	3.628	9.24e-04	4.27e-02	-0.670	cysteine-rich protective antigen	CyRPA
68	PF3D7_0512000	Pf3D7_05_v3	527639	+	1028	-1.030	-1.691	-0.369	5.218	-3.609	9.15e-04	4.27e-02	-0.741	prefoldin subunit 6, putative	NA
81	PF3D7_0529000	Pf3D7_05_v3	1186787	-	2160	0.470	-0.311	1.252	7.651	3.631	8.60e-04	4.27e-02	-0.831	conserved Plasmodium protein, unknown function	NA
103	PF3D7_0629600	Pf3D7_06_v3	1218307	+	945	0.546	0.103	0.988	4.979	3.605	9.25e-04	4.27e-02	-0.734	conserved Plasmodium protein, unknown function	NA
116	PF3D7_0711200	Pf3D7_07_v3	495238	+	3003	1.222	0.659	1.785	2.256	3.636	8.47e-04	4.27e-02	-0.603	conserved Plasmodium protein, unknown function	NA
132	PF3D7_0733000	Pf3D7_07_v3	1417588	-	8647	-1.043	-1.615	-0.471	4.926	-3.623	8.79e-04	4.27e-02	-0.686	erythrocyte membrane protein 1, PfEMP1	VAR
161	PF3D7_0909600	Pf3D7_09_v3	433238	-	2136	1.511	1.178	1.843	0.836	3.642	8.34e-04	4.27e-02	-0.635	conserved Plasmodium protein, unknown function	NA
197	PF3D7_1041300	Pf3D7_10_v3	1642401	-	7548	-1.101	-1.727	-0.474	4.981	-3.628	8.68e-04	4.27e-02	-0.674	erythrocyte membrane protein 1, PfEMP1	VAR
213	PF3D7_1121100	Pf3D7_11_v3	794254	-	5308	-0.793	-1.429	-0.157	8.461	-3.604	9.27e-04	4.27e-02	-0.914	conserved Plasmodium protein, unknown function	NA
298	PF3D7_1346200	Pf3D7_13_v3	1845878	-	507	2.002	1.693	2.312	0.978	3.614	9.19e-04	4.27e-02	-0.701	nuclear import protein MOG1, putative	NA
326	PF3D7_1421150	Pf3D7_14_v3	875173	-	149	-1.649	-2.239	-1.059	1.022	-3.645	8.26e-04	4.27e-02	-0.626	C/D small nucleolar RNA	NA
337	PF3D7_1444800	Pf3D7_14_v3	1844041	-	1577	-0.692	-1.263	-0.122	10.290	-3.622	8.81e-04	4.27e-02	-0.901	fructose-bisphosphate aldolase	FBPA
346	PF3D7_1451800	Pf3D7_14_v3	2123461	+	3139	-0.690	-1.189	-0.190	4.615	-3.616	8.96e-04	4.27e-02	-0.702	sortilin	NA
207	PF3D7_1108700	Pf3D7_11_v3	373238	-	1623	0.745	0.222	1.267	6.854	3.584	9.81e-04	4.47e-02	-0.904	heat shock protein DnaJ homologue Pfj2	NA
95	PF3D7_0617200	Pf3D7_06_v3	717050	+	1868	-1.064	-2.315	0.188	7.853	-3.587	1.03e-03	4.57e-02	-0.992	conserved Plasmodium protein, unknown function	NA
299	PF3D7_1346400	Pf3D7_13_v3	1852898	+	17967	-0.706	-0.963	-0.449	7.849	-3.569	1.02e-03	4.57e-02	-1.005	conserved Plasmodium protein, unknown function	NA
259	PF3D7_1240600	Pf3D7_12_v3	1719574	+	7883	-1.224	-1.818	-0.629	3.851	-3.554	1.07e-03	4.66e-02	-0.814	erythrocyte membrane protein 1, PfEMP1	VAR
303	PF3D7_1354300	Pf3D7_13_v3	2164239	-	3178	-0.517	-1.135	0.102	9.432	-3.556	1.06e-03	4.66e-02	-1.078	large subunit rRNA methyltransferase, putative	NA
220	PF3D7_1126300	Pf3D7_11_v3	1026976	+	2569	1.067	0.818	1.316	4.596	3.543	1.10e-03	4.76e-02	-0.877	DnaJ protein, putative	NA
62	PF3D7_0503100	Pf3D7_05_v3	127064	-	1614	-1.336	-1.742	-0.929	2.177	-3.504	1.23e-03	4.80e-02	-0.920	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative	IspE
99	PF3D7_0622700	Pf3D7_06_v3	916000	-	1300	1.532	0.053	3.011	1.425	3.534	1.13e-03	4.80e-02	-0.858	conserved Plasmodium membrane protein, unknown function	NA
128	PF3D7_0719500	Pf3D7_07_v3	854652	-	2003	0.995	0.204	1.786	1.461	3.509	1.21e-03	4.80e-02	-0.921	LEM3/CDC50 family protein, putative	NA
170	PF3D7_0928500	Pf3D7_09_v3	1146239	-	959	-1.164	-2.209	-0.119	2.608	-3.509	1.21e-03	4.80e-02	-0.908	conserved Plasmodium protein, unknown function	NA
177	PF3D7_1003900	Pf3D7_10_v3	177921	+	950	1.677	0.884	2.470	0.332	3.524	1.16e-03	4.80e-02	-0.924	conserved Plasmodium protein, unknown function	NA
180	PF3D7_1012000	Pf3D7_10_v3	463493	+	3514	-0.679	-1.272	-0.085	6.052	-3.496	1.26e-03	4.80e-02	-1.090	E3 ubiquitin-protein ligase, putative	NA
202	PF3D7_1102800	Pf3D7_11_v3	131703	-	285	-0.910	-1.825	0.006	13.470	-3.540	1.15e-03	4.80e-02	-1.138	early transcribed membrane protein 11.2	ETRAMP11.2
288	PF3D7_1321600	Pf3D7_13_v3	897716	+	3329	1.398	0.495	2.301	0.132	3.515	1.19e-03	4.80e-02	-0.956	phosphodiesterase gamma, putative	PDEgamma
310	PF3D7_1365600	Pf3D7_13_v3	2621261	+	2740	0.733	-0.151	1.617	4.139	3.495	1.26e-03	4.80e-02	-0.967	DNA topoisomerase VI, b subunit, putative	NA
331	PF3D7_1428100	Pf3D7_14_v3	1098038	-	1914	0.966	0.460	1.473	3.882	3.497	1.26e-03	4.80e-02	-0.959	WW domain-binding protein 11, putative	NA
341	PF3D7_1446900	Pf3D7_14_v3	1924425	-	2226	0.763	0.448	1.079	6.864	3.500	1.24e-03	4.80e-02	-1.127	glutaminyl-peptide cyclotransferase, putative	NA
349	PF3D7_1457900	Pf3D7_14_v3	2375579	+	10368	-0.756	-1.417	-0.094	5.650	-3.528	1.15e-03	4.80e-02	-0.978	conserved Plasmodium protein, unknown function	NA
356	PF3D7_1470200	Pf3D7_14_v3	2877586	-	1163	-0.675	-1.356	0.006	5.398	-3.515	1.19e-03	4.80e-02	-0.983	conserved Plasmodium protein, unknown function	NA
138	PF3D7_0804900	Pf3D7_08_v3	279711	-	1476	0.919	-0.323	2.160	5.949	3.480	1.32e-03	4.96e-02	-1.116	GTPase-activating protein, putative	NA
338	PF3D7_1445600	Pf3D7_14_v3	1871778	+	2604	0.679	0.247	1.112	8.272	3.476	1.33e-03	4.97e-02	-1.260	RNA-binding protein, putative	NA
127	PF3D7_0717600	Pf3D7_07_v3	758720	-	4158	-1.473	-1.889	-1.056	3.059	-3.474	1.36e-03	5.02e-02	-1.008	conserved Plasmodium protein, unknown function	NA
73	PF3D7_0522300	Pf3D7_05_v3	902613	-	2232	-0.572	-1.174	0.030	6.700	-3.459	1.39e-03	5.09e-02	-1.227	S-adenosylmethionine-dependent methyltransferase, putative	NA
343	PF3D7_1449900	Pf3D7_14_v3	2044007	-	1023	1.308	0.758	1.858	2.638	3.457	1.40e-03	5.09e-02	-1.031	conserved Plasmodium protein, unknown function	NA
148	PF3D7_0823200	Pf3D7_08_v3	1022629	-	1218	-0.619	-0.974	-0.264	9.617	-3.453	1.42e-03	5.12e-02	-1.351	RNA-binding protein, putative	NA
335	PF3D7_1437800	Pf3D7_14_v3	1530276	-	555	1.770	1.086	2.453	2.830	3.457	1.44e-03	5.16e-02	-1.054	trafficking protein particle complex subunit 5, putative	TRAPPC5
28	PF3D7_0305000	Pf3D7_03_v3	234058	-	1277	0.947	0.074	1.820	3.438	3.441	1.47e-03	5.16e-02	-1.086	elongation factor Ts	EF-Ts
209	PF3D7_1111300	Pf3D7_11_v3	442959	-	870	0.841	0.548	1.135	2.945	3.438	1.48e-03	5.16e-02	-1.079	SNARE protein, putative	GS27
305	PF3D7_1355700	Pf3D7_13_v3	2206592	-	3867	1.237	0.365	2.109	7.278	3.465	1.48e-03	5.16e-02	-1.296	NLI interacting factor-like phosphatase, putative	NIF3
19	PF3D7_0216000	Pf3D7_02_v3	658636	+	5994	-2.074	-2.621	-1.528	0.535	-3.431	1.53e-03	5.29e-02	-1.141	DEAD/DEAH box helicase, putative	NA
53	PF3D7_0419500	Pf3D7_04_v3	866501	-	1611	1.223	0.163	2.283	3.890	3.421	1.55e-03	5.30e-02	-1.144	conserved Plasmodium membrane protein, unknown function	NA
114	PF3D7_0708500	Pf3D7_07_v3	385583	-	2739	-0.737	-1.370	-0.105	6.652	-3.415	1.58e-03	5.35e-02	-1.337	heat shock protein 86 family protein	NA
69	PF3D7_0513600	Pf3D7_05_v3	574941	-	3565	-1.045	-1.363	-0.726	5.614	-3.413	1.61e-03	5.39e-02	-1.283	deoxyribodipyrimidine photo-lyase, putative	NA
210	PF3D7_1115200	Pf3D7_11_v3	576773	+	3504	-0.659	-1.554	0.236	8.247	-3.404	1.63e-03	5.39e-02	-1.445	histone-lysine N-methyltransferase SET7	SET7
229	PF3D7_1145500	Pf3D7_11_v3	1807359	+	2772	1.102	0.252	1.951	1.564	3.404	1.63e-03	5.39e-02	-1.163	ABC transporter B family member 3, putative	ABCB3
59	PF3D7_0501300	Pf3D7_05_v3	68930	+	1184	-0.925	-1.601	-0.250	12.486	-3.399	1.71e-03	5.59e-02	-1.517	skeleton-binding protein 1	SBP1
246	PF3D7_1225600	Pf3D7_12_v3	1035261	-	2895	-0.478	-2.453	1.498	8.007	-3.386	1.71e-03	5.59e-02	-1.485	conserved Plasmodium protein, unknown function	NA
324	PF3D7_1417600	Pf3D7_14_v3	730694	-	13989	-0.568	-1.358	0.222	8.915	-3.382	1.73e-03	5.59e-02	-1.523	conserved Plasmodium protein, unknown function	NA
297	PF3D7_1345200	Pf3D7_13_v3	1812220	-	1710	1.084	0.716	1.452	3.402	3.379	1.74e-03	5.59e-02	-1.227	rhomboid protease ROM6, putative	ROM6
29	PF3D7_0310800	Pf3D7_03_v3	464662	+	330	0.487	-0.214	1.187	6.132	3.360	1.84e-03	5.68e-02	-1.439	conserved Plasmodium protein, unknown function	NA
122	PF3D7_0712900	Pf3D7_07_v3	590326	-	7408	-1.100	-1.332	-0.869	4.206	-3.367	1.80e-03	5.68e-02	-1.294	erythrocyte membrane protein 1, PfEMP1	VAR
190	PF3D7_1025000	Pf3D7_10_v3	1045608	-	4153	-0.570	-0.985	-0.156	8.252	-3.366	1.80e-03	5.68e-02	-1.534	formin 2, putative	NA
212	PF3D7_1119200	Pf3D7_11_v3	722717	-	573	-1.038	-1.443	-0.632	3.783	-3.361	1.83e-03	5.68e-02	-1.279	conserved protein, unknown function	NA
218	PF3D7_1124800	Pf3D7_11_v3	976880	-	1057	-0.568	-1.158	0.023	6.670	-3.363	1.82e-03	5.68e-02	-1.469	nuclear preribosomal assembly protein, putative	NA
234	PF3D7_1206300	Pf3D7_12_v3	281020	-	8283	-1.407	-1.752	-1.062	1.456	-3.354	1.87e-03	5.73e-02	-1.280	conserved Plasmodium protein, unknown function	NA
50	PF3D7_0416100	Pf3D7_04_v3	706529	+	2481	-0.909	-1.422	-0.396	4.248	-3.345	1.91e-03	5.78e-02	-1.360	glutamyl-tRNA(Gln) amidotransferase subunit A	GATA
106	PF3D7_0700100	Pf3D7_07_v3	20307	+	7777	-1.044	-1.871	-0.217	5.158	-3.344	1.93e-03	5.78e-02	-1.411	erythrocyte membrane protein 1, PfEMP1	VAR
203	PF3D7_1103400	Pf3D7_11_v3	146427	+	4389	1.198	-0.028	2.425	3.263	3.343	1.93e-03	5.78e-02	-1.310	FeS cluster assembly protein SufD, putative	SufD
42	PF3D7_0405400	Pf3D7_04_v3	291251	+	9726	-0.562	-1.533	0.410	10.748	-3.333	1.97e-03	5.87e-02	-1.665	pre-mRNA-processing-splicing factor 8, putative	PRPF8
56	PF3D7_0421300	Pf3D7_04_v3	969031	-	7561	-1.056	-1.582	-0.531	4.877	-3.320	2.05e-03	5.87e-02	-1.447	erythrocyte membrane protein 1, PfEMP1	VAR
247	PF3D7_1226600	Pf3D7_12_v3	1077868	-	909	1.498	0.096	2.900	-0.283	3.319	2.05e-03	5.87e-02	-1.406	proliferating cell nuclear antigen 2	PCNA2
255	PF3D7_1234500	Pf3D7_12_v3	1439896	-	1155	0.626	0.114	1.138	4.918	3.325	2.02e-03	5.87e-02	-1.435	conserved Plasmodium protein, unknown function	NA
308	PF3D7_1364000	Pf3D7_13_v3	2564625	+	2484	0.987	0.420	1.554	3.797	3.328	2.01e-03	5.87e-02	-1.369	conserved Plasmodium protein, unknown function	NA
313	PF3D7_1372100	Pf3D7_13_v3	2837053	+	2006	3.129	2.299	3.958	1.578	3.365	2.06e-03	5.87e-02	-1.336	Plasmodium exported protein (PHISTb), unknown function	GEXP04
339	PF3D7_1445800	Pf3D7_14_v3	1878658	-	3920	1.067	0.776	1.358	1.539	3.321	2.05e-03	5.87e-02	-1.355	conserved Plasmodium membrane protein, unknown function	NA
280	PF3D7_1307700	Pf3D7_13_v3	344525	+	3708	0.582	-0.368	1.531	6.383	3.313	2.09e-03	5.94e-02	-1.581	conserved Plasmodium protein, unknown function	NA
109	PF3D7_0703400	Pf3D7_07_v3	129370	-	2463	1.161	0.838	1.484	3.395	3.307	2.12e-03	5.99e-02	-1.406	conserved Plasmodium protein, unknown function	NA
183	PF3D7_1016100	Pf3D7_10_v3	643558	-	774	1.160	0.663	1.658	0.683	3.303	2.15e-03	6.01e-02	-1.409	conserved Plasmodium protein, unknown function	NA
358	PF3D7_1477700	Pf3D7_14_v3	3202931	+	1087	2.091	1.317	2.865	1.770	3.316	2.17e-03	6.04e-02	-1.395	Plasmodium exported protein (PHISTa), unknown function	Pfg14-748
64	PF3D7_0508700	Pf3D7_05_v3	358261	+	4473	-0.499	-1.326	0.327	7.639	-3.287	2.24e-03	6.05e-02	-1.721	pre-mRNA-processing ATP-dependent RNA helicase PRP5, putative	PRP5
144	PF3D7_0814100	Pf3D7_08_v3	682518	-	1055	0.938	-0.783	2.659	4.348	3.287	2.24e-03	6.05e-02	-1.492	conserved Plasmodium protein, unknown function	NA
178	PF3D7_1009300	Pf3D7_10_v3	377906	-	1803	1.211	0.885	1.536	3.019	3.287	2.24e-03	6.05e-02	-1.441	conserved Plasmodium protein, unknown function	NA
295	PF3D7_1344200	Pf3D7_13_v3	1769129	+	2799	-0.564	-1.236	0.108	9.434	-3.286	2.25e-03	6.05e-02	-1.777	heat shock protein 110, putative	HSP110
330	PF3D7_1427200	Pf3D7_14_v3	1061805	+	975	-1.619	-2.155	-1.082	1.505	-3.289	2.25e-03	6.05e-02	-1.430	selenoprotein	Sel4
44	PF3D7_0412400	Pf3D7_04_v3	545987	-	7824	-0.919	-1.577	-0.261	3.465	-3.283	2.27e-03	6.06e-02	-1.458	erythrocyte membrane protein 1, PfEMP1	VAR
32	PF3D7_0317100	Pf3D7_03_v3	686282	+	3201	0.874	0.596	1.152	2.504	3.274	2.33e-03	6.06e-02	-1.464	6-cysteine protein	B9
82	PF3D7_0531000	Pf3D7_05_v3	1267410	+	2130	0.713	-0.601	2.027	4.964	3.276	2.31e-03	6.06e-02	-1.559	conserved Plasmodium protein, unknown function	NA
134	PF3D7_0800300	Pf3D7_08_v3	40948	+	9992	-1.073	-1.392	-0.753	5.027	-3.282	2.29e-03	6.06e-02	-1.553	erythrocyte membrane protein 1, PfEMP1	VAR
289	PF3D7_1321700	Pf3D7_13_v3	902383	+	2784	-0.538	-0.896	-0.181	9.122	-3.276	2.31e-03	6.06e-02	-1.799	splicing factor 1	SF1
273	PF3D7_1302700	Pf3D7_13_v3	145174	+	5025	-0.474	-1.190	0.241	8.882	-3.270	2.35e-03	6.09e-02	-1.808	ATP-dependent RNA helicase DHR1, putative	NA
169	PF3D7_0926500	Pf3D7_09_v3	1075915	-	5769	1.173	0.733	1.614	0.469	3.256	2.44e-03	6.26e-02	-1.518	conserved Plasmodium protein, unknown function	NA
221	PF3D7_1128100	Pf3D7_11_v3	1094909	-	1023	-0.703	-1.004	-0.402	5.252	-3.253	2.46e-03	6.26e-02	-1.636	prefoldin subunit 5, putative	NA
233	PF3D7_1205700	Pf3D7_12_v3	253155	+	969	1.229	0.775	1.684	0.855	3.254	2.45e-03	6.26e-02	-1.515	targeted glyoxalase II	tGloII
17	PF3D7_0209700	Pf3D7_02_v3	400153	-	1707	0.555	-0.119	1.228	8.789	3.232	2.61e-03	6.32e-02	-1.899	RING zinc finger protein, putative	NA
22	PF3D7_0220500	Pf3D7_02_v3	823825	-	1040	-0.875	-2.077	0.327	6.458	-3.238	2.57e-03	6.32e-02	-1.757	Plasmodium exported protein (hyp2), unknown function	NA
87	PF3D7_0606800	Pf3D7_06_v3	288377	-	900	1.551	1.311	1.791	3.382	3.241	2.60e-03	6.32e-02	-1.573	probable protein, unknown function	NA
130	PF3D7_0723900	Pf3D7_07_v3	1000701	-	4046	-0.612	-0.899	-0.325	7.826	-3.238	2.57e-03	6.32e-02	-1.851	RNA-binding protein, putative	NA
187	PF3D7_1021900	Pf3D7_10_v3	905473	-	6873	-0.993	-1.349	-0.638	6.736	-3.246	2.57e-03	6.32e-02	-1.784	PHAX domain-containing protein, putative	NA
199	PF3D7_1100300	Pf3D7_11_v3	45056	+	1178	1.993	1.575	2.412	-0.537	3.236	2.60e-03	6.32e-02	-1.598	rifin	RIF
241	PF3D7_1217000	Pf3D7_12_v3	674349	-	429	1.119	0.313	1.924	1.672	3.236	2.58e-03	6.32e-02	-1.546	conserved Plasmodium protein, unknown function	NA
317	PF3D7_1401600	Pf3D7_14_v3	61364	-	1625	-0.760	-1.042	-0.478	8.852	-3.236	2.61e-03	6.32e-02	-1.901	Plasmodium exported protein (PHISTb), unknown function	NA
70	PF3D7_0518300	Pf3D7_05_v3	759831	-	1168	-0.484	-0.912	-0.056	6.571	-3.226	2.65e-03	6.33e-02	-1.809	proteasome subunit beta type-1, putative	NA
72	PF3D7_0521000	Pf3D7_05_v3	859373	-	1691	-0.687	-1.390	0.017	5.971	-3.225	2.66e-03	6.33e-02	-1.762	conserved Plasmodium protein, unknown function	NA
98	PF3D7_0621500	Pf3D7_06_v3	881963	+	1032	1.065	0.072	2.058	1.161	3.225	2.65e-03	6.33e-02	-1.574	ribonuclease P/MRP protein subunit RPP1, putative	RPP1
174	PF3D7_0936800	Pf3D7_09_v3	1458392	+	1471	-0.876	-1.190	-0.562	10.878	-3.220	2.77e-03	6.48e-02	-1.957	Plasmodium exported protein (PHISTc), unknown function	NA
181	PF3D7_1013000	Pf3D7_10_v3	500210	+	2012	1.140	0.529	1.751	2.844	3.208	2.78e-03	6.48e-02	-1.624	zinc finger protein, putative	NA
184	PF3D7_1016200	Pf3D7_10_v3	646054	+	1683	1.055	0.321	1.789	4.570	3.206	2.80e-03	6.48e-02	-1.710	Rab3 GTPase-activating protein non-catalytic subunit, putative	NA
227	PF3D7_1140800	Pf3D7_11_v3	1633920	+	2412	0.505	-0.045	1.055	6.676	3.212	2.75e-03	6.48e-02	-1.849	conserved Plasmodium protein, unknown function	NA
230	PF3D7_1149500	Pf3D7_11_v3	1991359	-	2660	-0.653	-1.498	0.192	8.007	-3.204	2.81e-03	6.48e-02	-1.927	ring-infected erythrocyte surface antigen 2, pseudogene	RESA2
319	PF3D7_1410500	Pf3D7_14_v3	423751	-	500	1.042	0.705	1.378	1.400	3.205	2.80e-03	6.48e-02	-1.618	conserved Plasmodium protein, unknown function	NA
104	PF3D7_0631600	Pf3D7_06_v3	1323294	+	1142	-1.234	-1.641	-0.828	2.559	-3.201	2.83e-03	6.49e-02	-1.631	exported protein family 4	EPF4
323	PF3D7_1414500	Pf3D7_14_v3	578369	-	9161	-0.636	-0.920	-0.351	7.984	-3.197	2.86e-03	6.52e-02	-1.965	atypical protein kinase, ABC-1 family, putative	ABCk2
12	PF3D7_0201800	Pf3D7_02_v3	86832	-	1960	-0.527	-0.803	-0.252	9.437	-3.178	3.02e-03	6.61e-02	-2.046	knob associated heat shock protein 40	KAHsp40
33	PF3D7_0317500	Pf3D7_03_v3	716523	-	5309	0.587	-0.080	1.253	7.115	3.180	3.00e-03	6.61e-02	-1.961	kinesin-5	EG5
52	PF3D7_0418300	Pf3D7_04_v3	819362	-	2979	0.610	0.114	1.106	10.470	3.186	2.95e-03	6.61e-02	-2.036	conserved Plasmodium protein, unknown function	NA
67	PF3D7_0511000	Pf3D7_05_v3	467585	-	516	-0.538	-0.738	-0.337	8.120	-3.185	2.96e-03	6.61e-02	-1.988	translationally-controlled tumor protein homolog	TCTP
263	PF3D7_1244300	Pf3D7_12_v3	1857849	+	242	-1.945	-2.961	-0.930	2.568	-3.199	2.97e-03	6.61e-02	-1.662	ACEA small nucleolar RNA U3	NA
277	PF3D7_1304300	Pf3D7_13_v3	231083	+	642	1.477	0.660	2.294	0.552	3.180	3.00e-03	6.61e-02	-1.683	conserved Plasmodium protein, unknown function	NA
278	PF3D7_1305400	Pf3D7_13_v3	268785	-	1953	0.561	0.218	0.904	5.309	3.182	2.98e-03	6.61e-02	-1.821	AAR2 protein, putative	NA
34	PF3D7_0319600	Pf3D7_03_v3	817913	+	783	-0.442	-0.957	0.073	8.336	-3.170	3.08e-03	6.72e-02	-2.045	elongation factor 1 (EF-1), putative	NA
195	PF3D7_1035800	Pf3D7_10_v3	1420533	+	2139	-1.293	-1.677	-0.909	9.469	-3.201	3.10e-03	6.72e-02	-2.007	probable protein, unknown function	M712
283	PF3D7_1309400	Pf3D7_13_v3	431892	+	3984	-0.750	-1.414	-0.086	5.757	-3.166	3.12e-03	6.72e-02	-1.885	HORMA domain protein, putative	NA
173	PF3D7_0935900	Pf3D7_09_v3	1420483	-	2325	-0.762	-1.083	-0.440	13.744	-3.169	3.13e-03	6.73e-02	-2.072	ring-exported protein 1	REX1
152	PF3D7_0829100	Pf3D7_08_v3	1252349	+	1448	-0.521	-1.286	0.244	7.060	-3.160	3.16e-03	6.75e-02	-2.006	conserved protein, unknown function	NA
222	PF3D7_1133000	Pf3D7_11_v3	1275574	+	90	1.310	0.942	1.678	0.955	3.158	3.18e-03	6.77e-02	-1.727	conserved Plasmodium protein, unknown function	NA
16	PF3D7_0205400	Pf3D7_02_v3	223478	+	1374	0.446	0.105	0.787	6.179	3.149	3.26e-03	6.80e-02	-1.969	PCI domain-containing protein, putative	NA
55	PF3D7_0420000	Pf3D7_04_v3	894612	-	10113	-0.524	-1.375	0.327	9.311	-3.146	3.29e-03	6.80e-02	-2.125	zinc finger protein, putative	NA
182	PF3D7_1015800	Pf3D7_10_v3	633682	+	1605	1.197	0.525	1.870	0.318	3.151	3.24e-03	6.80e-02	-1.749	ribonucleoside-diphosphate reductase small chain, putative	NA
258	PF3D7_1240400	Pf3D7_12_v3	1704512	+	7979	-0.936	-1.157	-0.715	4.827	-3.148	3.27e-03	6.80e-02	-1.857	erythrocyte membrane protein 1, PfEMP1	VAR
355	PF3D7_1468100	Pf3D7_14_v3	2786308	-	8016	-0.558	-0.954	-0.161	10.206	-3.146	3.28e-03	6.80e-02	-2.133	conserved Plasmodium protein, unknown function	NA
357	PF3D7_1472300	Pf3D7_14_v3	2954108	+	3001	1.050	0.167	1.932	4.451	3.145	3.30e-03	6.80e-02	-1.843	conserved Plasmodium membrane protein, unknown function	NA
66	PF3D7_0509800	Pf3D7_05_v3	410268	+	5041	-0.385	-0.757	-0.013	8.254	-3.141	3.33e-03	6.80e-02	-2.114	phosphatidylinositol 4-kinase	PI4K
232	PF3D7_1200200	Pf3D7_12_v3	26321	-	1367	-1.845	-2.273	-1.417	-0.252	-3.141	3.33e-03	6.80e-02	-1.797	rifin	RIF
226	PF3D7_1140200	Pf3D7_11_v3	1601257	-	1822	-1.160	-1.579	-0.742	3.820	-3.140	3.35e-03	6.81e-02	-1.826	conserved Plasmodium protein, unknown function	NA
348	PF3D7_1457100	Pf3D7_14_v3	2340784	+	2244	-0.895	-1.549	-0.240	6.629	-3.139	3.39e-03	6.85e-02	-2.013	conserved Plasmodium protein, unknown function	NA
200	PF3D7_1102600	Pf3D7_11_v3	123818	-	919	1.461	0.883	2.039	2.317	3.132	3.43e-03	6.91e-02	-1.791	Plasmodium exported protein, unknown function	GEXP14
112	PF3D7_0705600	Pf3D7_07_v3	281035	-	3399	0.833	0.363	1.303	3.988	3.125	3.48e-03	6.96e-02	-1.857	RNA helicase, putative	NA
352	PF3D7_1460500	Pf3D7_14_v3	2466091	+	4899	1.016	0.429	1.604	2.431	3.123	3.49e-03	6.96e-02	-1.807	conserved Plasmodium protein, unknown function	NA
3	PF3D7_0101000	Pf3D7_01_v3	65817	-	1173	-2.246	-2.928	-1.565	-1.073	-3.119	3.57e-03	7.06e-02	-1.882	rifin	RIF
90	PF3D7_0609700	Pf3D7_06_v3	413652	+	6130	-0.563	-1.557	0.430	9.552	-3.111	3.61e-03	7.06e-02	-2.211	conserved Plasmodium protein, unknown function	NA
186	PF3D7_1019300	Pf3D7_10_v3	774929	-	5559	0.842	0.580	1.103	4.369	3.114	3.58e-03	7.06e-02	-1.903	zinc finger protein, putative	NA
272	PF3D7_1301400	Pf3D7_13_v3	82718	+	1301	-0.891	-1.162	-0.619	8.053	-3.118	3.61e-03	7.06e-02	-2.129	Plasmodium exported protein (hyp12), unknown function	HYP12
165	PF3D7_0915500	Pf3D7_09_v3	657418	+	1995	1.320	0.789	1.851	0.044	3.109	3.63e-03	7.07e-02	-1.847	conserved Plasmodium protein, unknown function	NA
123	PF3D7_0713500	Pf3D7_07_v3	614385	+	2865	0.925	0.534	1.316	4.314	3.100	3.72e-03	7.07e-02	-1.938	conserved Plasmodium protein, unknown function	NA
141	PF3D7_0808700	Pf3D7_08_v3	440408	+	7655	-0.981	-1.345	-0.618	4.547	-3.102	3.69e-03	7.07e-02	-1.952	erythrocyte membrane protein 1, PfEMP1	VAR
145	PF3D7_0817100	Pf3D7_08_v3	774299	+	2493	1.043	0.215	1.870	0.070	3.101	3.70e-03	7.07e-02	-1.864	tRNA modification GTPase, putative	NA
162	PF3D7_0913100	Pf3D7_09_v3	571031	-	2319	1.169	0.432	1.905	-0.164	3.102	3.69e-03	7.07e-02	-1.865	conserved Plasmodium protein, unknown function	NA
345	PF3D7_1451100	Pf3D7_14_v3	2090902	+	2499	-0.648	-1.295	-0.001	12.559	-3.105	3.67e-03	7.07e-02	-2.231	elongation factor 2	eEF2
281	PF3D7_1308300	Pf3D7_13_v3	372260	+	387	0.444	-0.083	0.971	7.958	3.092	3.80e-03	7.19e-02	-2.222	40S ribosomal protein S27	RPS27
27	PF3D7_0304900	Pf3D7_03_v3	231793	-	513	0.801	0.116	1.486	5.085	3.080	3.92e-03	7.22e-02	-2.035	conserved Plasmodium protein, unknown function	NA
76	PF3D7_0524800	Pf3D7_05_v3	1021408	-	2900	0.882	0.028	1.736	3.247	3.087	3.84e-03	7.22e-02	-1.915	ubiquitin fusion degradation protein 1, putative	UFD1
225	PF3D7_1137300	Pf3D7_11_v3	1466197	-	2070	0.450	-0.267	1.166	7.350	3.080	3.92e-03	7.22e-02	-2.218	CLPTM1 domain-containing protein, putative	NA
252	PF3D7_1231600	Pf3D7_12_v3	1301098	-	3507	-0.706	-1.747	0.336	6.288	-3.084	3.88e-03	7.22e-02	-2.140	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP2, putative	PRP2
282	PF3D7_1309100	Pf3D7_13_v3	418820	+	1302	-0.722	-1.280	-0.165	8.832	-3.088	3.87e-03	7.22e-02	-2.267	60S ribosomal protein L24, putative	NA
291	PF3D7_1324200	Pf3D7_13_v3	1000100	-	1783	-0.797	-1.141	-0.454	7.145	-3.086	3.89e-03	7.22e-02	-2.192	micro-fibrillar-associated protein, putative	NA
119	PF3D7_0712300	Pf3D7_07_v3	542906	-	7615	-1.223	-2.264	-0.181	3.752	-3.079	3.97e-03	7.25e-02	-1.970	erythrocyte membrane protein 1, PfEMP1	VAR
307	PF3D7_1362300	Pf3D7_13_v3	2493143	+	570	0.782	-0.312	1.876	3.668	3.075	3.97e-03	7.25e-02	-1.960	conserved protein, unknown function	NA
240	PF3D7_1215900	Pf3D7_12_v3	641552	+	1968	0.743	0.298	1.187	4.806	3.068	4.04e-03	7.35e-02	-2.053	serpentine receptor, putative	SR10
20	PF3D7_0216400	Pf3D7_02_v3	675431	+	2169	0.789	0.122	1.457	0.530	3.064	4.09e-03	7.37e-02	-1.935	vacuolar protein sorting-associated protein 45, putative	VPS45
172	PF3D7_0932900	Pf3D7_09_v3	1309467	-	477	0.939	0.530	1.349	2.103	3.065	4.08e-03	7.37e-02	-1.934	conserved Plasmodium protein, unknown function	NA
292	PF3D7_1326700	Pf3D7_13_v3	1125280	+	1629	1.336	0.904	1.768	3.634	3.063	4.16e-03	7.46e-02	-1.997	conserved Apicomplexan protein, unknown function	NA
160	PF3D7_0907900	Pf3D7_09_v3	367865	-	925	-1.480	-2.225	-0.735	3.656	-3.067	4.19e-03	7.48e-02	-2.006	peptide deformylase	PDF
333	PF3D7_1434300	Pf3D7_14_v3	1372903	+	1695	-0.408	-1.424	0.608	8.746	-3.050	4.25e-03	7.55e-02	-2.352	Hsp70/Hsp90 organizing protein	HOP
353	PF3D7_1462800	Pf3D7_14_v3	2559098	+	1250	-0.693	-1.932	0.546	13.081	-3.050	4.27e-03	7.56e-02	-2.364	glyceraldehyde-3-phosphate dehydrogenase	GAPDH
5	PF3D7_0108500	Pf3D7_01_v3	349170	+	540	-0.875	-2.335	0.586	10.163	-3.051	4.39e-03	7.58e-02	-2.381	conserved Plasmodium protein, unknown function	NA
10	PF3D7_0200100	Pf3D7_02_v3	25232	+	5937	-1.299	-2.059	-0.540	3.963	-3.049	4.33e-03	7.58e-02	-2.044	erythrocyte membrane protein 1, PfEMP1	VAR
214	PF3D7_1122300	Pf3D7_11_v3	846929	+	1086	0.944	0.421	1.466	3.809	3.043	4.32e-03	7.58e-02	-2.047	conserved Plasmodium protein, unknown function	NA
215	PF3D7_1122900	Pf3D7_11_v3	878969	+	16305	-1.086	-1.508	-0.664	1.411	-3.039	4.37e-03	7.58e-02	-1.988	dynein heavy chain, putative	NA
254	PF3D7_1233100	Pf3D7_12_v3	1359169	+	408	-0.794	-1.469	-0.119	4.068	-3.041	4.35e-03	7.58e-02	-2.051	conserved protein, unknown function	NA
270	PF3D7_1253100	Pf3D7_12_v3	2171342	+	1008	0.614	0.151	1.077	6.992	3.039	4.37e-03	7.58e-02	-2.295	Plasmodium exported protein (PHISTa), unknown function	NA
115	PF3D7_0709600	Pf3D7_07_v3	429857	-	3902	-0.489	-0.848	-0.129	7.337	-3.035	4.41e-03	7.59e-02	-2.325	ribonucleases P/MRP protein subunit POP1, putative	POP1
223	PF3D7_1133700	Pf3D7_11_v3	1302173	+	3815	-0.680	-1.110	-0.249	10.033	-3.034	4.46e-03	7.60e-02	-2.412	FHA domain-containing protein, putative	NA
264	PF3D7_1244800	Pf3D7_12_v3	1873194	-	2094	-0.452	-2.303	1.399	7.567	-3.030	4.48e-03	7.60e-02	-2.356	cytoplasmic translation machinery associated protein, putative	NA
269	PF3D7_1251400	Pf3D7_12_v3	2097436	-	1410	1.035	0.691	1.379	1.657	3.031	4.46e-03	7.60e-02	-2.004	conserved Plasmodium protein, unknown function	NA
48	PF3D7_0415300	Pf3D7_04_v3	681810	+	4159	-0.547	-0.925	-0.169	8.627	-3.020	4.59e-03	7.68e-02	-2.419	cdc2-related protein kinase 3	CRK3
108	PF3D7_0703200	Pf3D7_07_v3	122513	-	4623	-0.955	-1.527	-0.383	4.508	-3.017	4.63e-03	7.68e-02	-2.153	conserved Plasmodium protein, unknown function	NA
118	PF3D7_0712000	Pf3D7_07_v3	527338	-	7794	-1.572	-1.966	-1.178	3.236	-3.029	4.61e-03	7.68e-02	-2.059	erythrocyte membrane protein 1, PfEMP1	VAR
155	PF3D7_0833500	Pf3D7_08_v3	1435794	-	7656	-0.978	-1.408	-0.547	4.340	-3.022	4.57e-03	7.68e-02	-2.123	erythrocyte membrane protein 1, PfEMP1	VAR
188	PF3D7_1023000	Pf3D7_10_v3	961066	-	1242	0.838	0.065	1.610	1.337	3.016	4.65e-03	7.68e-02	-2.035	conserved Plasmodium membrane protein, unknown function	NA
300	PF3D7_1347500	Pf3D7_13_v3	1897983	-	1380	-0.472	-0.748	-0.196	12.054	-3.015	4.65e-03	7.68e-02	-2.454	DNA/RNA-binding protein Alba 4	ALBA4
318	PF3D7_1404900	Pf3D7_14_v3	170000	+	894	0.405	-0.046	0.855	8.338	3.020	4.59e-03	7.68e-02	-2.410	conserved Plasmodium protein, unknown function	NA
92	PF3D7_0613600	Pf3D7_06_v3	554457	+	3772	1.236	0.284	2.188	0.053	3.009	4.73e-03	7.71e-02	-2.056	conserved Plasmodium protein, unknown function	NA
125	PF3D7_0716000	Pf3D7_07_v3	703207	+	3378	-0.490	-0.849	-0.130	8.568	-3.008	4.74e-03	7.71e-02	-2.448	RNA-binding protein, putative	NA
167	PF3D7_0923100	Pf3D7_09_v3	941830	-	669	1.113	0.506	1.720	1.302	3.009	4.73e-03	7.71e-02	-2.049	OTU domain-containing protein, putative	NA
239	PF3D7_1214600	Pf3D7_12_v3	613561	-	1014	-0.563	-1.043	-0.084	4.766	-3.012	4.70e-03	7.71e-02	-2.178	adrenodoxin-type ferredoxin, putative	NA
100	PF3D7_0625400	Pf3D7_06_v3	1032536	-	1239	0.554	-0.780	1.888	7.778	3.005	4.77e-03	7.73e-02	-2.416	conserved Plasmodium protein, unknown function	NA
79	PF3D7_0528100	Pf3D7_05_v3	1157840	-	3714	-0.377	-1.096	0.342	9.370	-2.997	4.88e-03	7.81e-02	-2.490	AP-1 complex subunit beta, putative	NA
191	PF3D7_1025500	Pf3D7_10_v3	1067652	-	19341	-1.108	-1.901	-0.316	0.450	-2.998	4.86e-03	7.81e-02	-2.074	conserved Plasmodium protein, unknown function	NA
194	PF3D7_1030100	Pf3D7_10_v3	1224519	-	4574	-0.406	-1.677	0.865	8.759	-2.997	4.88e-03	7.81e-02	-2.478	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative	PRP22
77	PF3D7_0527500	Pf3D7_05_v3	1143618	+	1742	-0.398	-1.848	1.052	9.586	-2.992	4.94e-03	7.83e-02	-2.505	Hsc70-interacting protein	HIP
131	PF3D7_0724000	Pf3D7_07_v3	1006335	+	5811	0.875	0.418	1.332	2.241	2.994	4.92e-03	7.83e-02	-2.094	Rab GTPase activator and protein kinase, putative	NA
268	PF3D7_1250800	Pf3D7_12_v3	2077718	+	5170	-0.475	-0.773	-0.177	6.852	-2.991	4.95e-03	7.83e-02	-2.402	DNA repair protein rhp16, putative	NA
340	PF3D7_1446300	Pf3D7_14_v3	1898351	+	3576	1.129	0.535	1.724	4.066	2.990	5.01e-03	7.90e-02	-2.191	conserved Plasmodium membrane protein, unknown function	NA
179	PF3D7_1011800	Pf3D7_10_v3	455398	+	3420	-0.579	-1.305	0.146	10.624	-2.984	5.04e-03	7.92e-02	-2.531	PRE-binding protein	PREBP
274	PF3D7_1302900	Pf3D7_13_v3	154992	+	2403	1.025	0.147	1.903	3.537	2.980	5.10e-03	7.98e-02	-2.176	conserved Plasmodium protein, unknown function	NA
235	PF3D7_1208600	Pf3D7_12_v3	402300	+	228	-0.700	-1.229	-0.171	3.757	-2.977	5.15e-03	8.00e-02	-2.206	mitochondrial import inner membrane translocase subunit TIM10, putative	TIM10
284	PF3D7_1309600	Pf3D7_13_v3	438510	+	867	0.727	0.325	1.129	4.309	2.976	5.15e-03	8.00e-02	-2.227	ribosomal RNA methyltransferase, putative	NA
11	PF3D7_0201600	Pf3D7_02_v3	77251	-	1558	-0.649	-1.469	0.172	9.150	-2.971	5.23e-03	8.01e-02	-2.534	PHISTb domain-containing RESA-like protein 1	RLP1
18	PF3D7_0211800	Pf3D7_02_v3	475242	+	1833	-0.643	-1.218	-0.068	9.283	-2.961	5.37e-03	8.01e-02	-2.576	asparagine–tRNA ligase	AsnRS
97	PF3D7_0621300	Pf3D7_06_v3	873809	+	2382	0.443	-0.422	1.307	7.592	2.960	5.37e-03	8.01e-02	-2.519	mRNA binding Pumilio-homology domain protein, putative	NA
129	PF3D7_0719900	Pf3D7_07_v3	865927	+	10206	-0.417	-1.081	0.248	7.724	-2.959	5.39e-03	8.01e-02	-2.534	conserved Plasmodium membrane protein, unknown function	NA
135	PF3D7_0801700	Pf3D7_08_v3	112299	+	5579	-0.589	-0.932	-0.246	6.129	-2.966	5.29e-03	8.01e-02	-2.408	sentrin-specific protease 2, putative	SENP2
137	PF3D7_0804700	Pf3D7_08_v3	271417	-	5997	-0.573	-1.463	0.317	5.755	-2.962	5.34e-03	8.01e-02	-2.382	conserved Plasmodium protein, unknown function	NA
159	PF3D7_0907700	Pf3D7_09_v3	364069	-	840	0.415	0.186	0.645	7.929	2.970	5.23e-03	8.01e-02	-2.513	subunit of proteaseome activator complex, putative	PA28
217	PF3D7_1124100	Pf3D7_11_v3	951382	-	4962	-0.411	-0.946	0.123	8.014	-2.963	5.34e-03	8.01e-02	-2.538	beige/BEACH domain protein, putative	NA
256	PF3D7_1235300	Pf3D7_12_v3	1470713	+	4989	-0.568	-1.359	0.222	9.292	-2.966	5.29e-03	8.01e-02	-2.560	CCR4-NOT transcription complex subunit 4, putative	NOT4
301	PF3D7_1350100	Pf3D7_13_v3	2005962	-	1989	-0.430	-1.427	0.567	9.206	-2.962	5.34e-03	8.01e-02	-2.572	lysine–tRNA ligase	KRS1
312	PF3D7_1366500	Pf3D7_13_v3	2661573	+	450	1.090	0.675	1.506	0.730	2.968	5.26e-03	8.01e-02	-2.136	nucleoside diphosphate kinase	NDK
350	PF3D7_1458000	Pf3D7_14_v3	2387786	+	1710	0.339	-0.118	0.796	8.196	2.974	5.19e-03	8.01e-02	-2.513	cysteine proteinase falcipain 1	FP1
61	PF3D7_0502500	Pf3D7_05_v3	114149	+	1785	1.611	0.861	2.360	0.201	2.957	5.42e-03	8.02e-02	-2.162	conserved Plasmodium protein, unknown function	NA
354	PF3D7_1466300	Pf3D7_14_v3	2709418	+	3775	-0.392	-1.138	0.353	9.366	-2.954	5.46e-03	8.05e-02	-2.594	26S proteasome regulatory subunit RPN2, putative	RPN2
151	PF3D7_0826900	Pf3D7_08_v3	1164655	+	2551	0.987	0.185	1.788	3.078	2.949	5.54e-03	8.14e-02	-2.215	conserved Plasmodium protein, unknown function	NA
80	PF3D7_0528800	Pf3D7_05_v3	1180425	-	1614	0.476	-0.329	1.281	6.073	2.942	5.64e-03	8.23e-02	-2.454	nucleolar preribosomal GTPase, putative	NA
257	PF3D7_1239800	Pf3D7_12_v3	1660451	+	17304	-1.106	-1.531	-0.682	3.686	-2.944	5.62e-03	8.23e-02	-2.275	conserved Plasmodium protein, unknown function	NA
39	PF3D7_0404300	Pf3D7_04_v3	234014	-	3000	-0.853	-1.708	0.001	7.533	-2.947	5.68e-03	8.23e-02	-2.559	conserved Plasmodium protein, unknown function	NA
185	PF3D7_1019100	Pf3D7_10_v3	766168	-	5787	-1.392	-1.726	-1.058	0.749	-2.939	5.67e-03	8.23e-02	-2.197	conserved Plasmodium protein, unknown function	NA
304	PF3D7_1355200	Pf3D7_13_v3	2191058	-	3054	1.630	0.890	2.370	0.536	2.939	5.71e-03	8.24e-02	-2.201	RAP protein, putative	NA
328	PF3D7_1424500	Pf3D7_14_v3	979464	+	142	-0.825	-1.714	0.063	3.590	-2.929	5.82e-03	8.37e-02	-2.272	small nucleolar RNA snoR27	NA
293	PF3D7_1338600	Pf3D7_13_v3	1556659	-	3076	1.267	0.697	1.837	0.039	2.928	5.85e-03	8.39e-02	-2.223	conserved Plasmodium protein, unknown function	NA
311	PF3D7_1366000	Pf3D7_13_v3	2635213	+	276	1.117	0.785	1.450	2.202	2.924	5.91e-03	8.45e-02	-2.247	conserved Plasmodium protein, unknown function	NA
236	PF3D7_1210300	Pf3D7_12_v3	465115	+	630	0.713	-0.071	1.498	3.554	2.919	5.97e-03	8.51e-02	-2.309	conserved Plasmodium protein, unknown function	NA
249	PF3D7_1228900	Pf3D7_12_v3	1180670	-	4814	-0.607	-1.072	-0.142	6.434	-2.916	6.03e-03	8.56e-02	-2.550	conserved Plasmodium protein, unknown function	NA
8	PF3D7_0115200	Pf3D7_01_v3	591849	+	1339	-2.053	-3.146	-0.961	-0.691	-2.917	6.08e-03	8.59e-02	-2.271	rifin	RIF
30	PF3D7_0311700	Pf3D7_03_v3	502698	+	3151	-1.459	-2.316	-0.601	0.983	-2.910	6.12e-03	8.59e-02	-2.258	plasmepsin VI	NA
46	PF3D7_0412900	Pf3D7_04_v3	576810	-	7859	-1.189	-1.516	-0.862	2.611	-2.911	6.10e-03	8.59e-02	-2.283	erythrocyte membrane protein 1, PfEMP1	VAR
43	PF3D7_0411900	Pf3D7_04_v3	528192	-	6294	-0.914	-1.287	-0.541	1.934	-2.905	6.20e-03	8.62e-02	-2.287	DNA polymerase alpha catalytic subunit A	NA
201	PF3D7_1102700	Pf3D7_11_v3	128789	+	276	-0.587	-0.982	-0.192	10.475	-2.905	6.20e-03	8.62e-02	-2.719	early transcribed membrane protein 11.1	ETRAMP11.1
279	PF3D7_1306400	Pf3D7_13_v3	297178	-	1182	-0.466	-1.327	0.396	7.247	-2.904	6.22e-03	8.62e-02	-2.626	26S protease regulatory subunit 10B, putative	RPT4
302	PF3D7_1353500	Pf3D7_13_v3	2144125	+	981	0.778	0.133	1.423	3.030	2.907	6.17e-03	8.62e-02	-2.313	RNA polymerase II transcription factor B subunit 4, putative	TFB4
2	mal_rna_17:rRNA	M76611	5577	-	195	-1.264	-1.671	-0.857	4.223	-2.903	6.33e-03	8.72e-02	-2.371	NA	NA
196	PF3D7_1037900	Pf3D7_10_v3	1502955	-	1368	1.025	0.342	1.708	2.136	2.897	6.34e-03	8.72e-02	-2.307	conserved Plasmodium protein, unknown function	NA
164	PF3D7_0915100	Pf3D7_09_v3	643232	-	812	-0.531	-1.152	0.090	6.543	-2.889	6.46e-03	8.87e-02	-2.619	SUMO-conjugating enzyme UBC9	UBC9
35	PF3D7_0323000	Pf3D7_03_v3	968675	-	528	-0.901	-1.197	-0.604	4.269	-2.885	6.53e-03	8.91e-02	-2.456	translation machinery-associated protein 7, putative	TMA7
309	PF3D7_1365000	Pf3D7_13_v3	2608698	+	1047	-0.839	-1.102	-0.577	3.815	-2.886	6.52e-03	8.91e-02	-2.386	conserved Plasmodium protein, unknown function	NA
60	PF3D7_0501400	Pf3D7_05_v3	74509	+	5334	-1.045	-1.303	-0.787	10.998	-2.901	6.65e-03	8.95e-02	-2.757	interspersed repeat antigen	FIRA
75	PF3D7_0523700	Pf3D7_05_v3	980754	-	4601	1.308	0.350	2.266	0.920	2.876	6.69e-03	8.95e-02	-2.331	conserved Plasmodium membrane protein, unknown function	NA
86	PF3D7_0601600	Pf3D7_06_v3	68833	-	861	1.227	-0.183	2.636	1.035	2.873	6.74e-03	8.95e-02	-2.337	tetratricopeptide repeat protein, putative	NA
93	PF3D7_0613900	Pf3D7_06_v3	579435	-	6462	1.190	-0.386	2.767	0.943	2.874	6.72e-03	8.95e-02	-2.334	myosin E, putative	myoE
96	PF3D7_0618200	Pf3D7_06_v3	764667	-	826	-0.533	-1.152	0.086	7.015	-2.871	6.78e-03	8.95e-02	-2.700	conserved Plasmodium protein, unknown function	NA
101	PF3D7_0625600	Pf3D7_06_v3	1039655	+	1896	0.840	-0.298	1.979	5.615	2.878	6.67e-03	8.95e-02	-2.563	poly(A) polymerase PAP, putative	NA
163	PF3D7_0913200	Pf3D7_09_v3	575679	+	831	-0.503	-1.221	0.215	8.866	-2.871	6.77e-03	8.95e-02	-2.781	elongation factor 1-beta	EF-1beta
228	PF3D7_1142400	Pf3D7_11_v3	1702089	-	1554	0.593	-0.547	1.732	5.970	2.878	6.64e-03	8.95e-02	-2.601	coproporphyrinogen-III oxidase	CPO
276	PF3D7_1303100	Pf3D7_13_v3	159024	+	892	-0.764	-1.043	-0.485	3.651	-2.879	6.62e-03	8.95e-02	-2.429	methyltransferase-like protein, putative	NA
334	PF3D7_1436500	Pf3D7_14_v3	1488706	+	1296	1.054	0.135	1.972	0.183	2.873	6.73e-03	8.95e-02	-2.335	GTP-binding protein, putative	NA
110	PF3D7_0703700	Pf3D7_07_v3	146645	-	750	0.495	-0.380	1.370	7.579	2.868	6.82e-03	8.98e-02	-2.733	conserved Plasmodium protein, unknown function	NA
171	PF3D7_0931400	Pf3D7_09_v3	1263347	+	1484	-0.845	-1.123	-0.567	3.547	-2.862	6.93e-03	9.00e-02	-2.430	conserved Plasmodium protein, unknown function	NA
206	PF3D7_1108600	Pf3D7_11_v3	369675	-	1032	-0.677	-1.052	-0.302	9.227	-2.866	6.92e-03	9.00e-02	-2.795	endoplasmic reticulum-resident calcium binding protein	ERC
306	PF3D7_1360100	Pf3D7_13_v3	2405249	-	969	-0.524	-0.778	-0.270	5.582	-2.864	6.88e-03	9.00e-02	-2.583	RNA-binding protein, putative	NA
329	PF3D7_1426000	Pf3D7_14_v3	1016133	-	486	0.490	0.116	0.864	8.627	2.863	6.90e-03	9.00e-02	-2.789	60S ribosomal protein L21	RPL21
15	PF3D7_0202500	Pf3D7_02_v3	127994	+	321	-0.663	-1.051	-0.275	12.139	-2.862	6.99e-03	9.04e-02	-2.822	early transcribed membrane protein 2	ETRAMP2
157	PF3D7_0903100	Pf3D7_09_v3	130140	-	798	0.695	0.070	1.319	4.700	2.858	7.00e-03	9.04e-02	-2.523	protein RER1, putative	RER1
21	PF3D7_0218700	Pf3D7_02_v3	763491	-	1701	-0.606	-1.170	-0.042	7.123	-2.852	7.11e-03	9.05e-02	-2.738	pre-mRNA-processing protein 45, putative	PRP45
150	PF3D7_0826100	Pf3D7_08_v3	1113369	-	25776	-0.526	-0.989	-0.064	10.275	-2.853	7.08e-03	9.05e-02	-2.840	E3 ubiquitin-protein ligase, putative	NA
192	PF3D7_1027300	Pf3D7_10_v3	1140589	-	2014	-0.763	-1.045	-0.481	8.469	-2.857	7.12e-03	9.05e-02	-2.799	peroxiredoxin	nPrx
250	PF3D7_1229600	Pf3D7_12_v3	1214043	-	3673	-1.015	-1.610	-0.421	1.452	-2.855	7.06e-03	9.05e-02	-2.378	conserved Plasmodium protein, unknown function	NA
266	PF3D7_1247400	Pf3D7_12_v3	1955124	-	915	-0.628	-1.393	0.137	6.237	-2.853	7.10e-03	9.05e-02	-2.676	peptidyl-prolyl cis-trans isomerase FKBP35	FKBP35
78	PF3D7_0528000	Pf3D7_05_v3	1156205	-	375	0.784	-1.169	2.738	3.675	2.849	7.17e-03	9.08e-02	-2.472	proteasome maturation factor UMP1, putative	UMP1
91	PF3D7_0612700	Pf3D7_06_v3	525987	-	1044	0.819	-0.189	1.826	1.993	2.847	7.20e-03	9.08e-02	-2.405	6-cysteine protein	P12
325	PF3D7_1417700	Pf3D7_14_v3	750330	+	1355	-0.593	-0.956	-0.231	4.828	-2.846	7.21e-03	9.08e-02	-2.565	conserved Plasmodium protein, unknown function	NA
49	PF3D7_0416000	Pf3D7_04_v3	701526	-	2637	-0.691	-1.273	-0.108	6.293	-2.845	7.24e-03	9.09e-02	-2.698	RNA-binding protein, putative	NA
26	PF3D7_0303400	Pf3D7_03_v3	178420	+	2708	1.000	0.628	1.372	1.354	2.833	7.46e-03	9.26e-02	-2.423	palmitoyltransferase DHHC1	DHHC1
158	PF3D7_0905300	Pf3D7_09_v3	251353	-	18357	-0.896	-1.244	-0.548	2.709	-2.834	7.44e-03	9.26e-02	-2.466	dynein heavy chain, putative	NA
208	PF3D7_1111000	Pf3D7_11_v3	434802	+	1740	0.564	-0.224	1.352	5.391	2.833	7.46e-03	9.26e-02	-2.644	tRNA m5C-methyltransferase, putative	NA
327	PF3D7_1423200	Pf3D7_14_v3	933059	+	2299	-0.588	-0.881	-0.294	5.853	-2.834	7.45e-03	9.26e-02	-2.693	peptidyl-prolyl cis-trans isomerase	CYP52
74	PF3D7_0523300	Pf3D7_05_v3	970266	-	697	1.001	0.197	1.805	0.700	2.826	7.59e-03	9.29e-02	-2.431	conserved Plasmodium protein, unknown function	NA
176	PF3D7_1002300	Pf3D7_10_v3	117242	+	1293	0.867	0.028	1.706	1.347	2.827	7.58e-03	9.29e-02	-2.437	conserved Plasmodium protein, unknown function	NA
290	PF3D7_1322100	Pf3D7_13_v3	920971	+	8479	-0.528	-1.188	0.132	9.385	-2.826	7.59e-03	9.29e-02	-2.884	histone-lysine N-methyltransferase SET2	SET2
294	PF3D7_1341100	Pf3D7_13_v3	1632602	-	108	-1.102	-1.788	-0.415	3.017	-2.826	7.60e-03	9.29e-02	-2.477	U6 spliceosomal RNA	NA
314	PF3D7_1373500	Pf3D7_13_v3	2884786	-	7555	-0.781	-1.245	-0.318	4.450	-2.826	7.60e-03	9.29e-02	-2.573	erythrocyte membrane protein 1, PfEMP1	VAR
245	PF3D7_1225200	Pf3D7_12_v3	1024455	-	3564	0.382	-0.352	1.116	6.893	2.824	7.64e-03	9.32e-02	-2.796	conserved Plasmodium protein, unknown function	NA
63	PF3D7_0506700	Pf3D7_05_v3	280886	+	2460	-0.562	-1.252	0.128	4.982	-2.815	7.81e-03	9.49e-02	-2.662	GTPase-activating protein, putative	NA
219	PF3D7_1126100	Pf3D7_11_v3	1018366	-	4130	0.858	0.339	1.377	1.600	2.811	7.90e-03	9.57e-02	-2.475	autophagy-related protein 7, putative	ATG7
88	PF3D7_0607000	Pf3D7_06_v3	293864	+	2934	-0.447	-1.635	0.742	10.481	-2.807	7.97e-03	9.61e-02	-2.949	translation initiation factor IF-2, putative	NA
94	PF3D7_0614200	Pf3D7_06_v3	593172	-	2733	0.813	-0.615	2.241	3.914	2.807	7.98e-03	9.61e-02	-2.582	cytosolic Fe-S cluster assembly factor NAR1, putative	NAR1
140	PF3D7_0808600	Pf3D7_08_v3	431165	+	7887	-0.842	-1.341	-0.344	4.353	-2.804	8.04e-03	9.66e-02	-2.623	erythrocyte membrane protein 1, PfEMP1	VAR
126	PF3D7_0717400	Pf3D7_07_v3	751877	+	2256	-0.411	-1.105	0.283	7.621	-2.802	8.08e-03	9.67e-02	-2.889	queuine tRNA-ribosyltransferase, putative	NA
332	PF3D7_1431600	Pf3D7_14_v3	1244018	+	1389	1.118	0.219	2.016	1.156	2.798	8.15e-03	9.74e-02	-2.493	succinyl-CoA ligase [ADP-forming] subunit beta, putative	NA
38	PF3D7_0400200	Pf3D7_04_v3	38955	+	1200	-1.094	-1.337	-0.852	2.992	-2.789	8.34e-03	9.86e-02	-2.562	erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene	NA
89	PF3D7_0608700	Pf3D7_06_v3	358391	+	1813	-0.362	-0.916	0.193	9.108	-2.789	8.35e-03	9.86e-02	-2.977	T-complex protein 1 subunit zeta	CCT6
344	PF3D7_1450300	Pf3D7_14_v3	2056641	+	2598	0.766	0.095	1.436	5.175	2.789	8.35e-03	9.86e-02	-2.742	NADPH–cytochrome P450 reductase, putative	CPR
351	PF3D7_1459300	Pf3D7_14_v3	2432177	+	570	0.803	0.428	1.178	1.803	2.789	8.35e-03	9.86e-02	-2.529	OPA3-like protein, putative	NA
320	PF3D7_1412700	Pf3D7_14_v3	512363	+	3660	-0.569	-1.258	0.119	5.935	-2.787	8.40e-03	9.89e-02	-2.800	AAA family ATPase, putative	NA
113	PF3D7_0707900	Pf3D7_07_v3	366929	+	780	-0.414	-1.143	0.315	7.553	-2.784	8.46e-03	9.90e-02	-2.928	ribosomal protein S8e, putative	NA
261	PF3D7_1244100	Pf3D7_12_v3	1847677	+	4480	-0.482	-0.753	-0.210	5.912	-2.781	8.53e-03	9.90e-02	-2.816	N-alpha-acetyltransferase 15, NatA auxiliary subunit, putative	NA
321	PF3D7_1414100	Pf3D7_14_v3	560093	+	2232	0.548	-0.272	1.368	6.992	2.781	8.51e-03	9.90e-02	-2.898	conserved Plasmodium protein, unknown function	NA
336	PF3D7_1439100	Pf3D7_14_v3	1580750	+	8108	-0.574	-0.972	-0.177	6.512	-2.782	8.50e-03	9.90e-02	-2.863	DEAD/DEAH box helicase, putative	NA
342	PF3D7_1447200	Pf3D7_14_v3	1933985	+	1791	-0.429	-0.856	-0.001	7.819	-2.781	8.52e-03	9.90e-02	-2.951	conserved Plasmodium protein, unknown function	NA
253	PF3D7_1232200	Pf3D7_12_v3	1333134	+	1763	-0.941	-1.961	0.079	0.865	-2.777	8.60e-03	9.95e-02	-2.534	dihydrolipoyl dehydrogenase, mitochondrial	LPD1

Heatmap of deregulated genes

col_annot <- data.frame(row.names = colnames(v$E), stringsAsFactors = F)
col_annot$phenotype[substring(colnames(v$E), 1, 1) == "I"] <- "non-severe"
col_annot$phenotype[substring(colnames(v$E), 1, 1) == "S"] <- "severe"
col_annot$phenotype <- as.factor(col_annot$phenotype)

pheatmap(v2$E[rownames(v$E) %in% top_ring_ruv$GeneID, ], show_rownames = FALSE, scale = "row", annotation_col = col_annot, annotation_colors = list(phenotype = c(`non-severe` = colors[1], 
    severe = colors[2])))

Gene set analysis

First GO set enrichment using limma’s mroast.

# genesets <- AnnotationDbi::select(org.Pf.plasmo.db, keys=top_ring_ruv$GeneID, keytype='ALIAS', columns = c('GO','PATH')) go.gene.sets <-
# lapply(split.data.frame(genesets,genesets$GO), function(x) as.vector(x$ALIAS)) kegg.gene.sets <- lapply(split.data.frame(genesets,genesets$PATH),
# function(x) as.vector(x$ALIAS))
MIN_SET_SIZE <- 3

go.gene.df <- fread("./data/go_gene_lists.txt", sep = "\t", data.table = FALSE)
go.gene.sets <- lapply(go.gene.df$Genes, function(x) {
    x <- unlist(str_split(x, ","))
    x <- x[x != ""]
})
names(go.gene.sets) <- go.gene.df$GO_ID
go.gene.sets <- go.gene.sets[unlist(lapply(go.gene.sets, length)) >= MIN_SET_SIZE]

kegg.gene.df <- fread("./data/kegg_gene_lists.txt", sep = "\t", data.table = FALSE)
kegg.gene.sets <- lapply(kegg.gene.df$Genes, function(x) {
    x <- unlist(str_split(x, ","))
    x <- x[x != ""]
})
names(kegg.gene.sets) <- kegg.gene.df$KEGG_ID
kegg.gene.sets <- kegg.gene.sets[unlist(lapply(kegg.gene.sets, length)) >= MIN_SET_SIZE]

indices <- ids2indices(go.gene.sets, rownames(v2), remove.empty = TRUE)
go_mr <- mroast(v2, index = indices, design = modRUV, contrast = 2, nrot = 10000, set.statistic = "floormean")
go_cam <- camera(v2, index = indices, design = modRUV, contrast = 2)

go_mr$PValue <- format(go_mr$PValue, scientific = TRUE, digits = 3)
go_mr$FDR <- format(go_mr$FDR, scientific = TRUE, digits = 3)
go_mr$PValue.Mixed <- format(go_mr$PValue.Mixed, scientific = TRUE, digits = 3)
go_mr$FDR.Mixed <- format(go_mr$FDR.Mixed, scientific = TRUE, digits = 3)
kable(go_mr, digits = 3)

	NGenes	PropDown	PropUp	Direction	PValue	FDR	PValue.Mixed	FDR.Mixed
GO:0016337	54	0.852	0.019	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0098602	54	0.852	0.019	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0007155	69	0.696	0.014	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0020035	93	0.634	0.032	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0044406	93	0.634	0.032	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0034118	87	0.632	0.011	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0020013	87	0.632	0.011	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0030155	87	0.632	0.011	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0034110	87	0.632	0.011	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0022407	87	0.632	0.011	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0044068	88	0.625	0.011	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0051807	93	0.624	0.022	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0051834	93	0.624	0.022	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0051832	93	0.624	0.022	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0043207	93	0.624	0.022	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0052564	93	0.624	0.022	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0051805	93	0.624	0.022	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0052173	93	0.624	0.022	Down	1.00e-04	1.46e-03	2.00e-04	3.08e-03
GO:0051809	92	0.620	0.022	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0020033	92	0.620	0.022	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0044003	89	0.618	0.011	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0051817	89	0.618	0.011	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0009607	94	0.617	0.021	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0035821	90	0.611	0.022	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0009605	100	0.610	0.030	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0022610	113	0.558	0.035	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0065008	149	0.456	0.107	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0044403	157	0.446	0.096	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0044419	157	0.446	0.096	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0051701	147	0.442	0.082	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0050896	291	0.357	0.096	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0065007	401	0.309	0.150	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0050794	359	0.309	0.142	Down	1.00e-04	1.46e-03	1.00e-04	1.34e-03
GO:0009405	84	0.690	0.048	Down	2.00e-04	4.02e-03	2.00e-04	3.08e-03
GO:0051704	189	0.444	0.095	Down	2.00e-04	4.02e-03	2.00e-04	3.08e-03
GO:0050789	380	0.321	0.139	Down	2.00e-04	4.02e-03	1.00e-04	1.34e-03
GO:0051707	93	0.624	0.022	Down	3.00e-04	6.34e-03	2.00e-04	3.08e-03
GO:0009396	4	0.500	0.000	Down	3.00e-04	6.34e-03	1.60e-03	8.44e-03
GO:0016579	11	0.545	0.182	Down	4.00e-04	8.43e-03	7.00e-04	5.91e-03
GO:0006848	2	0.500	0.000	Down	4.00e-04	8.43e-03	6.00e-04	5.76e-03
GO:0000245	9	0.667	0.111	Down	5.00e-04	1.01e-02	2.00e-04	3.08e-03
GO:0070646	11	0.545	0.182	Down	5.00e-04	1.01e-02	6.00e-04	5.76e-03
GO:0006760	5	0.400	0.200	Down	5.00e-04	1.01e-02	5.00e-04	5.63e-03
GO:0031123	8	0.125	0.750	Up	6.00e-04	1.20e-02	9.00e-04	6.35e-03
GO:0016485	10	0.500	0.000	Down	7.00e-04	1.39e-02	1.80e-03	8.79e-03
GO:0031167	2	1.000	0.000	Down	8.00e-04	1.57e-02	8.00e-04	6.08e-03
GO:0042026	3	0.667	0.000	Down	9.00e-04	1.71e-02	1.40e-03	7.93e-03
GO:0051604	12	0.417	0.000	Down	9.00e-04	1.71e-02	4.00e-03	1.30e-02
GO:0008154	1	1.000	0.000	Down	1.00e-03	1.73e-02	1.00e-03	6.73e-03
GO:0006206	6	0.500	0.000	Down	1.00e-03	1.73e-02	4.40e-03	1.37e-02
GO:0009112	7	0.429	0.000	Down	1.00e-03	1.73e-02	5.10e-03	1.49e-02
GO:0019220	27	0.222	0.407	Up	1.00e-03	1.73e-02	1.00e-04	1.34e-03
GO:0006950	91	0.286	0.165	Down	1.00e-03	1.73e-02	4.00e-04	5.11e-03
GO:0006207	5	0.400	0.000	Down	1.30e-03	2.23e-02	1.20e-02	2.58e-02
GO:0046112	5	0.400	0.000	Down	1.50e-03	2.45e-02	1.32e-02	2.77e-02
GO:0048519	16	0.312	0.375	Down	1.50e-03	2.45e-02	3.00e-04	4.38e-03
GO:0044699	809	0.235	0.178	Down	1.50e-03	2.45e-02	5.00e-04	5.63e-03
GO:0006457	72	0.417	0.097	Down	1.60e-03	2.53e-02	6.00e-04	5.76e-03
GO:0019856	5	0.400	0.000	Down	1.60e-03	2.53e-02	1.44e-02	2.91e-02
GO:0007007	3	0.667	0.000	Down	1.80e-03	2.72e-02	5.50e-03	1.53e-02
GO:0090151	3	0.667	0.000	Down	1.80e-03	2.72e-02	5.70e-03	1.55e-02
GO:0071840	251	0.283	0.151	Down	1.80e-03	2.72e-02	1.20e-03	7.25e-03
GO:0045039	3	0.667	0.000	Down	1.90e-03	2.79e-02	6.00e-03	1.60e-02
GO:0051174	27	0.222	0.407	Up	1.90e-03	2.79e-02	5.00e-04	5.63e-03
GO:0042325	5	0.000	0.800	Up	2.00e-03	2.85e-02	9.70e-03	2.20e-02
GO:0043631	6	0.167	0.667	Up	2.00e-03	2.85e-02	2.00e-03	9.12e-03
GO:0007006	3	0.667	0.000	Down	2.10e-03	2.95e-02	5.20e-03	1.50e-02
GO:0006518	11	0.364	0.182	Down	2.20e-03	3.00e-02	2.80e-03	1.07e-02
GO:0009260	18	0.111	0.333	Up	2.20e-03	3.00e-02	1.90e-03	9.01e-03
GO:0001817	3	0.667	0.000	Down	2.40e-03	3.15e-02	2.40e-03	9.98e-03
GO:0006730	4	0.500	0.250	Down	2.40e-03	3.15e-02	6.00e-04	5.76e-03
GO:0006575	13	0.308	0.308	Down	2.40e-03	3.15e-02	8.00e-04	6.08e-03
GO:0016568	18	0.389	0.167	Down	2.50e-03	3.24e-02	1.20e-03	7.25e-03
GO:0016571	5	0.600	0.000	Down	2.70e-03	3.44e-02	2.50e-03	1.02e-02
GO:0001932	5	0.000	0.800	Up	2.80e-03	3.44e-02	9.80e-03	2.22e-02
GO:0031399	5	0.000	0.800	Up	2.80e-03	3.44e-02	1.03e-02	2.27e-02
GO:0002098	4	0.000	0.500	Up	2.80e-03	3.44e-02	1.13e-02	2.45e-02
GO:0008033	37	0.108	0.351	Up	2.90e-03	3.48e-02	1.10e-03	7.13e-03
GO:0015914	4	0.250	0.250	Down	2.90e-03	3.48e-02	1.00e-04	1.34e-03
GO:0042221	68	0.250	0.088	Down	3.00e-03	3.55e-02	1.60e-03	8.44e-03
GO:0009152	17	0.118	0.353	Up	3.10e-03	3.63e-02	1.70e-03	8.55e-03
GO:0044085	153	0.301	0.150	Down	3.20e-03	3.67e-02	1.00e-03	6.73e-03
GO:0051239	3	0.667	0.000	Down	3.30e-03	3.67e-02	3.30e-03	1.17e-02
GO:0009201	8	0.125	0.625	Up	3.40e-03	3.67e-02	2.30e-03	9.98e-03
GO:1902580	33	0.273	0.061	Down	3.40e-03	3.67e-02	7.30e-03	1.80e-02
GO:1901137	55	0.145	0.327	Up	3.50e-03	3.67e-02	8.00e-04	6.08e-03
GO:0009206	8	0.125	0.625	Up	3.60e-03	3.67e-02	2.40e-03	9.98e-03
GO:0006378	5	0.200	0.600	Up	3.70e-03	3.67e-02	2.60e-03	1.05e-02
GO:0050790	27	0.259	0.370	Up	3.70e-03	3.67e-02	7.00e-04	5.91e-03
GO:0006325	29	0.345	0.172	Down	3.70e-03	3.67e-02	1.40e-03	7.93e-03
GO:0006281	50	0.160	0.220	Up	3.70e-03	3.67e-02	2.90e-03	1.09e-02
GO:0033554	55	0.200	0.200	Up	3.80e-03	3.67e-02	1.90e-03	9.01e-03
GO:0009628	22	0.500	0.091	Down	3.90e-03	3.67e-02	1.90e-03	9.01e-03
GO:0043603	15	0.267	0.133	Down	3.90e-03	3.67e-02	1.37e-02	2.82e-02
GO:0006996	110	0.264	0.145	Down	3.90e-03	3.67e-02	2.00e-03	9.12e-03
GO:0034641	602	0.236	0.199	Down	3.90e-03	3.67e-02	5.00e-04	5.63e-03
GO:0044260	985	0.236	0.196	Down	3.90e-03	3.67e-02	6.00e-04	5.76e-03
GO:0070585	14	0.500	0.071	Down	4.00e-03	3.67e-02	3.70e-03	1.25e-02
GO:0007005	14	0.500	0.071	Down	4.00e-03	3.67e-02	4.10e-03	1.31e-02
GO:0071806	16	0.312	0.062	Down	4.00e-03	3.67e-02	7.60e-03	1.86e-02
GO:0006396	207	0.295	0.242	Down	4.10e-03	3.67e-02	4.00e-04	5.11e-03
GO:0009987	1474	0.224	0.190	Down	4.10e-03	3.67e-02	6.00e-04	5.76e-03
GO:0072594	32	0.281	0.062	Down	4.20e-03	3.67e-02	7.20e-03	1.79e-02
GO:0044238	1268	0.226	0.189	Down	4.20e-03	3.67e-02	5.00e-04	5.63e-03
GO:0043414	18	0.278	0.278	Down	4.30e-03	3.67e-02	7.00e-04	5.91e-03
GO:0016043	183	0.273	0.148	Down	4.30e-03	3.67e-02	1.30e-03	7.67e-03
GO:0016070	365	0.266	0.227	Down	4.30e-03	3.67e-02	7.00e-04	5.91e-03
GO:0008380	81	0.407	0.173	Down	4.40e-03	3.67e-02	8.00e-04	6.08e-03
GO:0042559	6	0.333	0.333	Down	4.40e-03	3.67e-02	1.50e-03	8.22e-03
GO:0006725	583	0.233	0.201	Down	4.40e-03	3.67e-02	5.00e-04	5.63e-03
GO:0046483	584	0.233	0.202	Down	4.40e-03	3.67e-02	4.00e-04	5.11e-03
GO:0031124	5	0.200	0.600	Up	4.50e-03	3.67e-02	2.70e-03	1.05e-02
GO:1901360	587	0.232	0.201	Down	4.50e-03	3.67e-02	2.00e-04	3.08e-03
GO:0006807	627	0.230	0.203	Down	4.50e-03	3.67e-02	6.00e-04	5.76e-03
GO:0043933	107	0.290	0.140	Down	4.60e-03	3.67e-02	8.00e-04	6.08e-03
GO:0010467	524	0.258	0.200	Down	4.60e-03	3.67e-02	4.00e-04	5.11e-03
GO:0043170	1043	0.232	0.196	Down	4.60e-03	3.67e-02	6.00e-04	5.76e-03
GO:0009266	21	0.476	0.095	Down	4.70e-03	3.67e-02	1.90e-03	9.01e-03
GO:0065009	27	0.259	0.370	Up	4.70e-03	3.67e-02	9.00e-04	6.35e-03
GO:0046390	19	0.105	0.316	Up	4.70e-03	3.67e-02	5.20e-03	1.50e-02
GO:0006139	560	0.238	0.196	Down	4.70e-03	3.67e-02	3.00e-04	4.38e-03
GO:0006094	5	0.800	0.000	Down	4.80e-03	3.67e-02	5.10e-03	1.49e-02
GO:0042398	11	0.273	0.273	Down	4.80e-03	3.67e-02	2.30e-03	9.98e-03
GO:0051276	43	0.326	0.140	Down	4.90e-03	3.67e-02	4.60e-03	1.41e-02
GO:0033365	33	0.273	0.091	Down	4.90e-03	3.67e-02	6.60e-03	1.70e-02
GO:0072655	14	0.500	0.071	Down	5.00e-03	3.67e-02	5.30e-03	1.52e-02
GO:0006626	14	0.500	0.071	Down	5.00e-03	3.67e-02	5.40e-03	1.52e-02
GO:0072657	11	0.273	0.091	Down	5.00e-03	3.67e-02	5.30e-03	1.52e-02
GO:0090304	471	0.246	0.210	Down	5.00e-03	3.67e-02	7.00e-04	5.91e-03
GO:0006974	51	0.176	0.216	Up	5.00e-03	3.67e-02	4.10e-03	1.31e-02
GO:0045454	29	0.345	0.207	Down	5.10e-03	3.72e-02	3.00e-04	4.38e-03
GO:0002097	4	0.000	0.500	Up	5.20e-03	3.76e-02	1.11e-02	2.42e-02
GO:0046364	6	0.667	0.000	Down	5.30e-03	3.79e-02	6.80e-03	1.74e-02
GO:0016255	4	0.000	1.000	Up	5.40e-03	3.79e-02	6.30e-03	1.66e-02
GO:0019319	6	0.667	0.000	Down	5.40e-03	3.79e-02	6.40e-03	1.67e-02
GO:0006605	34	0.265	0.059	Down	5.40e-03	3.79e-02	9.30e-03	2.14e-02
GO:0031338	14	0.000	0.357	Up	5.50e-03	3.83e-02	3.40e-03	1.20e-02
GO:0071704	1299	0.221	0.193	Down	5.60e-03	3.86e-02	6.00e-04	5.76e-03
GO:0051188	30	0.067	0.333	Up	5.70e-03	3.86e-02	2.50e-03	1.02e-02
GO:0006520	75	0.280	0.200	Down	5.70e-03	3.86e-02	1.30e-03	7.67e-03
GO:0090150	11	0.273	0.091	Down	5.70e-03	3.86e-02	6.00e-03	1.60e-02
GO:0009408	20	0.450	0.100	Down	5.80e-03	3.86e-02	1.70e-03	8.55e-03
GO:0019222	152	0.243	0.184	Down	5.80e-03	3.86e-02	2.70e-03	1.05e-02
GO:0006813	4	0.000	0.500	Up	5.90e-03	3.86e-02	1.87e-02	3.57e-02
GO:0008213	8	0.375	0.250	Down	5.90e-03	3.86e-02	1.50e-03	8.22e-03
GO:0016071	100	0.310	0.240	Down	5.90e-03	3.86e-02	7.00e-04	5.91e-03
GO:0035966	12	0.417	0.083	Down	6.00e-03	3.87e-02	2.70e-03	1.05e-02
GO:0008152	1383	0.221	0.195	Down	6.00e-03	3.87e-02	6.00e-04	5.76e-03
GO:0006479	8	0.375	0.250	Down	6.10e-03	3.87e-02	1.70e-03	8.55e-03
GO:0033124	18	0.222	0.333	Up	6.10e-03	3.87e-02	8.00e-04	6.08e-03
GO:0032012	3	0.333	0.667	Up	6.20e-03	3.87e-02	1.20e-03	7.25e-03
GO:0006164	19	0.105	0.316	Up	6.20e-03	3.87e-02	1.90e-03	9.01e-03
GO:0044237	1238	0.226	0.193	Down	6.20e-03	3.87e-02	9.00e-04	6.35e-03
GO:0010608	25	0.360	0.080	Down	6.30e-03	3.91e-02	4.70e-03	1.42e-02
GO:0032312	2	0.000	1.000	Up	6.40e-03	3.92e-02	6.40e-03	1.67e-02
GO:0032259	26	0.269	0.231	Down	6.40e-03	3.92e-02	2.00e-04	3.08e-03
GO:0009145	9	0.222	0.556	Up	6.50e-03	3.96e-02	4.00e-04	5.11e-03
GO:0043087	18	0.222	0.333	Up	6.60e-03	4.00e-02	1.20e-03	7.25e-03
GO:0051051	3	0.000	1.000	Up	6.80e-03	4.04e-02	7.30e-03	1.80e-02
GO:0006271	5	0.000	0.600	Up	6.80e-03	4.04e-02	1.73e-02	3.34e-02
GO:0042493	51	0.235	0.078	Down	6.80e-03	4.04e-02	2.40e-03	9.98e-03
GO:0006265	3	0.667	0.333	Down	7.00e-03	4.14e-02	1.60e-03	8.44e-03
GO:0000154	5	0.600	0.000	Down	7.30e-03	4.24e-02	4.40e-03	1.37e-02
GO:0019752	129	0.279	0.178	Down	7.30e-03	4.24e-02	2.50e-03	1.02e-02
GO:0009894	22	0.364	0.273	Down	7.40e-03	4.24e-02	8.00e-04	6.08e-03
GO:1901564	179	0.246	0.201	Down	7.40e-03	4.24e-02	9.00e-04	6.35e-03
GO:0019538	628	0.231	0.182	Down	7.40e-03	4.24e-02	8.00e-04	6.08e-03
GO:0030029	10	0.300	0.200	Down	7.50e-03	4.27e-02	4.30e-03	1.36e-02
GO:0006986	12	0.417	0.083	Down	7.60e-03	4.28e-02	3.20e-03	1.16e-02
GO:0000377	59	0.407	0.186	Down	7.60e-03	4.28e-02	6.00e-04	5.76e-03
GO:0042451	17	0.176	0.353	Up	7.70e-03	4.31e-02	1.20e-03	7.25e-03
GO:0010033	13	0.385	0.077	Down	7.80e-03	4.32e-02	3.40e-03	1.20e-02
GO:0043436	130	0.277	0.177	Down	7.80e-03	4.32e-02	2.00e-03	9.12e-03
GO:0044724	24	0.583	0.042	Down	7.90e-03	4.32e-02	7.70e-03	1.87e-02
GO:0000375	64	0.422	0.172	Down	7.90e-03	4.32e-02	1.10e-03	7.13e-03
GO:0000398	59	0.407	0.186	Down	8.10e-03	4.38e-02	8.00e-04	6.08e-03
GO:0006397	93	0.323	0.258	Down	8.10e-03	4.38e-02	9.00e-04	6.35e-03
GO:0034968	4	0.500	0.000	Down	8.20e-03	4.39e-02	6.50e-03	1.68e-02
GO:0080090	141	0.234	0.184	Down	8.20e-03	4.39e-02	2.40e-03	9.98e-03
GO:0000079	3	0.000	1.000	Up	8.30e-03	4.39e-02	8.60e-03	2.02e-02
GO:0046129	17	0.176	0.353	Up	8.30e-03	4.39e-02	1.20e-03	7.25e-03
GO:0006096	17	0.647	0.059	Down	8.40e-03	4.42e-02	7.60e-03	1.86e-02
GO:0009247	12	0.083	0.583	Up	8.60e-03	4.45e-02	1.01e-02	2.26e-02
GO:0051336	21	0.286	0.333	Up	8.60e-03	4.45e-02	2.00e-04	3.08e-03
GO:0030036	8	0.250	0.250	Down	8.60e-03	4.45e-02	5.10e-03	1.49e-02
GO:0006338	4	0.500	0.000	Down	8.70e-03	4.46e-02	1.33e-02	2.77e-02
GO:0006140	19	0.263	0.316	Up	8.70e-03	4.46e-02	7.00e-04	5.91e-03
GO:0016052	24	0.583	0.042	Down	8.80e-03	4.46e-02	9.40e-03	2.15e-02
GO:0000910	4	0.000	0.500	Up	8.80e-03	4.46e-02	1.90e-02	3.60e-02
GO:0006081	6	0.167	0.333	Up	8.90e-03	4.49e-02	6.40e-03	1.67e-02
GO:0016051	12	0.500	0.000	Down	9.00e-03	4.50e-02	7.80e-03	1.89e-02
GO:0030811	19	0.263	0.316	Up	9.10e-03	4.50e-02	1.10e-03	7.13e-03
GO:0006790	20	0.100	0.300	Up	9.10e-03	4.50e-02	9.50e-03	2.17e-02
GO:0033121	19	0.263	0.316	Up	9.20e-03	4.50e-02	9.00e-04	6.35e-03
GO:0034660	124	0.266	0.234	Down	9.20e-03	4.50e-02	8.00e-04	6.08e-03
GO:0043412	249	0.157	0.225	Up	9.20e-03	4.50e-02	1.20e-03	7.25e-03
GO:0006475	4	0.000	0.750	Up	9.30e-03	4.50e-02	3.31e-02	5.28e-02
GO:0009118	19	0.263	0.316	Up	9.30e-03	4.50e-02	5.00e-04	5.63e-03
GO:0022616	5	0.000	0.600	Up	9.40e-03	4.53e-02	2.12e-02	3.86e-02
GO:0051651	2	0.000	1.000	Up	9.60e-03	4.55e-02	9.70e-03	2.20e-02
GO:0006082	130	0.277	0.177	Down	9.60e-03	4.55e-02	2.70e-03	1.05e-02
GO:1900542	19	0.263	0.316	Up	9.80e-03	4.55e-02	6.00e-04	5.76e-03
GO:1901607	11	0.182	0.091	Down	9.80e-03	4.55e-02	2.06e-02	3.77e-02
GO:0018393	4	0.000	0.750	Up	9.90e-03	4.55e-02	3.28e-02	5.26e-02
GO:0009452	6	0.333	0.167	Down	9.90e-03	4.55e-02	2.20e-03	9.78e-03
GO:0022613	98	0.327	0.143	Down	9.90e-03	4.55e-02	2.40e-03	9.98e-03
GO:0071900	3	0.000	1.000	Up	1.00e-02	4.55e-02	1.01e-02	2.26e-02
GO:0006379	4	0.250	0.750	Up	1.00e-02	4.55e-02	7.30e-03	1.80e-02
GO:0046467	13	0.077	0.615	Up	1.00e-02	4.55e-02	1.01e-02	2.26e-02
GO:0006465	7	0.429	0.000	Down	1.00e-02	4.55e-02	2.42e-02	4.28e-02
GO:0009108	24	0.083	0.292	Up	1.00e-02	4.55e-02	1.70e-03	8.55e-03
GO:0016573	4	0.000	0.750	Up	1.01e-02	4.57e-02	3.26e-02	5.26e-02
GO:0044743	6	0.667	0.000	Down	1.02e-02	4.57e-02	8.70e-03	2.04e-02
GO:0042558	7	0.286	0.429	Down	1.02e-02	4.57e-02	1.30e-03	7.67e-03
GO:0010468	116	0.224	0.147	Down	1.03e-02	4.60e-02	5.70e-03	1.55e-02
GO:0048523	10	0.300	0.200	Down	1.04e-02	4.60e-02	7.50e-03	1.84e-02
GO:0006754	7	0.143	0.571	Up	1.05e-02	4.60e-02	7.00e-03	1.77e-02
GO:0034622	64	0.328	0.141	Down	1.05e-02	4.60e-02	3.10e-03	1.14e-02
GO:0031329	19	0.263	0.316	Up	1.05e-02	4.60e-02	9.00e-04	6.35e-03
GO:0006410	5	0.000	0.600	Up	1.06e-02	4.60e-02	2.09e-02	3.81e-02
GO:0044712	59	0.339	0.136	Down	1.06e-02	4.60e-02	3.70e-03	1.25e-02
GO:0006399	78	0.231	0.269	Up	1.07e-02	4.62e-02	1.60e-03	8.44e-03
GO:0032507	2	0.000	1.000	Up	1.08e-02	4.63e-02	1.12e-02	2.43e-02
GO:0036260	6	0.333	0.167	Down	1.09e-02	4.63e-02	2.00e-03	9.12e-03
GO:0008616	4	0.500	0.250	Down	1.10e-02	4.63e-02	4.70e-03	1.42e-02
GO:0046116	4	0.500	0.250	Down	1.10e-02	4.63e-02	5.80e-03	1.57e-02
GO:0033043	19	0.053	0.316	Up	1.10e-02	4.63e-02	3.80e-03	1.26e-02
GO:0060255	128	0.234	0.164	Down	1.10e-02	4.63e-02	4.00e-03	1.30e-02
GO:0006090	24	0.458	0.167	Down	1.11e-02	4.65e-02	4.50e-03	1.40e-02
GO:0018394	4	0.000	0.750	Up	1.13e-02	4.65e-02	3.33e-02	5.29e-02
GO:0006006	12	0.583	0.000	Down	1.13e-02	4.65e-02	1.26e-02	2.66e-02
GO:0006289	11	0.182	0.364	Up	1.13e-02	4.65e-02	9.00e-04	6.35e-03
GO:0044267	562	0.237	0.181	Down	1.13e-02	4.65e-02	1.60e-03	8.44e-03
GO:0010629	6	0.500	0.167	Down	1.14e-02	4.68e-02	2.90e-03	1.09e-02
GO:0042158	18	0.000	0.556	Up	1.17e-02	4.78e-02	1.35e-02	2.79e-02
GO:0043241	6	0.000	0.500	Up	1.18e-02	4.80e-02	6.18e-02	8.30e-02
GO:0044271	158	0.196	0.215	Up	1.21e-02	4.90e-02	4.00e-04	5.11e-03
GO:0042176	3	1.000	0.000	Down	1.22e-02	4.90e-02	1.22e-02	2.61e-02
GO:0065003	74	0.297	0.135	Down	1.22e-02	4.90e-02	2.40e-03	9.98e-03
GO:0016072	48	0.312	0.188	Down	1.23e-02	4.90e-02	1.70e-03	8.55e-03
GO:0006497	18	0.000	0.556	Up	1.24e-02	4.90e-02	1.34e-02	2.78e-02
GO:0042157	18	0.000	0.556	Up	1.25e-02	4.90e-02	1.34e-02	2.78e-02
GO:0045017	17	0.059	0.471	Up	1.25e-02	4.90e-02	6.90e-03	1.76e-02
GO:0043543	15	0.000	0.467	Up	1.25e-02	4.90e-02	3.38e-02	5.33e-02
GO:0045859	4	0.000	0.750	Up	1.26e-02	4.90e-02	2.04e-02	3.74e-02
GO:0051186	45	0.156	0.267	Up	1.26e-02	4.90e-02	8.00e-04	6.08e-03
GO:0043549	4	0.000	0.750	Up	1.27e-02	4.90e-02	1.91e-02	3.61e-02
GO:0022607	83	0.289	0.145	Down	1.27e-02	4.90e-02	2.00e-03	9.12e-03
GO:0006413	48	0.208	0.167	Down	1.27e-02	4.90e-02	7.20e-03	1.79e-02
GO:0031323	139	0.216	0.194	Down	1.28e-02	4.90e-02	2.30e-03	9.98e-03
GO:0006664	13	0.077	0.538	Up	1.29e-02	4.90e-02	1.52e-02	3.03e-02
GO:0035383	7	0.000	0.429	Up	1.29e-02	4.90e-02	1.67e-02	3.24e-02
GO:0009892	8	0.375	0.250	Down	1.29e-02	4.90e-02	1.50e-03	8.22e-03
GO:0043648	10	0.300	0.000	Down	1.30e-02	4.91e-02	3.77e-02	5.73e-02
GO:0006259	120	0.175	0.192	Up	1.33e-02	4.99e-02	1.20e-03	7.25e-03
GO:0090305	10	0.200	0.500	Up	1.34e-02	4.99e-02	3.90e-03	1.28e-02
GO:0007275	6	0.000	0.333	Up	1.34e-02	4.99e-02	1.59e-02	3.15e-02
GO:0007018	19	0.263	0.211	Down	1.34e-02	4.99e-02	8.00e-04	6.08e-03
GO:0015985	7	0.143	0.571	Up	1.35e-02	4.99e-02	9.10e-03	2.11e-02
GO:0006364	48	0.312	0.188	Down	1.35e-02	4.99e-02	2.00e-03	9.12e-03
GO:0015986	7	0.143	0.571	Up	1.37e-02	5.02e-02	9.30e-03	2.14e-02
GO:0065002	11	0.364	0.000	Down	1.37e-02	5.02e-02	2.01e-02	3.72e-02
GO:0019725	42	0.262	0.238	Up	1.41e-02	5.15e-02	5.00e-04	5.63e-03
GO:0006417	22	0.318	0.091	Down	1.42e-02	5.16e-02	8.20e-03	1.95e-02
GO:0044092	3	0.667	0.333	Down	1.43e-02	5.16e-02	1.00e-03	6.73e-03
GO:0043086	3	0.667	0.333	Down	1.44e-02	5.16e-02	1.20e-03	7.25e-03
GO:0071826	31	0.323	0.097	Down	1.44e-02	5.16e-02	1.39e-02	2.85e-02
GO:0044707	7	0.000	0.286	Up	1.44e-02	5.16e-02	2.56e-02	4.48e-02
GO:0006875	4	0.250	0.750	Up	1.45e-02	5.18e-02	1.90e-03	9.01e-03
GO:0019318	14	0.500	0.000	Down	1.48e-02	5.25e-02	1.91e-02	3.61e-02
GO:0032318	15	0.200	0.333	Up	1.48e-02	5.25e-02	2.40e-03	9.98e-03
GO:0051338	4	0.000	0.750	Up	1.50e-02	5.26e-02	1.98e-02	3.68e-02
GO:0090501	4	0.250	0.500	Down	1.50e-02	5.26e-02	1.60e-03	8.44e-03
GO:0006839	18	0.389	0.056	Down	1.50e-02	5.26e-02	1.49e-02	2.99e-02
GO:0006643	15	0.067	0.600	Up	1.51e-02	5.28e-02	1.41e-02	2.86e-02
GO:0051246	31	0.355	0.194	Down	1.52e-02	5.29e-02	4.30e-03	1.36e-02
GO:1902531	17	0.294	0.294	Down	1.53e-02	5.31e-02	6.00e-04	5.76e-03
GO:0044763	585	0.200	0.191	Up	1.55e-02	5.36e-02	5.00e-04	5.63e-03
GO:0042455	22	0.227	0.318	Up	1.56e-02	5.36e-02	4.00e-04	5.11e-03
GO:0006066	7	0.286	0.000	Down	1.58e-02	5.36e-02	4.48e-02	6.35e-02
GO:0046474	16	0.062	0.500	Up	1.59e-02	5.36e-02	8.30e-03	1.97e-02
GO:0010605	7	0.429	0.286	Down	1.59e-02	5.36e-02	1.20e-03	7.25e-03
GO:1901605	24	0.167	0.167	Down	1.59e-02	5.36e-02	6.00e-03	1.60e-02
GO:0006637	7	0.000	0.429	Up	1.60e-02	5.36e-02	1.80e-02	3.46e-02
GO:0034654	128	0.211	0.188	Down	1.60e-02	5.36e-02	1.00e-03	6.73e-03
GO:0018130	152	0.204	0.204	Down	1.60e-02	5.36e-02	7.00e-04	5.91e-03
GO:0051716	109	0.174	0.156	Up	1.60e-02	5.36e-02	2.30e-03	9.98e-03
GO:0006732	37	0.189	0.243	Up	1.62e-02	5.41e-02	5.00e-04	5.63e-03
GO:0006812	42	0.214	0.262	Up	1.64e-02	5.41e-02	9.00e-04	6.35e-03
GO:0007049	36	0.083	0.167	Up	1.64e-02	5.41e-02	2.02e-02	3.73e-02
GO:0006506	9	0.000	0.667	Up	1.65e-02	5.41e-02	1.63e-02	3.20e-02
GO:0005996	14	0.500	0.000	Down	1.66e-02	5.41e-02	1.92e-02	3.62e-02
GO:0044272	14	0.071	0.357	Up	1.66e-02	5.41e-02	2.18e-02	3.95e-02
GO:0046578	17	0.294	0.294	Down	1.66e-02	5.41e-02	3.00e-04	4.38e-03
GO:0044767	11	0.000	0.273	Up	1.66e-02	5.41e-02	1.94e-02	3.64e-02
GO:0044723	42	0.429	0.071	Down	1.68e-02	5.43e-02	7.90e-03	1.91e-02
GO:0009142	10	0.200	0.500	Up	1.69e-02	5.43e-02	2.40e-03	9.98e-03
GO:0032501	8	0.000	0.250	Up	1.69e-02	5.43e-02	4.02e-02	5.97e-02
GO:0048518	11	0.364	0.091	Down	1.70e-02	5.43e-02	1.00e-02	2.25e-02
GO:0009163	22	0.227	0.318	Up	1.70e-02	5.43e-02	4.00e-04	5.11e-03
GO:0070647	29	0.310	0.172	Down	1.70e-02	5.43e-02	2.10e-03	9.45e-03
GO:0071976	4	0.000	0.250	Up	1.72e-02	5.47e-02	5.74e-02	7.76e-02
GO:0006897	7	0.286	0.143	Down	1.73e-02	5.47e-02	3.60e-03	1.24e-02
GO:0009451	43	0.140	0.233	Up	1.73e-02	5.47e-02	7.00e-04	5.91e-03
GO:0055065	4	0.250	0.750	Up	1.74e-02	5.47e-02	1.70e-03	8.55e-03
GO:0009889	111	0.207	0.153	Down	1.74e-02	5.47e-02	5.50e-03	1.53e-02
GO:0044281	231	0.242	0.169	Down	1.75e-02	5.48e-02	1.80e-03	8.79e-03
GO:0009058	529	0.189	0.208	Up	1.77e-02	5.52e-02	1.20e-03	7.25e-03
GO:0051056	17	0.294	0.294	Down	1.78e-02	5.54e-02	7.00e-04	5.91e-03
GO:0046148	6	0.000	0.500	Up	1.81e-02	5.59e-02	4.96e-02	6.91e-02
GO:0044249	516	0.186	0.205	Up	1.81e-02	5.59e-02	1.30e-03	7.67e-03
GO:0031326	111	0.207	0.153	Down	1.82e-02	5.59e-02	6.50e-03	1.68e-02
GO:1901362	155	0.200	0.200	Down	1.82e-02	5.59e-02	4.00e-04	5.11e-03
GO:0006779	6	0.000	0.500	Up	1.84e-02	5.63e-02	4.70e-02	6.62e-02
GO:0016042	5	0.200	0.400	Up	1.86e-02	5.65e-02	8.00e-04	6.08e-03
GO:0032879	27	0.111	0.333	Up	1.86e-02	5.65e-02	2.00e-03	9.12e-03
GO:0030001	16	0.188	0.312	Up	1.87e-02	5.65e-02	4.30e-03	1.36e-02
GO:0045892	4	0.500	0.000	Down	1.88e-02	5.65e-02	2.88e-02	4.84e-02
GO:0005975	53	0.377	0.094	Down	1.88e-02	5.65e-02	6.40e-03	1.67e-02
GO:0072522	22	0.182	0.273	Up	1.88e-02	5.65e-02	1.70e-03	8.55e-03
GO:0000350	3	0.667	0.333	Down	1.89e-02	5.66e-02	7.70e-03	1.87e-02
GO:0006351	81	0.210	0.185	Down	1.92e-02	5.73e-02	1.80e-03	8.79e-03
GO:2000112	110	0.209	0.155	Down	1.93e-02	5.74e-02	7.10e-03	1.79e-02
GO:0051172	4	0.500	0.000	Down	1.94e-02	5.74e-02	2.68e-02	4.65e-02
GO:0051049	27	0.111	0.333	Up	1.94e-02	5.74e-02	1.40e-03	7.93e-03
GO:0032502	12	0.000	0.250	Up	1.95e-02	5.75e-02	2.43e-02	4.29e-02
GO:0051128	22	0.091	0.273	Up	1.96e-02	5.75e-02	2.10e-03	9.45e-03
GO:0019438	148	0.203	0.203	Up	1.96e-02	5.75e-02	7.00e-04	5.91e-03
GO:0044802	14	0.214	0.143	Down	1.97e-02	5.76e-02	4.90e-03	1.46e-02
GO:0033014	6	0.000	0.500	Up	1.99e-02	5.76e-02	5.12e-02	7.08e-02
GO:0009056	171	0.304	0.140	Down	1.99e-02	5.76e-02	3.00e-03	1.12e-02
GO:0006783	6	0.000	0.500	Up	2.00e-02	5.76e-02	4.84e-02	6.77e-02
GO:0045934	4	0.500	0.000	Down	2.00e-02	5.76e-02	2.77e-02	4.73e-02
GO:0010556	110	0.209	0.155	Down	2.00e-02	5.76e-02	5.50e-03	1.53e-02
GO:1901659	23	0.217	0.304	Up	2.02e-02	5.80e-02	3.00e-04	4.38e-03
GO:2000113	4	0.500	0.000	Down	2.05e-02	5.85e-02	2.85e-02	4.82e-02
GO:0001510	9	0.222	0.333	Up	2.05e-02	5.85e-02	2.00e-04	3.08e-03
GO:0051253	4	0.500	0.000	Down	2.06e-02	5.86e-02	2.60e-02	4.54e-02
GO:0032784	3	0.667	0.000	Down	2.07e-02	5.87e-02	2.33e-02	4.15e-02
GO:1902679	4	0.500	0.000	Down	2.08e-02	5.88e-02	2.81e-02	4.77e-02
GO:0048583	27	0.259	0.222	Down	2.09e-02	5.89e-02	5.00e-04	5.63e-03
GO:0045185	3	0.000	0.667	Up	2.10e-02	5.89e-02	1.64e-02	3.21e-02
GO:0061024	17	0.235	0.118	Down	2.10e-02	5.89e-02	1.03e-02	2.27e-02
GO:0042254	80	0.288	0.150	Down	2.12e-02	5.93e-02	4.10e-03	1.31e-02
GO:1901576	518	0.189	0.203	Up	2.13e-02	5.94e-02	1.00e-03	6.73e-03
GO:0006820	41	0.146	0.098	Down	2.15e-02	5.98e-02	2.94e-02	4.91e-02
GO:0006904	4	0.500	0.250	Down	2.19e-02	6.07e-02	1.00e-04	1.34e-03
GO:0009132	5	0.200	0.400	Up	2.22e-02	6.14e-02	9.00e-04	6.35e-03
GO:0010558	4	0.500	0.000	Down	2.24e-02	6.17e-02	2.86e-02	4.83e-02
GO:0022618	29	0.345	0.103	Down	2.26e-02	6.19e-02	1.36e-02	2.81e-02
GO:1901575	165	0.303	0.145	Down	2.26e-02	6.19e-02	3.20e-03	1.16e-02
GO:0007015	4	0.250	0.000	Down	2.29e-02	6.26e-02	2.97e-02	4.93e-02
GO:0006661	10	0.000	0.600	Up	2.30e-02	6.27e-02	2.30e-02	4.11e-02
GO:0006086	4	0.000	0.500	Up	2.31e-02	6.28e-02	3.27e-02	5.26e-02
GO:0048278	4	0.500	0.250	Down	2.34e-02	6.32e-02	2.00e-04	3.08e-03
GO:0031163	4	0.250	0.500	Up	2.34e-02	6.32e-02	3.80e-03	1.26e-02
GO:0022406	4	0.500	0.250	Down	2.36e-02	6.36e-02	2.00e-04	3.08e-03
GO:0006464	206	0.160	0.218	Up	2.38e-02	6.38e-02	1.40e-03	7.93e-03
GO:0051235	3	0.000	0.667	Up	2.39e-02	6.38e-02	1.57e-02	3.12e-02
GO:0016226	4	0.250	0.500	Up	2.40e-02	6.38e-02	3.60e-03	1.24e-02
GO:0035384	4	0.000	0.500	Up	2.40e-02	6.38e-02	3.24e-02	5.26e-02
GO:0009890	5	0.400	0.000	Down	2.40e-02	6.38e-02	3.22e-02	5.23e-02
GO:0006508	138	0.268	0.181	Down	2.50e-02	6.61e-02	1.40e-03	7.93e-03
GO:0035890	12	0.083	0.250	Up	2.50e-02	6.61e-02	5.84e-02	7.87e-02
GO:0036211	206	0.160	0.218	Up	2.51e-02	6.62e-02	1.50e-03	8.22e-03
GO:0044106	8	0.250	0.125	Down	2.53e-02	6.65e-02	1.28e-02	2.70e-02
GO:0006357	10	0.300	0.100	Down	2.58e-02	6.73e-02	1.65e-02	3.22e-02
GO:0006629	86	0.140	0.256	Up	2.58e-02	6.73e-02	4.50e-03	1.40e-02
GO:0006869	9	0.222	0.222	Down	2.58e-02	6.73e-02	1.02e-02	2.26e-02
GO:0032774	84	0.202	0.190	Down	2.60e-02	6.76e-02	1.50e-03	8.22e-03
GO:0031327	5	0.400	0.000	Down	2.61e-02	6.76e-02	3.47e-02	5.40e-02
GO:0019320	9	0.556	0.000	Down	2.62e-02	6.76e-02	2.72e-02	4.70e-02
GO:0043248	8	0.625	0.125	Down	2.63e-02	6.76e-02	1.87e-02	3.57e-02
GO:0006505	10	0.000	0.600	Up	2.63e-02	6.76e-02	2.55e-02	4.48e-02
GO:0006085	4	0.000	0.500	Up	2.64e-02	6.76e-02	3.57e-02	5.50e-02
GO:0018193	25	0.280	0.320	Up	2.64e-02	6.76e-02	3.00e-04	4.38e-03
GO:0006098	9	0.556	0.000	Down	2.65e-02	6.76e-02	2.77e-02	4.73e-02
GO:0009438	2	0.000	0.500	Up	2.66e-02	6.77e-02	5.00e-03	1.49e-02
GO:0032268	27	0.259	0.222	Down	2.69e-02	6.81e-02	4.70e-03	1.42e-02
GO:0042592	47	0.255	0.234	Up	2.69e-02	6.81e-02	1.10e-03	7.13e-03
GO:0010876	9	0.222	0.222	Down	2.70e-02	6.82e-02	8.10e-03	1.94e-02
GO:0070682	6	0.833	0.000	Down	2.71e-02	6.83e-02	2.72e-02	4.70e-02
GO:0050657	7	0.286	0.143	Down	2.75e-02	6.91e-02	3.45e-02	5.40e-02
GO:0034470	83	0.229	0.253	Down	2.76e-02	6.92e-02	1.70e-03	8.55e-03
GO:0046365	9	0.556	0.000	Down	2.77e-02	6.92e-02	2.56e-02	4.48e-02
GO:0044710	420	0.210	0.205	Down	2.78e-02	6.93e-02	1.00e-03	6.73e-03
GO:0006165	2	0.500	0.500	Up	2.81e-02	6.99e-02	1.70e-03	8.55e-03
GO:0050658	7	0.286	0.143	Down	2.82e-02	6.99e-02	3.27e-02	5.26e-02
GO:0006740	9	0.556	0.000	Down	2.84e-02	7.02e-02	2.73e-02	4.70e-02
GO:0046939	2	0.500	0.500	Up	2.86e-02	7.02e-02	2.30e-03	9.98e-03
GO:0010564	17	0.118	0.235	Up	2.86e-02	7.02e-02	3.65e-02	5.59e-02
GO:0051236	7	0.286	0.143	Down	2.87e-02	7.02e-02	3.50e-02	5.42e-02
GO:0009308	8	0.250	0.125	Down	2.87e-02	7.02e-02	1.41e-02	2.86e-02
GO:0051726	29	0.207	0.241	Up	2.88e-02	7.02e-02	6.10e-03	1.62e-02
GO:0006739	9	0.556	0.000	Down	2.89e-02	7.02e-02	2.95e-02	4.91e-02
GO:0006576	8	0.250	0.125	Down	2.89e-02	7.02e-02	1.37e-02	2.82e-02
GO:0044711	147	0.184	0.231	Up	2.92e-02	7.08e-02	7.00e-04	5.91e-03
GO:0032271	5	0.200	0.200	Down	2.93e-02	7.08e-02	6.85e-02	8.98e-02
GO:0042777	1	0.000	1.000	Up	2.96e-02	7.10e-02	2.96e-02	4.92e-02
GO:0006007	9	0.556	0.000	Down	2.96e-02	7.10e-02	2.87e-02	4.84e-02
GO:0019362	10	0.500	0.000	Down	2.96e-02	7.10e-02	3.82e-02	5.75e-02
GO:0006403	7	0.286	0.143	Down	2.97e-02	7.11e-02	3.88e-02	5.81e-02
GO:0046496	10	0.500	0.000	Down	2.98e-02	7.12e-02	4.05e-02	5.98e-02
GO:0044087	5	0.200	0.200	Down	2.99e-02	7.12e-02	6.70e-02	8.88e-02
GO:0032956	5	0.200	0.200	Down	3.03e-02	7.19e-02	6.79e-02	8.93e-02
GO:0008064	5	0.200	0.200	Down	3.04e-02	7.19e-02	6.39e-02	8.55e-02
GO:0030832	5	0.200	0.200	Down	3.04e-02	7.19e-02	6.73e-02	8.90e-02
GO:0006511	71	0.338	0.155	Down	3.05e-02	7.19e-02	3.90e-03	1.28e-02
GO:0090407	64	0.172	0.250	Up	3.06e-02	7.20e-02	1.80e-03	8.79e-03
GO:0071616	4	0.000	0.500	Up	3.08e-02	7.23e-02	4.03e-02	5.97e-02
GO:0015718	7	0.286	0.143	Down	3.14e-02	7.35e-02	9.40e-03	2.15e-02
GO:0006414	20	0.350	0.100	Down	3.17e-02	7.39e-02	1.48e-02	2.97e-02
GO:0033036	161	0.193	0.130	Down	3.17e-02	7.39e-02	4.90e-03	1.46e-02
GO:1901566	80	0.175	0.250	Up	3.18e-02	7.39e-02	4.00e-04	5.11e-03
GO:0030833	5	0.200	0.200	Down	3.19e-02	7.40e-02	6.85e-02	8.98e-02
GO:0043254	5	0.200	0.200	Down	3.21e-02	7.43e-02	6.87e-02	8.99e-02
GO:0016482	66	0.227	0.091	Down	3.23e-02	7.45e-02	1.31e-02	2.76e-02
GO:0006979	10	0.400	0.100	Down	3.27e-02	7.52e-02	2.73e-02	4.70e-02
GO:0032970	5	0.200	0.200	Down	3.28e-02	7.52e-02	6.96e-02	9.07e-02
GO:0007010	21	0.143	0.286	Up	3.29e-02	7.52e-02	5.10e-03	1.49e-02
GO:0051493	5	0.200	0.200	Down	3.29e-02	7.52e-02	6.99e-02	9.09e-02
GO:0032535	5	0.200	0.200	Down	3.30e-02	7.53e-02	7.45e-02	9.54e-02
GO:0008654	25	0.160	0.360	Up	3.31e-02	7.53e-02	5.40e-03	1.52e-02
GO:0051301	23	0.043	0.261	Up	3.33e-02	7.56e-02	2.44e-02	4.30e-02
GO:0018208	10	0.400	0.100	Down	3.34e-02	7.56e-02	6.20e-03	1.65e-02
GO:0000413	10	0.400	0.100	Down	3.36e-02	7.56e-02	5.20e-03	1.50e-02
GO:0006890	6	0.000	0.333	Up	3.36e-02	7.56e-02	4.11e-02	6.03e-02
GO:0006928	33	0.212	0.212	Down	3.36e-02	7.56e-02	2.20e-03	9.78e-03
GO:0006644	35	0.200	0.314	Up	3.41e-02	7.63e-02	2.50e-03	1.02e-02
GO:0009060	17	0.118	0.294	Up	3.41e-02	7.63e-02	1.98e-02	3.68e-02
GO:0008535	1	0.000	1.000	Up	3.45e-02	7.69e-02	3.45e-02	5.40e-02
GO:0035891	11	0.091	0.273	Up	3.45e-02	7.69e-02	6.58e-02	8.75e-02
GO:0008610	53	0.132	0.283	Up	3.46e-02	7.69e-02	1.20e-02	2.58e-02
GO:0090066	5	0.200	0.200	Down	3.47e-02	7.70e-02	7.00e-02	9.09e-02
GO:0019219	110	0.200	0.191	Down	3.48e-02	7.70e-02	2.90e-03	1.09e-02
GO:0051171	110	0.200	0.191	Down	3.55e-02	7.84e-02	2.80e-03	1.07e-02
GO:0044257	76	0.329	0.171	Down	3.60e-02	7.93e-02	4.80e-03	1.44e-02
GO:0006099	17	0.118	0.294	Up	3.61e-02	7.93e-02	1.89e-02	3.59e-02
GO:0051603	76	0.329	0.171	Down	3.63e-02	7.96e-02	4.60e-03	1.41e-02
GO:0043244	3	0.667	0.333	Down	3.64e-02	7.96e-02	1.25e-02	2.65e-02
GO:0044255	73	0.151	0.260	Up	3.66e-02	7.99e-02	7.40e-03	1.82e-02
GO:0006750	3	0.000	0.667	Up	3.68e-02	8.01e-02	3.91e-02	5.84e-02
GO:0043632	73	0.329	0.164	Down	3.69e-02	8.02e-02	5.60e-03	1.54e-02
GO:0009147	3	0.000	0.333	Up	3.72e-02	8.06e-02	5.28e-02	7.27e-02
GO:0097354	6	0.000	0.167	Up	3.74e-02	8.06e-02	1.70e-01	1.99e-01
GO:0043043	3	0.000	0.667	Up	3.75e-02	8.06e-02	3.96e-02	5.90e-02
GO:0018205	6	0.333	0.500	Up	3.75e-02	8.06e-02	1.08e-02	2.35e-02
GO:0031324	6	0.333	0.167	Down	3.75e-02	8.06e-02	1.40e-02	2.85e-02
GO:0034645	383	0.193	0.196	Down	3.77e-02	8.08e-02	2.70e-03	1.05e-02
GO:0019184	3	0.000	0.667	Up	3.84e-02	8.20e-02	3.60e-02	5.54e-02
GO:0015672	24	0.208	0.292	Up	3.84e-02	8.20e-02	2.40e-03	9.98e-03
GO:0019941	73	0.329	0.164	Down	3.94e-02	8.39e-02	5.80e-03	1.57e-02
GO:0018342	6	0.000	0.167	Up	3.97e-02	8.44e-02	1.68e-01	1.98e-01
GO:0016310	99	0.121	0.162	Up	4.00e-02	8.45e-02	8.10e-03	1.94e-02
GO:0006468	91	0.099	0.154	Up	4.00e-02	8.45e-02	1.33e-02	2.77e-02
GO:0007059	8	0.000	0.375	Up	4.01e-02	8.45e-02	4.93e-02	6.89e-02
GO:0009059	385	0.192	0.197	Down	4.01e-02	8.45e-02	1.40e-03	7.93e-03
GO:0016570	11	0.273	0.273	Down	4.02e-02	8.45e-02	4.40e-03	1.37e-02
GO:0046486	25	0.160	0.320	Up	4.03e-02	8.45e-02	5.40e-03	1.52e-02
GO:0043038	40	0.350	0.200	Down	4.04e-02	8.46e-02	5.40e-03	1.52e-02
GO:0018344	3	0.000	0.333	Up	4.05e-02	8.46e-02	9.69e-02	1.19e-01
GO:0006091	41	0.317	0.146	Down	4.06e-02	8.46e-02	3.60e-03	1.24e-02
GO:0044265	97	0.299	0.165	Down	4.10e-02	8.51e-02	4.10e-03	1.31e-02
GO:0006166	2	1.000	0.000	Down	4.11e-02	8.51e-02	4.11e-02	6.03e-02
GO:0032787	53	0.264	0.151	Down	4.11e-02	8.51e-02	1.04e-02	2.28e-02
GO:0032269	1	0.000	1.000	Up	4.14e-02	8.55e-02	4.14e-02	6.03e-02
GO:0043039	40	0.350	0.200	Down	4.17e-02	8.58e-02	5.90e-03	1.59e-02
GO:0016569	11	0.273	0.273	Down	4.17e-02	8.58e-02	5.40e-03	1.52e-02
GO:0006415	5	0.000	0.400	Up	4.20e-02	8.62e-02	1.47e-01	1.74e-01
GO:0008652	20	0.150	0.200	Down	4.21e-02	8.62e-02	1.76e-02	3.39e-02
GO:0043101	2	1.000	0.000	Down	4.23e-02	8.63e-02	4.24e-02	6.12e-02
GO:1902578	203	0.153	0.182	Up	4.23e-02	8.63e-02	4.90e-03	1.46e-02
GO:0006084	5	0.000	0.400	Up	4.25e-02	8.65e-02	5.59e-02	7.60e-02
GO:0043174	2	1.000	0.000	Down	4.29e-02	8.71e-02	4.30e-02	6.17e-02
GO:0043624	5	0.000	0.400	Up	4.31e-02	8.74e-02	1.43e-01	1.69e-01
GO:0051248	1	0.000	1.000	Up	4.33e-02	8.76e-02	4.33e-02	6.20e-02
GO:0072524	12	0.417	0.000	Down	4.40e-02	8.83e-02	7.42e-02	9.52e-02
GO:0071103	19	0.316	0.211	Down	4.40e-02	8.83e-02	9.10e-03	2.11e-02
GO:0009057	101	0.287	0.158	Down	4.40e-02	8.83e-02	6.40e-03	1.67e-02
GO:1901135	97	0.175	0.258	Up	4.40e-02	8.83e-02	1.40e-03	7.93e-03
GO:1901070	2	0.000	0.500	Up	4.41e-02	8.83e-02	1.33e-02	2.77e-02
GO:0043650	3	0.333	0.000	Down	4.46e-02	8.91e-02	5.81e-02	7.85e-02
GO:0030154	7	0.000	0.286	Up	4.49e-02	8.95e-02	6.53e-02	8.71e-02
GO:0002376	7	0.286	0.000	Down	4.52e-02	8.99e-02	2.04e-02	3.74e-02
GO:0032984	8	0.000	0.375	Up	4.60e-02	9.13e-02	5.51e-02	7.53e-02
GO:0006473	6	0.000	0.500	Up	4.61e-02	9.13e-02	1.16e-01	1.40e-01
GO:0022411	8	0.000	0.375	Up	4.65e-02	9.19e-02	5.27e-02	7.27e-02
GO:0006412	231	0.229	0.173	Down	4.71e-02	9.29e-02	4.20e-03	1.34e-02
GO:0030163	86	0.302	0.174	Down	4.74e-02	9.33e-02	3.60e-03	1.24e-02
GO:0043484	2	0.500	0.000	Down	4.76e-02	9.35e-02	9.06e-02	1.13e-01
GO:0051130	3	0.333	0.000	Down	4.78e-02	9.37e-02	1.66e-01	1.95e-01
GO:0009991	7	0.429	0.143	Down	4.81e-02	9.41e-02	1.93e-02	3.63e-02
GO:0001522	17	0.059	0.176	Up	4.82e-02	9.41e-02	5.14e-02	7.10e-02
GO:0031365	4	0.250	0.000	Down	4.84e-02	9.43e-02	6.92e-02	9.03e-02
GO:0018345	8	0.000	0.500	Up	4.88e-02	9.47e-02	6.84e-02	8.98e-02
GO:0040011	58	0.155	0.207	Up	4.88e-02	9.47e-02	3.80e-03	1.26e-02
GO:0044765	199	0.156	0.176	Up	4.93e-02	9.53e-02	2.90e-03	1.09e-02
GO:0006400	19	0.105	0.263	Up	4.94e-02	9.53e-02	3.10e-03	1.14e-02
GO:0006420	3	0.000	0.667	Up	4.95e-02	9.53e-02	1.46e-01	1.72e-01
GO:0051252	87	0.195	0.161	Down	4.95e-02	9.53e-02	1.02e-02	2.26e-02
GO:0006749	4	0.250	0.500	Up	5.01e-02	9.61e-02	1.21e-02	2.59e-02
GO:0006260	47	0.106	0.170	Up	5.01e-02	9.61e-02	1.96e-02	3.67e-02
GO:0044248	137	0.255	0.161	Down	5.02e-02	9.61e-02	4.60e-03	1.41e-02
GO:0046165	6	0.167	0.000	Down	5.08e-02	9.71e-02	7.95e-02	1.01e-01
GO:0006793	226	0.159	0.186	Up	5.21e-02	9.93e-02	3.30e-03	1.17e-02
GO:0009218	2	0.000	0.500	Up	5.34e-02	1.02e-01	1.84e-02	3.53e-02
GO:0006275	3	0.000	0.333	Up	5.36e-02	1.02e-01	8.47e-02	1.07e-01
GO:0051649	138	0.188	0.109	Down	5.37e-02	1.02e-01	5.60e-03	1.54e-02
GO:0046131	2	0.000	0.500	Up	5.40e-02	1.02e-01	1.47e-02	2.96e-02
GO:0051028	4	0.250	0.250	Down	5.41e-02	1.02e-01	3.28e-02	5.26e-02
GO:0051641	142	0.183	0.120	Down	5.41e-02	1.02e-01	3.40e-03	1.20e-02
GO:0030433	19	0.158	0.211	Up	5.44e-02	1.02e-01	2.68e-02	4.65e-02
GO:0015748	6	0.167	0.167	Down	5.44e-02	1.02e-01	2.60e-03	1.05e-02
GO:0055086	85	0.235	0.141	Down	5.46e-02	1.02e-01	3.60e-03	1.24e-02
GO:0023051	21	0.238	0.286	Up	5.48e-02	1.02e-01	6.00e-04	5.76e-03
GO:0006383	7	0.286	0.143	Down	5.50e-02	1.03e-01	6.50e-03	1.68e-02
GO:0034982	2	0.500	0.000	Down	5.54e-02	1.03e-01	5.56e-02	7.58e-02
GO:0052126	54	0.167	0.185	Up	5.55e-02	1.03e-01	3.70e-03	1.25e-02
GO:0042273	16	0.250	0.125	Down	5.59e-02	1.04e-01	3.46e-02	5.40e-02
GO:0009966	21	0.238	0.286	Up	5.60e-02	1.04e-01	7.00e-04	5.91e-03
GO:0052192	54	0.167	0.185	Up	5.60e-02	1.04e-01	3.60e-03	1.24e-02
GO:0033013	8	0.000	0.375	Up	5.63e-02	1.04e-01	7.93e-02	1.01e-01
GO:0010646	21	0.238	0.286	Up	5.65e-02	1.04e-01	7.00e-04	5.91e-03
GO:0046134	2	0.000	0.500	Up	5.69e-02	1.05e-01	1.88e-02	3.58e-02
GO:0009220	2	0.000	0.500	Up	5.73e-02	1.05e-01	1.67e-02	3.24e-02
GO:0006367	8	0.000	0.375	Up	5.75e-02	1.05e-01	3.56e-02	5.50e-02
GO:0020027	7	0.143	0.286	Up	5.80e-02	1.06e-01	1.02e-02	2.26e-02
GO:0006388	2	0.000	0.500	Up	5.81e-02	1.06e-01	6.74e-02	8.91e-02
GO:0031325	4	0.500	0.250	Down	5.82e-02	1.06e-01	1.32e-02	2.77e-02
GO:0000394	2	0.000	0.500	Up	5.84e-02	1.06e-01	7.50e-02	9.58e-02
GO:0046132	2	0.000	0.500	Up	5.85e-02	1.06e-01	1.51e-02	3.02e-02
GO:0010604	4	0.500	0.250	Down	5.88e-02	1.06e-01	1.61e-02	3.18e-02
GO:0042168	8	0.000	0.375	Up	5.89e-02	1.06e-01	8.63e-02	1.08e-01
GO:0006656	4	0.250	0.000	Down	5.89e-02	1.06e-01	3.80e-02	5.74e-02
GO:1902589	44	0.182	0.159	Down	5.89e-02	1.06e-01	3.30e-03	1.17e-02
GO:0008104	148	0.189	0.128	Down	5.91e-02	1.06e-01	6.60e-03	1.70e-02
GO:0006213	2	0.000	0.500	Up	5.97e-02	1.07e-01	1.67e-02	3.24e-02
GO:0009127	11	0.091	0.364	Up	5.97e-02	1.07e-01	5.09e-02	7.05e-02
GO:0015980	24	0.125	0.250	Up	5.97e-02	1.07e-01	3.04e-02	5.00e-02
GO:0006650	24	0.167	0.333	Up	5.99e-02	1.07e-01	5.50e-03	1.53e-02
GO:0042594	3	0.667	0.000	Down	6.02e-02	1.07e-01	4.43e-02	6.30e-02
GO:0042440	8	0.000	0.375	Up	6.02e-02	1.07e-01	8.44e-02	1.07e-01
GO:0006811	79	0.177	0.190	Down	6.08e-02	1.08e-01	2.80e-03	1.07e-02
GO:0042439	4	0.250	0.000	Down	6.10e-02	1.08e-01	3.67e-02	5.61e-02
GO:0046470	4	0.250	0.000	Down	6.13e-02	1.08e-01	3.22e-02	5.23e-02
GO:0031668	5	0.400	0.000	Down	6.15e-02	1.08e-01	1.15e-01	1.39e-01
GO:0043094	3	0.667	0.000	Down	6.18e-02	1.09e-01	9.20e-02	1.14e-01
GO:0051806	42	0.167	0.214	Up	6.22e-02	1.09e-01	2.00e-03	9.12e-03
GO:0046395	7	0.143	0.429	Up	6.23e-02	1.09e-01	6.22e-02	8.34e-02
GO:0016054	7	0.143	0.429	Up	6.27e-02	1.10e-01	6.67e-02	8.86e-02
GO:0009168	11	0.091	0.364	Up	6.30e-02	1.10e-01	5.58e-02	7.60e-02
GO:0022402	21	0.095	0.190	Up	6.30e-02	1.10e-01	5.60e-02	7.60e-02
GO:0006778	8	0.000	0.375	Up	6.31e-02	1.10e-01	8.50e-02	1.07e-01
GO:0045333	23	0.130	0.261	Up	6.32e-02	1.10e-01	2.89e-02	4.85e-02
GO:0048869	8	0.000	0.250	Up	6.33e-02	1.10e-01	7.71e-02	9.81e-02
GO:0071702	174	0.178	0.126	Down	6.34e-02	1.10e-01	9.30e-03	2.14e-02
GO:0034033	4	0.000	0.250	Up	6.36e-02	1.10e-01	4.24e-02	6.12e-02
GO:0030260	42	0.167	0.214	Up	6.37e-02	1.10e-01	2.70e-03	1.05e-02
GO:0017038	19	0.263	0.053	Down	6.44e-02	1.10e-01	5.37e-02	7.37e-02
GO:2001141	85	0.188	0.165	Down	6.46e-02	1.10e-01	9.70e-03	2.20e-02
GO:0042540	7	0.143	0.286	Up	6.47e-02	1.10e-01	1.23e-02	2.62e-02
GO:0034030	4	0.000	0.250	Up	6.47e-02	1.10e-01	4.15e-02	6.03e-02
GO:0015936	4	0.000	0.250	Up	6.49e-02	1.10e-01	4.08e-02	6.02e-02
GO:0030488	4	0.000	0.250	Up	6.49e-02	1.10e-01	5.00e-02	6.94e-02
GO:0046907	134	0.179	0.112	Down	6.49e-02	1.10e-01	5.90e-03	1.59e-02
GO:0051179	346	0.171	0.159	Up	6.49e-02	1.10e-01	4.00e-03	1.30e-02
GO:0015711	18	0.167	0.111	Down	6.50e-02	1.10e-01	9.90e-03	2.23e-02
GO:0045184	143	0.189	0.119	Down	6.51e-02	1.10e-01	8.40e-03	1.99e-02
GO:0006418	38	0.342	0.211	Down	6.56e-02	1.11e-01	7.00e-03	1.77e-02
GO:0009893	4	0.500	0.250	Down	6.58e-02	1.11e-01	1.63e-02	3.20e-02
GO:0033866	4	0.000	0.250	Up	6.59e-02	1.11e-01	4.13e-02	6.03e-02
GO:0033875	4	0.000	0.250	Up	6.60e-02	1.11e-01	4.14e-02	6.03e-02
GO:0072528	14	0.286	0.143	Down	6.61e-02	1.11e-01	1.10e-03	7.13e-03
GO:0044282	7	0.143	0.429	Up	6.63e-02	1.11e-01	6.54e-02	8.71e-02
GO:0016311	15	0.200	0.267	Down	6.63e-02	1.11e-01	6.90e-03	1.76e-02
GO:0015031	142	0.190	0.120	Down	6.63e-02	1.11e-01	7.30e-03	1.80e-02
GO:0034032	4	0.000	0.250	Up	6.72e-02	1.12e-01	3.80e-02	5.74e-02
GO:0033865	4	0.000	0.250	Up	6.73e-02	1.12e-01	4.39e-02	6.26e-02
GO:0055085	69	0.174	0.188	Up	6.74e-02	1.12e-01	5.70e-03	1.55e-02
GO:0006355	85	0.188	0.165	Down	6.78e-02	1.13e-01	1.20e-02	2.58e-02
GO:0009148	2	0.000	0.500	Up	6.80e-02	1.13e-01	4.49e-02	6.36e-02
GO:0044409	46	0.174	0.196	Up	6.82e-02	1.13e-01	2.70e-03	1.05e-02
GO:0030522	2	0.500	0.000	Down	6.87e-02	1.14e-01	1.96e-02	3.67e-02
GO:0006733	15	0.333	0.133	Down	6.97e-02	1.15e-01	2.17e-02	3.94e-02
GO:0002682	6	0.333	0.000	Down	6.98e-02	1.15e-01	2.45e-02	4.31e-02
GO:0046916	3	0.333	0.667	Up	6.99e-02	1.15e-01	4.70e-03	1.42e-02
GO:0015937	4	0.000	0.250	Up	6.99e-02	1.15e-01	4.53e-02	6.40e-02
GO:0060627	23	0.087	0.261	Up	7.06e-02	1.15e-01	3.10e-03	1.14e-02
GO:0019637	115	0.217	0.191	Down	7.06e-02	1.15e-01	1.80e-03	8.79e-03
GO:0015693	1	0.000	1.000	Up	7.09e-02	1.16e-01	7.09e-02	9.19e-02
GO:0071496	5	0.400	0.000	Down	7.10e-02	1.16e-01	1.16e-01	1.40e-01
GO:0017004	2	0.500	0.500	Up	7.11e-02	1.16e-01	2.99e-02	4.94e-02
GO:0000393	5	0.400	0.400	Down	7.12e-02	1.16e-01	7.80e-03	1.89e-02
GO:0006887	5	0.400	0.200	Down	7.15e-02	1.16e-01	4.00e-04	5.11e-03
GO:0071822	51	0.235	0.196	Down	7.15e-02	1.16e-01	3.80e-03	1.26e-02
GO:0042180	6	0.000	0.333	Up	7.19e-02	1.16e-01	6.75e-02	8.91e-02
GO:0009150	40	0.150	0.250	Up	7.21e-02	1.16e-01	3.10e-03	1.14e-02
GO:0051828	46	0.174	0.196	Up	7.29e-02	1.17e-01	1.80e-03	8.79e-03
GO:0046903	5	0.400	0.200	Down	7.37e-02	1.19e-01	3.00e-04	4.38e-03
GO:0050776	6	0.333	0.000	Down	7.43e-02	1.19e-01	2.24e-02	4.03e-02
GO:0055076	3	0.333	0.667	Up	7.49e-02	1.20e-01	5.20e-03	1.50e-02
GO:0032940	5	0.400	0.200	Down	7.50e-02	1.20e-01	3.00e-04	4.38e-03
GO:0042181	6	0.000	0.333	Up	7.52e-02	1.20e-01	7.17e-02	9.26e-02
GO:0006886	102	0.196	0.108	Down	7.59e-02	1.21e-01	9.10e-03	2.11e-02
GO:0034613	106	0.189	0.123	Down	7.69e-02	1.22e-01	6.80e-03	1.74e-02
GO:0051234	333	0.171	0.150	Up	7.70e-02	1.22e-01	3.60e-03	1.24e-02
GO:0070727	106	0.189	0.123	Down	7.76e-02	1.23e-01	7.20e-03	1.79e-02
GO:1901661	6	0.000	0.333	Up	7.82e-02	1.24e-01	7.72e-02	9.81e-02
GO:0006796	219	0.164	0.178	Up	7.83e-02	1.24e-01	3.20e-03	1.16e-02
GO:0006810	332	0.172	0.151	Up	7.89e-02	1.25e-01	3.90e-03	1.28e-02
GO:0006487	2	0.000	0.500	Up	7.97e-02	1.26e-01	1.72e-01	2.02e-01
GO:0017183	5	0.200	0.400	Up	8.07e-02	1.27e-01	1.64e-02	3.21e-02
GO:0007017	31	0.194	0.194	Up	8.08e-02	1.27e-01	3.20e-03	1.16e-02
GO:0009124	12	0.083	0.333	Up	8.12e-02	1.27e-01	5.82e-02	7.85e-02
GO:1901663	6	0.000	0.333	Up	8.16e-02	1.28e-01	7.55e-02	9.63e-02
GO:0048870	10	0.100	0.300	Up	8.19e-02	1.28e-01	4.98e-02	6.92e-02
GO:0055114	95	0.211	0.221	Up	8.21e-02	1.28e-01	1.00e-03	6.73e-03
GO:0006873	11	0.091	0.364	Up	8.22e-02	1.28e-01	1.41e-02	2.86e-02
GO:0030003	11	0.091	0.364	Up	8.28e-02	1.29e-01	1.40e-02	2.85e-02
GO:0009156	12	0.083	0.333	Up	8.41e-02	1.31e-01	6.08e-02	8.18e-02
GO:0009259	41	0.146	0.244	Up	8.42e-02	1.31e-01	4.00e-03	1.30e-02
GO:0046034	12	0.167	0.417	Up	8.45e-02	1.31e-01	2.94e-02	4.91e-02
GO:0051674	10	0.100	0.300	Up	8.57e-02	1.32e-01	5.30e-02	7.29e-02
GO:0017182	5	0.200	0.400	Up	8.58e-02	1.32e-01	1.58e-02	3.14e-02
GO:0007186	4	0.000	0.250	Up	8.74e-02	1.35e-01	1.75e-01	2.05e-01
GO:0006366	21	0.143	0.238	Up	8.77e-02	1.35e-01	1.46e-02	2.95e-02
GO:0031667	4	0.500	0.250	Down	8.82e-02	1.36e-01	7.20e-03	1.79e-02
GO:0019693	42	0.143	0.238	Up	8.86e-02	1.36e-01	4.30e-03	1.36e-02
GO:0015988	14	0.214	0.357	Up	8.88e-02	1.36e-01	3.30e-03	1.17e-02
GO:0034227	3	0.000	0.333	Up	8.95e-02	1.37e-01	1.36e-01	1.61e-01
GO:0015991	14	0.214	0.357	Up	9.03e-02	1.38e-01	2.80e-03	1.07e-02
GO:0006826	3	0.333	0.000	Down	9.06e-02	1.38e-01	6.88e-02	8.99e-02
GO:0046488	18	0.167	0.333	Up	9.07e-02	1.38e-01	1.05e-02	2.30e-02
GO:0098655	17	0.176	0.294	Up	9.15e-02	1.39e-01	8.90e-03	2.09e-02
GO:1901657	48	0.208	0.229	Down	9.18e-02	1.39e-01	1.10e-03	7.13e-03
GO:0048878	14	0.143	0.357	Up	9.21e-02	1.40e-01	5.40e-03	1.52e-02
GO:0015684	3	0.333	0.000	Down	9.29e-02	1.40e-01	7.17e-02	9.26e-02
GO:0030150	3	0.667	0.000	Down	9.38e-02	1.42e-01	4.28e-02	6.16e-02
GO:0009199	30	0.167	0.300	Up	9.55e-02	1.44e-01	2.40e-03	9.98e-03
GO:0034220	19	0.211	0.263	Up	9.56e-02	1.44e-01	6.00e-04	5.76e-03
GO:0098660	17	0.176	0.294	Up	9.69e-02	1.46e-01	1.03e-02	2.27e-02
GO:0070271	42	0.262	0.190	Down	9.71e-02	1.46e-01	5.60e-03	1.54e-02
GO:0051259	6	0.167	0.167	Up	9.72e-02	1.46e-01	2.66e-02	4.64e-02
GO:0098662	17	0.176	0.294	Up	9.76e-02	1.46e-01	1.02e-02	2.26e-02
GO:0006461	42	0.262	0.190	Down	9.80e-02	1.46e-01	5.40e-03	1.52e-02
GO:0006817	22	0.136	0.045	Down	9.96e-02	1.49e-01	2.61e-01	2.92e-01
GO:0006334	6	0.333	0.333	Down	9.99e-02	1.49e-01	2.04e-02	3.74e-02
GO:0009205	30	0.167	0.300	Up	9.99e-02	1.49e-01	2.50e-03	1.02e-02
GO:0030258	4	0.250	0.250	Down	1.00e-01	1.49e-01	6.39e-02	8.55e-02
GO:0034728	6	0.333	0.333	Down	1.01e-01	1.49e-01	2.19e-02	3.96e-02
GO:0000278	13	0.000	0.154	Up	1.01e-01	1.49e-01	2.46e-01	2.76e-01
GO:0006665	2	0.000	1.000	Up	1.01e-01	1.50e-01	1.03e-01	1.27e-01
GO:0044283	59	0.119	0.186	Up	1.02e-01	1.51e-01	1.24e-02	2.64e-02
GO:1901615	13	0.154	0.000	Down	1.04e-01	1.53e-01	2.31e-01	2.61e-01
GO:0071705	16	0.188	0.125	Down	1.05e-01	1.54e-01	2.40e-02	4.25e-02
GO:0071824	11	0.273	0.182	Down	1.05e-01	1.54e-01	4.30e-02	6.17e-02
GO:0007166	8	0.125	0.125	Up	1.05e-01	1.54e-01	3.64e-02	5.58e-02
GO:0065004	11	0.273	0.182	Down	1.05e-01	1.54e-01	4.35e-02	6.22e-02
GO:0009116	47	0.213	0.234	Down	1.06e-01	1.54e-01	1.60e-03	8.44e-03
GO:0009117	71	0.211	0.155	Down	1.06e-01	1.54e-01	3.80e-03	1.26e-02
GO:0006825	3	0.000	0.333	Up	1.06e-01	1.54e-01	1.13e-01	1.38e-01
GO:0010256	4	0.000	0.250	Up	1.06e-01	1.54e-01	1.89e-01	2.19e-01
GO:0006310	18	0.167	0.111	Down	1.06e-01	1.54e-01	1.98e-02	3.68e-02
GO:0006220	8	0.250	0.125	Up	1.07e-01	1.55e-01	3.18e-02	5.20e-02
GO:0015074	3	0.333	0.000	Down	1.08e-01	1.56e-01	1.20e-01	1.44e-01
GO:0009165	36	0.194	0.194	Up	1.08e-01	1.56e-01	2.20e-03	9.78e-03
GO:0006376	3	0.333	0.333	Down	1.08e-01	1.56e-01	3.31e-02	5.28e-02
GO:0000003	3	0.333	0.000	Down	1.08e-01	1.56e-01	1.72e-01	2.02e-01
GO:0032483	13	0.231	0.231	Down	1.09e-01	1.57e-01	8.00e-03	1.93e-02
GO:0072527	15	0.267	0.133	Up	1.09e-01	1.57e-01	2.70e-03	1.05e-02
GO:0055082	12	0.083	0.333	Up	1.09e-01	1.57e-01	1.68e-02	3.25e-02
GO:0032313	13	0.231	0.231	Down	1.09e-01	1.57e-01	9.00e-03	2.10e-02
GO:1901293	37	0.189	0.189	Up	1.11e-01	1.58e-01	3.00e-03	1.12e-02
GO:0015698	23	0.130	0.087	Down	1.11e-01	1.59e-01	2.14e-01	2.43e-01
GO:0050801	12	0.167	0.333	Up	1.12e-01	1.60e-01	4.70e-03	1.42e-02
GO:0055080	12	0.167	0.333	Up	1.13e-01	1.60e-01	5.10e-03	1.49e-02
GO:1901565	31	0.161	0.161	Down	1.13e-01	1.61e-01	3.31e-02	5.28e-02
GO:0016192	83	0.145	0.157	Up	1.13e-01	1.61e-01	9.20e-03	2.13e-02
GO:1902600	16	0.188	0.312	Up	1.14e-01	1.61e-01	8.50e-03	2.01e-02
GO:0010498	21	0.190	0.190	Up	1.14e-01	1.62e-01	3.04e-02	5.00e-02
GO:0006766	8	0.125	0.250	Up	1.16e-01	1.64e-01	3.44e-02	5.40e-02
GO:0043161	21	0.190	0.190	Up	1.17e-01	1.65e-01	3.32e-02	5.28e-02
GO:0007154	59	0.169	0.102	Down	1.19e-01	1.68e-01	1.26e-02	2.66e-02
GO:0006352	14	0.071	0.286	Up	1.20e-01	1.68e-01	3.12e-02	5.12e-02
GO:0045047	7	0.143	0.143	Down	1.20e-01	1.68e-01	4.78e-02	6.70e-02
GO:0006163	43	0.163	0.233	Up	1.20e-01	1.68e-01	2.60e-03	1.05e-02
GO:0009144	31	0.194	0.290	Up	1.20e-01	1.69e-01	2.10e-03	9.45e-03
GO:0072599	7	0.143	0.143	Down	1.22e-01	1.71e-01	4.72e-02	6.63e-02
GO:0006612	7	0.143	0.143	Down	1.22e-01	1.71e-01	4.74e-02	6.65e-02
GO:1903047	12	0.000	0.167	Up	1.23e-01	1.71e-01	2.82e-01	3.13e-01
GO:0051260	3	0.333	0.000	Down	1.23e-01	1.72e-01	2.19e-01	2.49e-01
GO:0042364	8	0.125	0.250	Up	1.25e-01	1.74e-01	3.80e-02	5.74e-02
GO:0043623	26	0.308	0.192	Down	1.26e-01	1.75e-01	7.20e-03	1.79e-02
GO:0009262	7	0.143	0.143	Up	1.26e-01	1.75e-01	2.99e-02	4.94e-02
GO:0006767	8	0.125	0.250	Up	1.26e-01	1.75e-01	3.92e-02	5.85e-02
GO:0008295	3	0.000	0.333	Up	1.28e-01	1.77e-01	7.18e-02	9.26e-02
GO:0009110	8	0.125	0.250	Up	1.28e-01	1.78e-01	4.12e-02	6.03e-02
GO:0042401	3	0.000	0.333	Up	1.32e-01	1.82e-01	7.33e-02	9.43e-02
GO:1902582	80	0.162	0.125	Down	1.32e-01	1.82e-01	1.67e-02	3.24e-02
GO:0006753	73	0.205	0.151	Down	1.32e-01	1.82e-01	4.80e-03	1.44e-02
GO:0006596	3	0.000	0.333	Up	1.32e-01	1.82e-01	7.58e-02	9.66e-02
GO:0006261	27	0.148	0.222	Up	1.33e-01	1.82e-01	3.46e-02	5.40e-02
GO:0016567	11	0.182	0.182	Down	1.33e-01	1.82e-01	2.15e-02	3.91e-02
GO:0019751	3	0.333	0.000	Down	1.34e-01	1.83e-01	2.41e-01	2.70e-01
GO:0006744	5	0.000	0.400	Up	1.34e-01	1.84e-01	9.56e-02	1.18e-01
GO:0009309	3	0.000	0.333	Up	1.35e-01	1.84e-01	7.33e-02	9.43e-02
GO:0006743	5	0.000	0.400	Up	1.37e-01	1.87e-01	1.05e-01	1.28e-01
GO:0009119	46	0.196	0.239	Down	1.37e-01	1.87e-01	1.50e-03	8.22e-03
GO:0051258	8	0.000	0.250	Up	1.37e-01	1.87e-01	2.69e-01	3.01e-01
GO:0006536	5	0.200	0.000	Down	1.39e-01	1.88e-01	9.63e-02	1.19e-01
GO:0009141	34	0.176	0.265	Up	1.39e-01	1.88e-01	5.40e-03	1.52e-02
GO:1901617	9	0.111	0.000	Down	1.39e-01	1.89e-01	2.07e-01	2.38e-01
GO:0006772	4	0.250	0.250	Up	1.39e-01	1.89e-01	3.13e-02	5.13e-02
GO:0043413	7	0.000	0.286	Up	1.40e-01	1.89e-01	2.12e-01	2.42e-01
GO:0009228	4	0.250	0.250	Up	1.42e-01	1.92e-01	3.37e-02	5.33e-02
GO:0046128	41	0.171	0.244	Up	1.43e-01	1.92e-01	3.30e-03	1.17e-02
GO:0042278	41	0.171	0.244	Up	1.43e-01	1.92e-01	3.70e-03	1.25e-02
GO:0006323	10	0.200	0.200	Down	1.43e-01	1.92e-01	5.65e-02	7.65e-02
GO:0009263	4	0.000	0.250	Up	1.43e-01	1.92e-01	5.60e-02	7.60e-02
GO:0006486	7	0.000	0.286	Up	1.44e-01	1.92e-01	2.07e-01	2.38e-01
GO:0042724	4	0.250	0.250	Up	1.44e-01	1.92e-01	3.26e-02	5.26e-02
GO:0032392	6	0.333	0.167	Down	1.45e-01	1.93e-01	7.12e-02	9.22e-02
GO:0009101	7	0.000	0.286	Up	1.45e-01	1.93e-01	2.07e-01	2.38e-01
GO:0042723	4	0.250	0.250	Up	1.46e-01	1.94e-01	3.28e-02	5.26e-02
GO:0070085	7	0.000	0.286	Up	1.46e-01	1.94e-01	2.12e-01	2.42e-01
GO:0044262	11	0.273	0.091	Down	1.46e-01	1.94e-01	9.82e-02	1.21e-01
GO:0009100	7	0.000	0.286	Up	1.47e-01	1.95e-01	2.12e-01	2.42e-01
GO:0008643	4	0.000	0.250	Up	1.48e-01	1.95e-01	2.71e-01	3.02e-01
GO:0007165	54	0.148	0.111	Up	1.48e-01	1.96e-01	1.60e-02	3.16e-02
GO:0032508	6	0.333	0.167	Down	1.49e-01	1.96e-01	6.97e-02	9.07e-02
GO:0006470	11	0.182	0.364	Up	1.49e-01	1.96e-01	1.97e-02	3.68e-02
GO:0023052	54	0.148	0.111	Up	1.50e-01	1.97e-01	1.38e-02	2.83e-02
GO:0006401	10	0.200	0.100	Down	1.50e-01	1.97e-01	9.03e-02	1.13e-01
GO:0010639	3	0.333	0.333	Down	1.50e-01	1.97e-01	3.44e-02	5.40e-02
GO:0006432	3	0.333	0.000	Up	1.51e-01	1.97e-01	8.19e-02	1.04e-01
GO:0051494	3	0.333	0.333	Down	1.51e-01	1.97e-01	3.81e-02	5.74e-02
GO:0018202	6	0.167	0.333	Up	1.51e-01	1.97e-01	4.53e-02	6.40e-02
GO:1901658	19	0.158	0.158	Down	1.51e-01	1.98e-01	3.20e-02	5.22e-02
GO:0006631	29	0.103	0.172	Up	1.52e-01	1.98e-01	2.26e-01	2.55e-01
GO:0042454	19	0.158	0.158	Down	1.52e-01	1.98e-01	2.78e-02	4.73e-02
GO:0019439	37	0.162	0.108	Down	1.52e-01	1.98e-01	3.57e-02	5.50e-02
GO:0044700	54	0.148	0.111	Up	1.54e-01	2.00e-01	1.51e-02	3.02e-02
GO:0006152	19	0.158	0.158	Down	1.54e-01	2.00e-01	3.02e-02	4.98e-02
GO:0046130	19	0.158	0.158	Down	1.55e-01	2.01e-01	3.18e-02	5.20e-02
GO:1901361	39	0.154	0.103	Down	1.57e-01	2.03e-01	3.62e-02	5.56e-02
GO:0030837	3	0.333	0.333	Down	1.57e-01	2.03e-01	3.81e-02	5.74e-02
GO:0032446	18	0.167	0.167	Down	1.58e-01	2.03e-01	2.22e-02	4.00e-02
GO:0009207	17	0.176	0.176	Down	1.59e-01	2.04e-01	2.36e-02	4.20e-02
GO:0031333	3	0.333	0.333	Down	1.59e-01	2.04e-01	3.72e-02	5.67e-02
GO:0046700	39	0.154	0.103	Down	1.59e-01	2.04e-01	4.03e-02	5.97e-02
GO:0048193	26	0.115	0.192	Up	1.60e-01	2.04e-01	2.82e-02	4.78e-02
GO:0051129	3	0.333	0.333	Down	1.60e-01	2.04e-01	3.97e-02	5.91e-02
GO:0000956	5	0.200	0.000	Down	1.60e-01	2.04e-01	2.79e-01	3.10e-01
GO:1901069	17	0.176	0.176	Down	1.60e-01	2.04e-01	2.04e-02	3.74e-02
GO:0032272	3	0.333	0.333	Down	1.60e-01	2.04e-01	3.83e-02	5.75e-02
GO:0031497	7	0.286	0.286	Down	1.61e-01	2.05e-01	2.75e-02	4.72e-02
GO:0009146	17	0.176	0.176	Down	1.62e-01	2.06e-01	2.37e-02	4.21e-02
GO:0072523	19	0.158	0.158	Down	1.62e-01	2.06e-01	3.34e-02	5.30e-02
GO:0006195	18	0.167	0.167	Down	1.62e-01	2.06e-01	2.77e-02	4.73e-02
GO:0009164	19	0.158	0.158	Down	1.62e-01	2.06e-01	2.95e-02	4.91e-02
GO:0009261	18	0.167	0.167	Down	1.63e-01	2.06e-01	2.92e-02	4.90e-02
GO:0048522	8	0.250	0.125	Down	1.63e-01	2.06e-01	7.49e-02	9.58e-02
GO:0009154	18	0.167	0.167	Down	1.64e-01	2.07e-01	2.72e-02	4.70e-02
GO:0006184	17	0.176	0.176	Down	1.64e-01	2.07e-01	2.27e-02	4.07e-02
GO:0034655	35	0.171	0.114	Down	1.65e-01	2.08e-01	3.32e-02	5.28e-02
GO:0000041	7	0.143	0.143	Up	1.65e-01	2.08e-01	3.44e-02	5.40e-02
GO:0009203	17	0.176	0.176	Down	1.67e-01	2.10e-01	2.01e-02	3.72e-02
GO:0006544	4	0.000	0.500	Up	1.68e-01	2.10e-01	1.96e-01	2.27e-01
GO:0044270	39	0.154	0.103	Down	1.68e-01	2.10e-01	4.28e-02	6.16e-02
GO:0015992	19	0.211	0.263	Up	1.69e-01	2.11e-01	5.60e-03	1.54e-02
GO:0006446	9	0.222	0.222	Up	1.70e-01	2.12e-01	2.22e-02	4.00e-02
GO:1901136	23	0.174	0.130	Down	1.71e-01	2.13e-01	4.16e-02	6.03e-02
GO:0006818	19	0.211	0.263	Up	1.72e-01	2.15e-01	6.30e-03	1.66e-02
GO:0006284	4	0.500	0.000	Down	1.72e-01	2.15e-01	8.68e-02	1.09e-01
GO:0051052	4	0.000	0.250	Up	1.74e-01	2.16e-01	6.70e-02	8.88e-02
GO:0006298	8	0.000	0.250	Up	1.77e-01	2.20e-01	2.13e-01	2.42e-01
GO:0070838	6	0.333	0.333	Down	1.78e-01	2.20e-01	1.06e-02	2.32e-02
GO:0070972	8	0.125	0.250	Down	1.81e-01	2.24e-01	2.30e-02	4.11e-02
GO:0043604	5	0.000	0.400	Up	1.82e-01	2.25e-01	1.21e-01	1.45e-01
GO:0072511	6	0.333	0.333	Down	1.83e-01	2.26e-01	1.17e-02	2.53e-02
GO:0051169	25	0.160	0.040	Down	1.83e-01	2.26e-01	1.95e-01	2.26e-01
GO:0006118	4	0.000	0.250	Up	1.86e-01	2.29e-01	3.13e-01	3.44e-01
GO:0006913	25	0.160	0.040	Down	1.87e-01	2.30e-01	1.99e-01	2.30e-01
GO:1901068	19	0.158	0.211	Down	1.88e-01	2.31e-01	8.20e-03	1.95e-02
GO:0008216	4	0.250	0.250	Down	1.88e-01	2.31e-01	4.40e-02	6.27e-02
GO:0072521	48	0.188	0.208	Up	1.90e-01	2.33e-01	2.80e-03	1.07e-02
GO:0006434	3	0.333	0.000	Down	1.91e-01	2.34e-01	1.52e-01	1.80e-01
GO:0009186	4	0.250	0.250	Up	1.92e-01	2.35e-01	1.87e-02	3.57e-02
GO:0006595	4	0.250	0.250	Down	1.97e-01	2.40e-01	4.15e-02	6.03e-02
GO:0006221	7	0.286	0.143	Down	1.99e-01	2.43e-01	2.78e-02	4.73e-02
GO:0006402	7	0.143	0.000	Down	2.00e-01	2.44e-01	2.37e-01	2.67e-01
GO:0046039	18	0.167	0.222	Down	2.02e-01	2.46e-01	8.40e-03	1.99e-02
GO:0044417	4	0.000	0.250	Up	2.02e-01	2.46e-01	1.19e-01	1.44e-01
GO:0031334	2	0.000	0.000	Down	2.07e-01	2.52e-01	3.66e-01	3.95e-01
GO:0042274	9	0.222	0.222	Down	2.09e-01	2.53e-01	2.32e-02	4.14e-02
GO:0044053	4	0.000	0.250	Up	2.09e-01	2.53e-01	1.24e-01	1.48e-01
GO:0051836	4	0.000	0.250	Up	2.09e-01	2.53e-01	1.18e-01	1.43e-01
GO:0042000	4	0.000	0.250	Up	2.09e-01	2.53e-01	1.17e-01	1.42e-01
GO:0010638	2	0.000	0.000	Down	2.10e-01	2.53e-01	3.72e-01	4.00e-01
GO:0051808	4	0.000	0.250	Up	2.12e-01	2.54e-01	1.18e-01	1.42e-01
GO:0035556	36	0.167	0.111	Down	2.12e-01	2.54e-01	3.36e-02	5.32e-02
GO:0006855	3	0.000	0.000	Up	2.12e-01	2.54e-01	2.18e-01	2.48e-01
GO:0051495	2	0.000	0.000	Down	2.12e-01	2.54e-01	3.73e-01	4.01e-01
GO:0072330	21	0.095	0.143	Up	2.12e-01	2.54e-01	2.88e-01	3.18e-01
GO:0030838	2	0.000	0.000	Down	2.12e-01	2.54e-01	3.69e-01	3.97e-01
GO:1902579	4	0.000	0.250	Up	2.15e-01	2.56e-01	1.21e-01	1.45e-01
GO:0015931	11	0.182	0.182	Down	2.15e-01	2.56e-01	5.44e-02	7.44e-02
GO:0045010	2	0.000	0.000	Down	2.16e-01	2.58e-01	3.71e-01	3.99e-01
GO:0044766	4	0.000	0.250	Up	2.16e-01	2.58e-01	1.25e-01	1.49e-01
GO:0032273	2	0.000	0.000	Down	2.17e-01	2.59e-01	3.79e-01	4.07e-01
GO:0009166	19	0.158	0.158	Down	2.19e-01	2.60e-01	3.88e-02	5.81e-02
GO:0015893	3	0.000	0.000	Up	2.21e-01	2.62e-01	2.23e-01	2.52e-01
GO:0071897	1	0.000	0.000	Up	2.23e-01	2.64e-01	2.23e-01	2.52e-01
GO:0015858	3	0.000	0.333	Up	2.26e-01	2.67e-01	2.02e-01	2.33e-01
GO:0006633	19	0.105	0.158	Up	2.29e-01	2.71e-01	2.40e-01	2.70e-01
GO:0009143	18	0.167	0.167	Down	2.32e-01	2.75e-01	3.48e-02	5.41e-02
GO:0006333	12	0.250	0.250	Down	2.36e-01	2.79e-01	4.94e-02	6.89e-02
GO:0030261	2	0.000	0.000	Down	2.37e-01	2.79e-01	3.60e-01	3.90e-01
GO:0006914	6	0.333	0.000	Down	2.38e-01	2.80e-01	2.03e-01	2.34e-01
GO:0009126	17	0.118	0.294	Up	2.39e-01	2.81e-01	8.89e-02	1.11e-01
GO:0009167	17	0.118	0.294	Up	2.39e-01	2.81e-01	9.16e-02	1.14e-01
GO:0006405	4	0.250	0.250	Down	2.41e-01	2.83e-01	5.33e-02	7.32e-02
GO:0009064	9	0.111	0.111	Down	2.50e-01	2.93e-01	7.80e-02	9.90e-02
GO:0006512	5	0.400	0.000	Down	2.55e-01	2.98e-01	9.86e-02	1.21e-01
GO:0046434	22	0.182	0.136	Down	2.59e-01	3.03e-01	4.15e-02	6.03e-02
GO:0051247	3	0.333	0.333	Up	2.60e-01	3.03e-01	3.78e-02	5.74e-02
GO:0015849	13	0.154	0.077	Down	2.60e-01	3.03e-01	9.44e-02	1.17e-01
GO:0032270	3	0.333	0.333	Up	2.62e-01	3.05e-01	3.50e-02	5.42e-02
GO:0007034	5	0.200	0.200	Down	2.63e-01	3.06e-01	4.23e-02	6.12e-02
GO:0052652	2	0.500	0.000	Down	2.64e-01	3.06e-01	1.15e-01	1.39e-01
GO:0046068	2	0.500	0.000	Down	2.68e-01	3.11e-01	1.14e-01	1.38e-01
GO:0046394	39	0.128	0.179	Up	2.71e-01	3.14e-01	4.47e-02	6.35e-02
GO:0009063	6	0.167	0.333	Up	2.71e-01	3.14e-01	1.72e-01	2.02e-01
GO:0046942	13	0.154	0.077	Down	2.72e-01	3.14e-01	9.80e-02	1.20e-01
GO:1901264	5	0.000	0.200	Up	2.74e-01	3.16e-01	3.00e-01	3.30e-01
GO:0016053	39	0.128	0.179	Up	2.76e-01	3.18e-01	4.98e-02	6.92e-02
GO:0000226	5	0.000	0.200	Up	2.78e-01	3.20e-01	3.87e-01	4.14e-01
GO:1901606	6	0.167	0.333	Up	2.78e-01	3.20e-01	1.75e-01	2.04e-01
GO:0044093	4	0.250	0.250	Down	2.80e-01	3.22e-01	6.40e-02	8.55e-02
GO:0009123	18	0.111	0.278	Up	2.82e-01	3.23e-01	8.71e-02	1.09e-01
GO:0019692	3	0.333	0.000	Down	2.82e-01	3.23e-01	1.18e-01	1.43e-01
GO:0043952	5	0.200	0.200	Down	2.85e-01	3.26e-01	2.81e-02	4.77e-02
GO:0009200	3	0.333	0.000	Down	2.86e-01	3.27e-01	1.21e-01	1.45e-01
GO:0043085	4	0.250	0.250	Down	2.87e-01	3.27e-01	6.79e-02	8.93e-02
GO:0009394	3	0.333	0.000	Down	2.87e-01	3.27e-01	1.23e-01	1.47e-01
GO:0007264	24	0.167	0.125	Down	2.90e-01	3.30e-01	4.05e-02	5.98e-02
GO:0006370	3	0.000	0.000	Down	2.92e-01	3.32e-01	3.04e-01	3.34e-01
GO:0009069	7	0.000	0.286	Up	2.93e-01	3.33e-01	2.41e-01	2.70e-01
GO:1901292	20	0.150	0.150	Down	2.94e-01	3.34e-01	5.38e-02	7.37e-02
GO:0009161	18	0.111	0.278	Up	2.95e-01	3.34e-01	9.50e-02	1.17e-01
GO:0040029	3	0.333	0.000	Down	3.03e-01	3.43e-01	2.83e-01	3.14e-01
GO:0006429	2	0.500	0.000	Down	3.06e-01	3.46e-01	2.00e-01	2.31e-01
GO:0006360	3	0.333	0.000	Down	3.07e-01	3.47e-01	8.80e-02	1.10e-01
GO:0006720	7	0.143	0.143	Down	3.11e-01	3.51e-01	3.57e-02	5.50e-02
GO:0007067	11	0.000	0.091	Up	3.11e-01	3.51e-01	5.29e-01	5.50e-01
GO:0008299	7	0.143	0.143	Down	3.15e-01	3.54e-01	3.73e-02	5.68e-02
GO:0016458	3	0.333	0.333	Down	3.15e-01	3.55e-01	4.13e-02	6.03e-02
GO:0006040	4	0.250	0.250	Up	3.18e-01	3.58e-01	9.36e-02	1.16e-01
GO:0016925	4	0.250	0.250	Down	3.22e-01	3.62e-01	4.59e-02	6.47e-02
GO:0006269	2	0.000	0.500	Up	3.25e-01	3.64e-01	2.89e-01	3.20e-01
GO:0006072	5	0.400	0.200	Down	3.27e-01	3.66e-01	1.10e-01	1.35e-01
GO:0052646	6	0.333	0.333	Up	3.29e-01	3.68e-01	4.37e-02	6.24e-02
GO:0007169	3	0.000	0.000	Up	3.44e-01	3.84e-01	4.87e-01	5.12e-01
GO:0006302	5	0.000	0.200	Up	3.47e-01	3.88e-01	3.28e-01	3.59e-01
GO:0007167	3	0.000	0.000	Up	3.51e-01	3.91e-01	4.88e-01	5.12e-01
GO:1901071	3	0.333	0.333	Down	3.55e-01	3.95e-01	1.27e-01	1.52e-01
GO:0009190	3	0.333	0.000	Down	3.55e-01	3.95e-01	2.37e-01	2.67e-01
GO:0051168	8	0.125	0.125	Down	3.64e-01	4.04e-01	2.30e-01	2.60e-01
GO:0000027	8	0.125	0.000	Down	3.65e-01	4.05e-01	2.92e-01	3.22e-01
GO:0006119	3	0.333	0.333	Down	3.72e-01	4.12e-01	1.30e-01	1.55e-01
GO:0002377	3	0.000	0.000	Up	3.77e-01	4.17e-01	2.12e-01	2.42e-01
GO:0002440	3	0.000	0.000	Up	3.77e-01	4.17e-01	2.09e-01	2.40e-01
GO:0070925	15	0.133	0.067	Down	3.80e-01	4.19e-01	2.93e-01	3.23e-01
GO:0042773	3	0.333	0.333	Down	3.81e-01	4.20e-01	1.28e-01	1.52e-01
GO:0009070	2	0.000	0.500	Up	3.82e-01	4.21e-01	2.22e-01	2.52e-01
GO:0009187	4	0.250	0.000	Down	3.90e-01	4.29e-01	3.80e-01	4.08e-01
GO:0008645	2	0.000	0.000	Up	3.91e-01	4.30e-01	5.05e-01	5.30e-01
GO:0015749	2	0.000	0.000	Up	3.94e-01	4.32e-01	5.13e-01	5.37e-01
GO:0006268	2	0.500	0.000	Down	3.95e-01	4.33e-01	3.39e-01	3.68e-01
GO:0006270	11	0.091	0.182	Up	3.96e-01	4.34e-01	1.86e-01	2.16e-01
GO:0009066	4	0.250	0.000	Down	3.97e-01	4.35e-01	6.64e-01	6.76e-01
GO:0009084	3	0.000	0.000	Down	3.99e-01	4.36e-01	5.27e-01	5.49e-01
GO:0006611	3	0.000	0.333	Up	4.12e-01	4.50e-01	1.83e-01	2.13e-01
GO:0006122	2	0.000	0.500	Up	4.13e-01	4.51e-01	3.52e-01	3.81e-01
GO:0042775	2	0.000	0.500	Up	4.17e-01	4.54e-01	3.51e-01	3.81e-01
GO:0006614	5	0.200	0.200	Down	4.33e-01	4.71e-01	9.28e-02	1.15e-01
GO:0006613	5	0.200	0.200	Down	4.36e-01	4.74e-01	9.49e-02	1.17e-01
GO:0030048	4	0.250	0.250	Up	4.37e-01	4.74e-01	8.63e-02	1.08e-01
GO:0050793	4	0.000	0.250	Up	4.38e-01	4.75e-01	2.79e-01	3.10e-01
GO:0046777	1	0.000	0.000	Up	4.40e-01	4.76e-01	4.40e-01	4.65e-01
GO:0000302	3	0.000	0.000	Up	4.40e-01	4.76e-01	5.27e-01	5.49e-01
GO:1901700	3	0.000	0.000	Up	4.41e-01	4.77e-01	5.28e-01	5.49e-01
GO:0006546	3	0.000	0.333	Up	4.44e-01	4.79e-01	3.92e-01	4.19e-01
GO:0010035	3	0.000	0.000	Up	4.45e-01	4.79e-01	5.26e-01	5.49e-01
GO:0009234	2	0.000	0.000	Up	4.45e-01	4.79e-01	4.21e-01	4.47e-01
GO:0007033	4	0.250	0.000	Down	4.45e-01	4.79e-01	1.27e-01	1.51e-01
GO:0006541	2	0.000	0.000	Down	4.46e-01	4.79e-01	4.22e-01	4.47e-01
GO:0009233	2	0.000	0.000	Up	4.49e-01	4.82e-01	4.28e-01	4.53e-01
GO:0006888	20	0.150	0.150	Down	4.50e-01	4.82e-01	7.38e-02	9.48e-02
GO:0009071	3	0.000	0.333	Up	4.53e-01	4.85e-01	3.95e-01	4.21e-01
GO:0006424	3	0.000	0.000	Up	4.59e-01	4.91e-01	2.71e-01	3.02e-01
GO:0009219	2	0.000	0.000	Up	4.62e-01	4.94e-01	4.64e-01	4.90e-01
GO:0006787	2	0.000	0.000	Down	4.67e-01	4.98e-01	5.06e-01	5.30e-01
GO:0097428	1	0.000	0.000	Down	4.69e-01	5.00e-01	4.69e-01	4.94e-01
GO:0048856	4	0.000	0.250	Up	4.76e-01	5.07e-01	3.66e-01	3.95e-01
GO:0006885	8	0.125	0.125	Down	4.77e-01	5.08e-01	1.56e-01	1.84e-01
GO:0033015	2	0.000	0.000	Down	4.78e-01	5.08e-01	5.16e-01	5.39e-01
GO:0055067	8	0.125	0.125	Down	4.89e-01	5.19e-01	1.58e-01	1.86e-01
GO:0016197	3	0.000	0.000	Down	4.97e-01	5.27e-01	4.03e-01	4.28e-01
GO:0006891	3	0.000	0.000	Up	4.98e-01	5.27e-01	3.96e-01	4.22e-01
GO:0042147	3	0.000	0.000	Down	5.04e-01	5.34e-01	4.01e-01	4.27e-01
GO:0000280	14	0.071	0.071	Up	5.05e-01	5.34e-01	3.36e-01	3.66e-01
GO:0048285	14	0.071	0.071	Up	5.14e-01	5.43e-01	3.41e-01	3.70e-01
GO:0015908	3	0.333	0.000	Up	5.19e-01	5.48e-01	2.69e-01	3.01e-01
GO:0000290	3	0.000	0.000	Down	5.34e-01	5.63e-01	6.44e-01	6.61e-01
GO:0000288	3	0.000	0.000	Down	5.35e-01	5.63e-01	6.48e-01	6.63e-01
GO:0006308	4	0.250	0.000	Up	5.51e-01	5.79e-01	1.77e-01	2.06e-01
GO:0000724	2	0.000	0.000	Down	5.65e-01	5.93e-01	5.40e-01	5.59e-01
GO:0000725	2	0.000	0.000	Down	5.71e-01	5.99e-01	5.43e-01	5.61e-01
GO:0042255	11	0.091	0.091	Down	5.80e-01	6.08e-01	3.27e-01	3.58e-01
GO:0008283	3	0.000	0.000	Up	5.81e-01	6.09e-01	4.72e-01	4.97e-01
GO:0000070	2	0.000	0.000	Down	5.99e-01	6.26e-01	7.90e-01	7.99e-01
GO:0000387	4	0.250	0.000	Down	6.00e-01	6.27e-01	6.00e-01	6.18e-01
GO:0000819	2	0.000	0.000	Down	6.18e-01	6.44e-01	8.04e-01	8.11e-01
GO:0022603	2	0.000	0.000	Up	6.19e-01	6.45e-01	3.95e-01	4.21e-01
GO:0051452	7	0.000	0.143	Up	6.45e-01	6.71e-01	3.24e-01	3.56e-01
GO:0045851	7	0.000	0.143	Up	6.47e-01	6.72e-01	3.25e-01	3.56e-01
GO:0030641	7	0.000	0.143	Up	6.50e-01	6.75e-01	3.32e-01	3.62e-01
GO:0030004	7	0.000	0.143	Up	6.50e-01	6.75e-01	3.30e-01	3.61e-01
GO:0051453	7	0.000	0.143	Up	6.53e-01	6.77e-01	3.36e-01	3.66e-01
GO:0007035	7	0.000	0.143	Up	6.55e-01	6.79e-01	3.27e-01	3.58e-01
GO:0022900	7	0.143	0.143	Up	6.80e-01	7.03e-01	3.88e-01	4.15e-01
GO:0022904	6	0.167	0.167	Up	6.82e-01	7.04e-01	2.79e-01	3.10e-01
GO:0006865	4	0.000	0.000	Up	6.82e-01	7.04e-01	6.48e-01	6.63e-01
GO:0009225	4	0.000	0.000	Up	6.93e-01	7.14e-01	4.49e-01	4.74e-01
GO:0034637	3	0.000	0.000	Down	7.05e-01	7.24e-01	6.05e-01	6.22e-01
GO:0019673	3	0.000	0.000	Down	7.05e-01	7.24e-01	6.06e-01	6.22e-01
GO:0016114	2	0.000	0.000	Down	7.06e-01	7.24e-01	6.45e-01	6.62e-01
GO:0000304	2	0.000	0.000	Up	7.06e-01	7.24e-01	6.51e-01	6.65e-01
GO:0009072	3	0.000	0.000	Up	7.07e-01	7.24e-01	8.02e-01	8.10e-01
GO:0009073	3	0.000	0.000	Up	7.07e-01	7.24e-01	8.03e-01	8.11e-01
GO:0006721	2	0.000	0.000	Down	7.13e-01	7.29e-01	6.49e-01	6.63e-01
GO:0006836	1	0.000	0.000	Down	7.18e-01	7.34e-01	6.62e-01	6.76e-01
GO:0051187	3	0.000	0.000	Down	7.37e-01	7.53e-01	4.78e-01	5.03e-01
GO:0051170	10	0.100	0.000	Down	7.45e-01	7.60e-01	5.42e-01	5.61e-01
GO:0044744	10	0.100	0.000	Down	7.47e-01	7.60e-01	5.37e-01	5.57e-01
GO:0034504	10	0.100	0.000	Down	7.47e-01	7.60e-01	5.43e-01	5.61e-01
GO:1902593	10	0.100	0.000	Down	7.48e-01	7.60e-01	5.38e-01	5.57e-01
GO:0006606	10	0.100	0.000	Down	7.49e-01	7.61e-01	5.45e-01	5.62e-01
GO:0000096	3	0.000	0.000	Down	7.68e-01	7.79e-01	5.29e-01	5.50e-01
GO:0060249	3	0.000	0.000	Down	7.91e-01	8.02e-01	8.30e-01	8.36e-01
GO:0000723	3	0.000	0.000	Down	7.99e-01	8.08e-01	8.33e-01	8.37e-01
GO:0032200	3	0.000	0.000	Down	8.00e-01	8.08e-01	8.33e-01	8.37e-01
GO:0006471	3	0.000	0.000	Up	8.00e-01	8.08e-01	8.34e-01	8.37e-01
GO:0031109	3	0.000	0.000	Up	8.03e-01	8.09e-01	7.11e-01	7.21e-01
GO:0007020	3	0.000	0.000	Up	8.03e-01	8.09e-01	7.14e-01	7.23e-01
GO:0046785	3	0.000	0.000	Up	8.07e-01	8.13e-01	7.15e-01	7.23e-01
GO:0009067	3	0.000	0.000	Down	8.64e-01	8.69e-01	9.18e-01	9.18e-01
GO:0042819	3	0.000	0.000	Up	8.77e-01	8.81e-01	6.96e-01	7.08e-01
GO:0042816	3	0.000	0.000	Up	8.82e-01	8.86e-01	6.95e-01	7.08e-01
GO:0008614	3	0.000	0.000	Up	8.83e-01	8.86e-01	6.98e-01	7.09e-01
GO:0009432	2	0.000	0.000	Down	9.21e-01	9.22e-01	8.52e-01	8.53e-01
GO:0072525	4	0.000	0.000	Down	9.21e-01	9.22e-01	8.34e-01	8.37e-01
GO:0006607	3	0.000	0.000	Down	9.26e-01	9.26e-01	8.40e-01	8.42e-01

Also test using limma’s camera

go_cam$PValue <- format(go_cam$PValue, scientific = TRUE, digits = 3)
go_cam$FDR <- format(go_cam$FDR, scientific = TRUE, digits = 3)
kable(go_cam)

	NGenes	Direction	PValue	FDR
GO:0016337	54	Down	9.71e-23	4.68e-20
GO:0098602	54	Down	9.71e-23	4.68e-20
GO:0007155	69	Down	1.93e-18	6.21e-16
GO:0009405	84	Down	6.74e-18	1.62e-15
GO:0020035	93	Down	5.91e-17	5.67e-15
GO:0044406	93	Down	5.91e-17	5.67e-15
GO:0034118	87	Down	9.47e-17	5.67e-15
GO:0020013	87	Down	9.47e-17	5.67e-15
GO:0030155	87	Down	9.47e-17	5.67e-15
GO:0034110	87	Down	9.47e-17	5.67e-15
GO:0022407	87	Down	9.47e-17	5.67e-15
GO:0009607	94	Down	1.15e-16	5.67e-15
GO:0051807	93	Down	1.18e-16	5.67e-15
GO:0051834	93	Down	1.18e-16	5.67e-15
GO:0051832	93	Down	1.18e-16	5.67e-15
GO:0043207	93	Down	1.18e-16	5.67e-15
GO:0051707	93	Down	1.18e-16	5.67e-15
GO:0052173	93	Down	1.18e-16	5.67e-15
GO:0052564	93	Down	1.18e-16	5.67e-15
GO:0051805	93	Down	1.18e-16	5.67e-15
GO:0044068	88	Down	1.50e-16	6.88e-15
GO:0051809	92	Down	1.74e-16	7.29e-15
GO:0020033	92	Down	1.74e-16	7.29e-15
GO:0044003	89	Down	3.52e-16	1.36e-14
GO:0051817	89	Down	3.52e-16	1.36e-14
GO:0009605	100	Down	7.96e-16	2.95e-14
GO:0035821	90	Down	1.27e-15	4.55e-14
GO:0022610	113	Down	1.99e-14	6.86e-13
GO:0051704	189	Down	3.04e-08	1.01e-06
GO:0044403	157	Down	1.04e-07	3.23e-06
GO:0044419	157	Down	1.04e-07	3.23e-06
GO:0065008	149	Down	1.23e-07	3.69e-06
GO:0051701	147	Down	1.97e-07	5.74e-06
GO:0050896	291	Down	7.09e-05	2.01e-03
GO:0006096	17	Down	2.70e-04	7.43e-03
GO:0044724	24	Down	3.80e-04	9.90e-03
GO:0016052	24	Down	3.80e-04	9.90e-03
GO:0006457	72	Down	4.29e-04	1.09e-02
GO:0019319	6	Down	2.54e-03	6.06e-02
GO:0046364	6	Down	2.54e-03	6.06e-02
GO:0050789	380	Down	2.58e-03	6.06e-02
GO:0006094	5	Down	2.74e-03	6.28e-02
GO:0044723	42	Down	3.60e-03	8.07e-02
GO:0050794	359	Down	4.64e-03	1.02e-01
GO:0070682	6	Down	5.41e-03	1.16e-01
GO:0065007	401	Down	6.25e-03	1.29e-01
GO:0016485	10	Down	6.38e-03	1.29e-01
GO:0006006	12	Down	6.45e-03	1.29e-01
GO:0019318	14	Down	6.69e-03	1.29e-01
GO:0005996	14	Down	6.69e-03	1.29e-01
GO:0016051	12	Down	9.52e-03	1.80e-01
GO:0005975	53	Down	1.03e-02	1.91e-01
GO:0016255	4	Up	1.06e-02	1.93e-01
GO:0051604	12	Down	1.18e-02	2.06e-01
GO:0006497	18	Up	1.22e-02	2.06e-01
GO:0042158	18	Up	1.22e-02	2.06e-01
GO:0042157	18	Up	1.22e-02	2.06e-01
GO:0031123	8	Up	1.50e-02	2.49e-01
GO:0007275	6	Up	1.54e-02	2.51e-01
GO:0006506	9	Up	1.62e-02	2.61e-01
GO:0042176	3	Down	1.65e-02	2.61e-01
GO:0042026	3	Down	1.69e-02	2.61e-01
GO:0000375	64	Down	1.74e-02	2.61e-01
GO:0001817	3	Down	1.79e-02	2.61e-01
GO:0051239	3	Down	1.79e-02	2.61e-01
GO:0009396	4	Down	1.80e-02	2.61e-01
GO:0031167	2	Down	1.81e-02	2.61e-01
GO:0006643	15	Up	1.84e-02	2.61e-01
GO:0051051	3	Up	2.04e-02	2.85e-01
GO:0044712	59	Down	2.10e-02	2.87e-01
GO:0008380	81	Down	2.12e-02	2.87e-01
GO:0046467	13	Up	2.20e-02	2.94e-01
GO:0000245	9	Down	2.22e-02	2.94e-01
GO:0006505	10	Up	2.26e-02	2.94e-01
GO:0051276	43	Down	2.35e-02	3.03e-01
GO:0022613	98	Down	2.42e-02	3.05e-01
GO:0044767	11	Up	2.44e-02	3.05e-01
GO:0006661	10	Up	2.85e-02	3.52e-01
GO:0032312	2	Up	2.91e-02	3.55e-01
GO:0071900	3	Up	3.02e-02	3.57e-01
GO:0000079	3	Up	3.02e-02	3.57e-01
GO:0044707	7	Up	3.04e-02	3.57e-01
GO:0035383	7	Up	3.11e-02	3.57e-01
GO:0006637	7	Up	3.11e-02	3.57e-01
GO:0009247	12	Up	3.20e-02	3.63e-01
GO:0016571	5	Down	3.24e-02	3.63e-01
GO:0000377	59	Down	3.44e-02	3.77e-01
GO:0000398	59	Down	3.44e-02	3.77e-01
GO:0008154	1	Down	3.55e-02	3.84e-01
GO:0009206	8	Up	3.63e-02	3.84e-01
GO:0009201	8	Up	3.63e-02	3.84e-01
GO:0022616	5	Up	3.77e-02	3.90e-01
GO:0006271	5	Up	3.77e-02	3.90e-01
GO:0051188	30	Up	3.84e-02	3.94e-01
GO:0006664	13	Up	3.94e-02	4.00e-01
GO:1901575	165	Down	4.23e-02	4.25e-01
GO:0009056	171	Down	4.31e-02	4.29e-01
GO:0032502	12	Up	4.58e-02	4.47e-01
GO:0006084	5	Up	4.59e-02	4.47e-01
GO:0043543	15	Up	4.91e-02	4.53e-01
GO:0031399	5	Up	5.04e-02	4.53e-01
GO:0001932	5	Up	5.04e-02	4.53e-01
GO:0042325	5	Up	5.04e-02	4.53e-01
GO:0000910	4	Up	5.07e-02	4.53e-01
GO:0071826	31	Down	5.20e-02	4.53e-01
GO:0032507	2	Up	5.29e-02	4.53e-01
GO:0051651	2	Up	5.29e-02	4.53e-01
GO:0071616	4	Up	5.39e-02	4.53e-01
GO:0006085	4	Up	5.39e-02	4.53e-01
GO:0006086	4	Up	5.39e-02	4.53e-01
GO:0035384	4	Up	5.39e-02	4.53e-01
GO:0006465	7	Down	5.45e-02	4.53e-01
GO:0046148	6	Up	5.54e-02	4.53e-01
GO:0033014	6	Up	5.54e-02	4.53e-01
GO:0006783	6	Up	5.54e-02	4.53e-01
GO:0006779	6	Up	5.54e-02	4.53e-01
GO:0071840	251	Down	5.54e-02	4.53e-01
GO:0002098	4	Up	5.60e-02	4.53e-01
GO:0002097	4	Up	5.60e-02	4.53e-01
GO:0006206	6	Down	5.74e-02	4.61e-01
GO:0044085	153	Down	6.23e-02	4.91e-01
GO:0032501	8	Up	6.24e-02	4.91e-01
GO:0006511	71	Down	6.47e-02	4.91e-01
GO:0009152	17	Up	6.53e-02	4.91e-01
GO:0006098	9	Down	6.67e-02	4.91e-01
GO:0046365	9	Down	6.67e-02	4.91e-01
GO:0006740	9	Down	6.67e-02	4.91e-01
GO:0006007	9	Down	6.67e-02	4.91e-01
GO:0006739	9	Down	6.67e-02	4.91e-01
GO:0019320	9	Down	6.67e-02	4.91e-01
GO:0030154	7	Up	6.69e-02	4.91e-01
GO:0018394	4	Up	6.91e-02	4.91e-01
GO:0006475	4	Up	6.91e-02	4.91e-01
GO:0018393	4	Up	6.91e-02	4.91e-01
GO:0016573	4	Up	6.91e-02	4.91e-01
GO:0032784	3	Down	6.96e-02	4.91e-01
GO:0019362	10	Down	7.02e-02	4.91e-01
GO:0046496	10	Down	7.02e-02	4.91e-01
GO:0043933	107	Down	7.11e-02	4.93e-01
GO:0006090	24	Down	7.24e-02	4.98e-01
GO:0022618	29	Down	7.30e-02	4.99e-01
GO:0009628	22	Down	7.36e-02	5.00e-01
GO:0010608	25	Down	7.79e-02	5.23e-01
GO:0042254	80	Down	7.84e-02	5.23e-01
GO:0045017	17	Up	7.87e-02	5.23e-01
GO:0031338	14	Up	8.21e-02	5.31e-01
GO:0006890	6	Up	8.25e-02	5.31e-01
GO:0019941	73	Down	8.29e-02	5.31e-01
GO:0043632	73	Down	8.29e-02	5.31e-01
GO:0009060	17	Up	8.51e-02	5.31e-01
GO:0006099	17	Up	8.51e-02	5.31e-01
GO:0006813	4	Up	8.61e-02	5.31e-01
GO:0051603	76	Down	8.70e-02	5.31e-01
GO:0044257	76	Down	8.70e-02	5.31e-01
GO:0045859	4	Up	8.71e-02	5.31e-01
GO:0051338	4	Up	8.71e-02	5.31e-01
GO:0043549	4	Up	8.71e-02	5.31e-01
GO:1901607	11	Down	8.71e-02	5.31e-01
GO:0000154	5	Down	8.85e-02	5.31e-01
GO:0044743	6	Down	8.90e-02	5.31e-01
GO:0043248	8	Down	8.97e-02	5.31e-01
GO:0042493	51	Down	9.02e-02	5.31e-01
GO:0007005	14	Down	9.28e-02	5.31e-01
GO:0072655	14	Down	9.28e-02	5.31e-01
GO:0070585	14	Down	9.28e-02	5.31e-01
GO:0006626	14	Down	9.28e-02	5.31e-01
GO:0044272	14	Up	9.45e-02	5.31e-01
GO:0018345	8	Up	9.52e-02	5.31e-01
GO:0006760	5	Down	9.58e-02	5.31e-01
GO:0048518	11	Down	9.62e-02	5.31e-01
GO:0006338	4	Down	9.62e-02	5.31e-01
GO:0043631	6	Up	9.75e-02	5.31e-01
GO:0009260	18	Up	9.81e-02	5.31e-01
GO:0051301	23	Up	9.86e-02	5.31e-01
GO:0034622	64	Down	9.93e-02	5.31e-01
GO:0006473	6	Up	9.94e-02	5.31e-01
GO:0009890	5	Down	9.97e-02	5.31e-01
GO:0031327	5	Down	9.97e-02	5.31e-01
GO:0006166	2	Down	1.00e-01	5.31e-01
GO:0043101	2	Down	1.00e-01	5.31e-01
GO:0043174	2	Down	1.00e-01	5.31e-01
GO:0006848	2	Down	1.00e-01	5.31e-01
GO:0097354	6	Up	1.03e-01	5.35e-01
GO:0018342	6	Up	1.03e-01	5.35e-01
GO:0009266	21	Down	1.03e-01	5.35e-01
GO:0046474	16	Up	1.04e-01	5.35e-01
GO:0006414	20	Down	1.04e-01	5.35e-01
GO:0016043	183	Down	1.04e-01	5.35e-01
GO:0006066	7	Down	1.05e-01	5.36e-01
GO:0046390	19	Up	1.06e-01	5.39e-01
GO:0034968	4	Down	1.10e-01	5.52e-01
GO:0006754	7	Up	1.12e-01	5.52e-01
GO:0015985	7	Up	1.12e-01	5.52e-01
GO:0015986	7	Up	1.12e-01	5.52e-01
GO:0006325	29	Down	1.12e-01	5.52e-01
GO:0043241	6	Up	1.12e-01	5.52e-01
GO:1901137	55	Up	1.13e-01	5.52e-01
GO:0042594	3	Down	1.13e-01	5.52e-01
GO:0008033	37	Up	1.16e-01	5.62e-01
GO:0000278	13	Up	1.21e-01	5.71e-01
GO:0009112	7	Down	1.22e-01	5.71e-01
GO:0015980	24	Up	1.23e-01	5.71e-01
GO:2000113	4	Down	1.24e-01	5.71e-01
GO:0010558	4	Down	1.24e-01	5.71e-01
GO:0045892	4	Down	1.24e-01	5.71e-01
GO:1902679	4	Down	1.24e-01	5.71e-01
GO:0051253	4	Down	1.24e-01	5.71e-01
GO:0051172	4	Down	1.24e-01	5.71e-01
GO:0045934	4	Down	1.24e-01	5.71e-01
GO:0048869	8	Up	1.25e-01	5.72e-01
GO:0042221	68	Down	1.26e-01	5.75e-01
GO:0006790	20	Up	1.27e-01	5.77e-01
GO:0009145	9	Up	1.29e-01	5.78e-01
GO:0090151	3	Down	1.30e-01	5.78e-01
GO:0007007	3	Down	1.30e-01	5.78e-01
GO:0045039	3	Down	1.30e-01	5.78e-01
GO:0007006	3	Down	1.30e-01	5.78e-01
GO:0009147	3	Up	1.32e-01	5.78e-01
GO:0006730	4	Down	1.32e-01	5.78e-01
GO:0006164	19	Up	1.32e-01	5.78e-01
GO:0007049	36	Up	1.33e-01	5.78e-01
GO:0019856	5	Down	1.35e-01	5.78e-01
GO:0006207	5	Down	1.35e-01	5.78e-01
GO:0046112	5	Down	1.35e-01	5.78e-01
GO:1902580	33	Down	1.36e-01	5.78e-01
GO:0043094	3	Down	1.38e-01	5.78e-01
GO:0034982	2	Down	1.38e-01	5.78e-01
GO:0007059	8	Up	1.38e-01	5.78e-01
GO:0072524	12	Down	1.38e-01	5.78e-01
GO:0006417	22	Down	1.38e-01	5.78e-01
GO:0009108	24	Up	1.39e-01	5.79e-01
GO:0006518	11	Down	1.40e-01	5.81e-01
GO:0006379	4	Up	1.40e-01	5.81e-01
GO:0044265	97	Down	1.42e-01	5.81e-01
GO:0045333	23	Up	1.42e-01	5.81e-01
GO:0035890	12	Up	1.46e-01	5.96e-01
GO:0006875	4	Up	1.47e-01	5.96e-01
GO:0055065	4	Up	1.47e-01	5.96e-01
GO:0006839	18	Down	1.48e-01	5.96e-01
GO:0009142	10	Up	1.49e-01	5.96e-01
GO:0072594	32	Down	1.49e-01	5.96e-01
GO:0009408	20	Down	1.50e-01	5.96e-01
GO:0065002	11	Down	1.51e-01	5.98e-01
GO:0018344	3	Up	1.53e-01	6.02e-01
GO:0006605	34	Down	1.53e-01	6.02e-01
GO:0065003	74	Down	1.54e-01	6.02e-01
GO:0008535	1	Up	1.55e-01	6.05e-01
GO:0007015	4	Down	1.56e-01	6.05e-01
GO:0006996	110	Down	1.57e-01	6.06e-01
GO:0043648	10	Down	1.58e-01	6.09e-01
GO:0046129	17	Up	1.59e-01	6.09e-01
GO:0042451	17	Up	1.59e-01	6.09e-01
GO:1903047	12	Up	1.60e-01	6.10e-01
GO:0090150	11	Down	1.62e-01	6.12e-01
GO:0072657	11	Down	1.62e-01	6.12e-01
GO:0006378	5	Up	1.67e-01	6.22e-01
GO:0031124	5	Up	1.67e-01	6.22e-01
GO:0009452	6	Down	1.69e-01	6.22e-01
GO:0036260	6	Down	1.69e-01	6.22e-01
GO:0033013	8	Up	1.70e-01	6.22e-01
GO:0042440	8	Up	1.70e-01	6.22e-01
GO:0042168	8	Up	1.70e-01	6.22e-01
GO:0006778	8	Up	1.70e-01	6.22e-01
GO:0009057	101	Down	1.71e-01	6.26e-01
GO:0010629	6	Down	1.76e-01	6.42e-01
GO:0006410	5	Up	1.78e-01	6.43e-01
GO:0008643	4	Up	1.80e-01	6.43e-01
GO:0000394	2	Up	1.83e-01	6.43e-01
GO:0006388	2	Up	1.83e-01	6.43e-01
GO:0046165	6	Down	1.84e-01	6.43e-01
GO:0043603	15	Down	1.85e-01	6.43e-01
GO:0016482	66	Down	1.85e-01	6.43e-01
GO:0006665	2	Up	1.85e-01	6.43e-01
GO:0006817	22	Down	1.87e-01	6.43e-01
GO:0051258	8	Up	1.88e-01	6.43e-01
GO:0051130	3	Down	1.88e-01	6.43e-01
GO:0042777	1	Up	1.89e-01	6.43e-01
GO:0051246	31	Down	1.89e-01	6.43e-01
GO:0071496	5	Down	1.91e-01	6.43e-01
GO:0031668	5	Down	1.91e-01	6.43e-01
GO:0015937	4	Up	1.93e-01	6.43e-01
GO:0033866	4	Up	1.93e-01	6.43e-01
GO:0034032	4	Up	1.93e-01	6.43e-01
GO:0034033	4	Up	1.93e-01	6.43e-01
GO:0033875	4	Up	1.93e-01	6.43e-01
GO:0015936	4	Up	1.93e-01	6.43e-01
GO:0033865	4	Up	1.93e-01	6.43e-01
GO:0034030	4	Up	1.93e-01	6.43e-01
GO:0016568	18	Down	1.93e-01	6.43e-01
GO:0042181	6	Up	1.97e-01	6.44e-01
GO:1901661	6	Up	1.97e-01	6.44e-01
GO:0042180	6	Up	1.97e-01	6.44e-01
GO:1901663	6	Up	1.97e-01	6.44e-01
GO:0035891	11	Up	1.97e-01	6.44e-01
GO:0006364	48	Down	1.98e-01	6.44e-01
GO:0016072	48	Down	1.98e-01	6.44e-01
GO:0043484	2	Down	1.99e-01	6.44e-01
GO:0015074	3	Down	2.00e-01	6.44e-01
GO:0009148	2	Up	2.00e-01	6.44e-01
GO:0051235	3	Up	2.01e-01	6.44e-01
GO:0045185	3	Up	2.01e-01	6.44e-01
GO:0044248	137	Down	2.08e-01	6.55e-01
GO:0032269	1	Up	2.08e-01	6.55e-01
GO:0051248	1	Up	2.08e-01	6.55e-01
GO:0000413	10	Down	2.09e-01	6.55e-01
GO:0018208	10	Down	2.09e-01	6.55e-01
GO:0030163	86	Down	2.09e-01	6.55e-01
GO:0010256	4	Up	2.10e-01	6.55e-01
GO:0043624	5	Up	2.11e-01	6.55e-01
GO:0006415	5	Up	2.11e-01	6.55e-01
GO:0022607	83	Down	2.11e-01	6.55e-01
GO:0006260	47	Up	2.16e-01	6.67e-01
GO:0042273	16	Down	2.16e-01	6.67e-01
GO:0009127	11	Up	2.18e-01	6.69e-01
GO:0009168	11	Up	2.18e-01	6.69e-01
GO:1901615	13	Down	2.20e-01	6.71e-01
GO:0010564	17	Up	2.23e-01	6.79e-01
GO:0033365	33	Down	2.24e-01	6.79e-01
GO:0008610	53	Up	2.26e-01	6.79e-01
GO:0016071	100	Down	2.26e-01	6.79e-01
GO:0019752	129	Down	2.26e-01	6.79e-01
GO:0000003	3	Down	2.30e-01	6.86e-01
GO:0006986	12	Down	2.31e-01	6.86e-01
GO:0035966	12	Down	2.31e-01	6.86e-01
GO:0019751	3	Down	2.31e-01	6.86e-01
GO:0009132	5	Up	2.34e-01	6.91e-01
GO:0071976	4	Up	2.37e-01	6.98e-01
GO:0000956	5	Down	2.39e-01	6.98e-01
GO:0043436	130	Down	2.39e-01	6.98e-01
GO:0006082	130	Down	2.39e-01	6.98e-01
GO:0006520	75	Down	2.40e-01	6.98e-01
GO:0043650	3	Down	2.42e-01	6.99e-01
GO:0015693	1	Up	2.42e-01	6.99e-01
GO:0071806	16	Down	2.42e-01	6.99e-01
GO:0051186	45	Up	2.46e-01	7.01e-01
GO:0033043	19	Up	2.46e-01	7.01e-01
GO:0070646	11	Down	2.46e-01	7.01e-01
GO:0016579	11	Down	2.46e-01	7.01e-01
GO:1901264	5	Up	2.47e-01	7.01e-01
GO:0051049	27	Up	2.49e-01	7.03e-01
GO:0032879	27	Up	2.49e-01	7.03e-01
GO:0034227	3	Up	2.51e-01	7.04e-01
GO:0022402	21	Up	2.52e-01	7.04e-01
GO:0042439	4	Down	2.53e-01	7.04e-01
GO:0046470	4	Down	2.53e-01	7.04e-01
GO:0006656	4	Down	2.53e-01	7.04e-01
GO:0006367	8	Up	2.54e-01	7.04e-01
GO:0006091	41	Down	2.54e-01	7.04e-01
GO:0071103	19	Down	2.55e-01	7.04e-01
GO:0031365	4	Down	2.61e-01	7.17e-01
GO:0006275	3	Up	2.61e-01	7.17e-01
GO:0010033	13	Down	2.65e-01	7.25e-01
GO:0015698	23	Down	2.66e-01	7.25e-01
GO:0015858	3	Up	2.72e-01	7.37e-01
GO:0006487	2	Up	2.73e-01	7.37e-01
GO:0006820	41	Down	2.74e-01	7.37e-01
GO:0010467	524	Down	2.75e-01	7.37e-01
GO:0007186	4	Up	2.77e-01	7.37e-01
GO:0002682	6	Down	2.80e-01	7.37e-01
GO:0050776	6	Down	2.80e-01	7.37e-01
GO:0070085	7	Up	2.80e-01	7.37e-01
GO:0006486	7	Up	2.80e-01	7.37e-01
GO:0009100	7	Up	2.80e-01	7.37e-01
GO:0009101	7	Up	2.80e-01	7.37e-01
GO:0043413	7	Up	2.80e-01	7.37e-01
GO:0008616	4	Down	2.81e-01	7.37e-01
GO:0046116	4	Down	2.81e-01	7.37e-01
GO:0070647	29	Down	2.82e-01	7.40e-01
GO:0015914	4	Down	2.86e-01	7.46e-01
GO:0019220	27	Up	2.95e-01	7.61e-01
GO:0051174	27	Up	2.95e-01	7.61e-01
GO:0006397	93	Down	2.95e-01	7.61e-01
GO:0007067	11	Up	2.95e-01	7.61e-01
GO:0030029	10	Down	2.96e-01	7.61e-01
GO:0071824	11	Down	2.97e-01	7.61e-01
GO:0065004	11	Down	2.97e-01	7.61e-01
GO:1901605	24	Down	3.01e-01	7.61e-01
GO:0006743	5	Up	3.02e-01	7.61e-01
GO:0006744	5	Up	3.02e-01	7.61e-01
GO:0072522	22	Up	3.05e-01	7.61e-01
GO:0050658	7	Down	3.06e-01	7.61e-01
GO:0051236	7	Down	3.06e-01	7.61e-01
GO:0006403	7	Down	3.06e-01	7.61e-01
GO:0050657	7	Down	3.06e-01	7.61e-01
GO:0006281	50	Up	3.06e-01	7.61e-01
GO:0006081	6	Up	3.07e-01	7.61e-01
GO:0001522	17	Up	3.08e-01	7.61e-01
GO:0030001	16	Up	3.08e-01	7.61e-01
GO:0006118	4	Up	3.10e-01	7.61e-01
GO:0009124	12	Up	3.12e-01	7.61e-01
GO:0009156	12	Up	3.12e-01	7.61e-01
GO:0010468	116	Down	3.13e-01	7.61e-01
GO:0006767	8	Up	3.13e-01	7.61e-01
GO:0006766	8	Up	3.13e-01	7.61e-01
GO:0042364	8	Up	3.13e-01	7.61e-01
GO:0009110	8	Up	3.13e-01	7.61e-01
GO:0006873	11	Up	3.14e-01	7.61e-01
GO:0030003	11	Up	3.14e-01	7.61e-01
GO:0044267	562	Down	3.16e-01	7.62e-01
GO:0008654	25	Up	3.16e-01	7.62e-01
GO:0031324	6	Down	3.20e-01	7.69e-01
GO:0044262	11	Down	3.23e-01	7.74e-01
GO:0006631	29	Up	3.25e-01	7.74e-01
GO:0030488	4	Up	3.25e-01	7.74e-01
GO:0009991	7	Down	3.25e-01	7.74e-01
GO:0044699	809	Down	3.27e-01	7.77e-01
GO:0006420	3	Up	3.29e-01	7.79e-01
GO:0060255	128	Down	3.30e-01	7.80e-01
GO:0072330	21	Up	3.34e-01	7.86e-01
GO:0000350	3	Down	3.35e-01	7.86e-01
GO:0051169	25	Down	3.37e-01	7.86e-01
GO:0006913	25	Down	3.37e-01	7.86e-01
GO:0006575	13	Down	3.38e-01	7.86e-01
GO:0032012	3	Up	3.39e-01	7.86e-01
GO:0030433	19	Up	3.42e-01	7.86e-01
GO:0043412	249	Up	3.42e-01	7.86e-01
GO:0006468	91	Up	3.44e-01	7.86e-01
GO:0048523	10	Down	3.44e-01	7.86e-01
GO:0009892	8	Down	3.45e-01	7.86e-01
GO:0046034	12	Up	3.46e-01	7.86e-01
GO:0006629	86	Up	3.46e-01	7.86e-01
GO:0042559	6	Down	3.47e-01	7.86e-01
GO:0009451	43	Up	3.47e-01	7.86e-01
GO:0020027	7	Up	3.47e-01	7.86e-01
GO:0042540	7	Up	3.47e-01	7.86e-01
GO:0042398	11	Down	3.49e-01	7.86e-01
GO:0040011	58	Up	3.49e-01	7.86e-01
GO:1901617	9	Down	3.49e-01	7.86e-01
GO:0000226	5	Up	3.51e-01	7.88e-01
GO:0006396	207	Down	3.53e-01	7.90e-01
GO:0006401	10	Down	3.54e-01	7.90e-01
GO:0030150	3	Down	3.54e-01	7.90e-01
GO:0006508	138	Down	3.55e-01	7.90e-01
GO:0002376	7	Down	3.58e-01	7.95e-01
GO:0006544	4	Up	3.64e-01	7.95e-01
GO:0006974	51	Up	3.67e-01	7.95e-01
GO:0051128	22	Up	3.70e-01	7.95e-01
GO:0044238	1268	Down	3.71e-01	7.95e-01
GO:0006979	10	Down	3.75e-01	7.95e-01
GO:0032984	8	Up	3.77e-01	7.95e-01
GO:0022411	8	Up	3.77e-01	7.95e-01
GO:0006825	3	Up	3.79e-01	7.95e-01
GO:1901564	179	Down	3.79e-01	7.95e-01
GO:0046395	7	Up	3.81e-01	7.95e-01
GO:0044282	7	Up	3.81e-01	7.95e-01
GO:0016054	7	Up	3.81e-01	7.95e-01
GO:0006733	15	Down	3.81e-01	7.95e-01
GO:0044260	985	Down	3.82e-01	7.95e-01
GO:0044106	8	Down	3.83e-01	7.95e-01
GO:0009308	8	Down	3.83e-01	7.95e-01
GO:0006576	8	Down	3.83e-01	7.95e-01
GO:0043086	3	Down	3.83e-01	7.95e-01
GO:0044092	3	Down	3.83e-01	7.95e-01
GO:0008213	8	Down	3.86e-01	7.95e-01
GO:0006479	8	Down	3.86e-01	7.95e-01
GO:0044417	4	Up	3.86e-01	7.95e-01
GO:0042000	4	Up	3.86e-01	7.95e-01
GO:0051836	4	Up	3.86e-01	7.95e-01
GO:0044766	4	Up	3.86e-01	7.95e-01
GO:1902579	4	Up	3.86e-01	7.95e-01
GO:0051808	4	Up	3.86e-01	7.95e-01
GO:0044053	4	Up	3.86e-01	7.95e-01
GO:0010638	2	Down	3.86e-01	7.95e-01
GO:0031334	2	Down	3.86e-01	7.95e-01
GO:0051495	2	Down	3.86e-01	7.95e-01
GO:0030838	2	Down	3.86e-01	7.95e-01
GO:0032273	2	Down	3.86e-01	7.95e-01
GO:0045010	2	Down	3.86e-01	7.95e-01
GO:0019222	152	Down	3.88e-01	7.95e-01
GO:0006750	3	Up	3.89e-01	7.95e-01
GO:0019184	3	Up	3.89e-01	7.95e-01
GO:0043043	3	Up	3.89e-01	7.95e-01
GO:0044281	231	Down	3.91e-01	7.96e-01
GO:0030261	2	Down	3.92e-01	7.96e-01
GO:0006402	7	Down	3.93e-01	7.96e-01
GO:0051260	3	Down	3.93e-01	7.96e-01
GO:0019538	628	Down	4.00e-01	7.97e-01
GO:1901135	97	Up	4.00e-01	7.97e-01
GO:0046131	2	Up	4.00e-01	7.97e-01
GO:0009218	2	Up	4.00e-01	7.97e-01
GO:0009220	2	Up	4.00e-01	7.97e-01
GO:0046132	2	Up	4.00e-01	7.97e-01
GO:0046134	2	Up	4.00e-01	7.97e-01
GO:0006213	2	Up	4.00e-01	7.97e-01
GO:0019439	37	Down	4.01e-01	7.97e-01
GO:0006633	19	Up	4.03e-01	7.99e-01
GO:0043087	18	Up	4.06e-01	8.00e-01
GO:0033124	18	Up	4.06e-01	8.00e-01
GO:1901070	2	Up	4.07e-01	8.00e-01
GO:0055086	85	Down	4.07e-01	8.00e-01
GO:0006897	7	Down	4.08e-01	8.00e-01
GO:0044255	73	Up	4.11e-01	8.05e-01
GO:0006357	10	Down	4.14e-01	8.07e-01
GO:0006400	19	Up	4.15e-01	8.07e-01
GO:0046700	39	Down	4.17e-01	8.07e-01
GO:0044270	39	Down	4.17e-01	8.07e-01
GO:1901361	39	Down	4.17e-01	8.07e-01
GO:0006366	21	Up	4.17e-01	8.07e-01
GO:0055082	12	Up	4.20e-01	8.08e-01
GO:0043038	40	Down	4.20e-01	8.08e-01
GO:0043039	40	Down	4.20e-01	8.08e-01
GO:0044237	1238	Down	4.25e-01	8.16e-01
GO:0009438	2	Up	4.26e-01	8.16e-01
GO:0032508	6	Down	4.28e-01	8.17e-01
GO:0032392	6	Down	4.28e-01	8.17e-01
GO:0010605	7	Down	4.33e-01	8.24e-01
GO:0016310	99	Up	4.34e-01	8.24e-01
GO:0043170	1043	Down	4.35e-01	8.24e-01
GO:0071897	1	Up	4.35e-01	8.24e-01
GO:0006265	3	Down	4.38e-01	8.28e-01
GO:0006434	3	Down	4.44e-01	8.37e-01
GO:0009084	3	Down	4.48e-01	8.40e-01
GO:0048878	14	Up	4.50e-01	8.40e-01
GO:0034655	35	Down	4.51e-01	8.40e-01
GO:1901700	3	Up	4.55e-01	8.40e-01
GO:0010035	3	Up	4.55e-01	8.40e-01
GO:0000302	3	Up	4.55e-01	8.40e-01
GO:0006732	37	Up	4.56e-01	8.40e-01
GO:0006412	231	Down	4.57e-01	8.40e-01
GO:0051806	42	Up	4.57e-01	8.40e-01
GO:0030260	42	Up	4.57e-01	8.40e-01
GO:0036211	206	Up	4.58e-01	8.40e-01
GO:0006464	206	Up	4.58e-01	8.40e-01
GO:0052192	54	Up	4.61e-01	8.40e-01
GO:0052126	54	Up	4.61e-01	8.40e-01
GO:0009066	4	Down	4.61e-01	8.40e-01
GO:0006298	8	Up	4.61e-01	8.40e-01
GO:0015749	2	Up	4.61e-01	8.40e-01
GO:0008645	2	Up	4.61e-01	8.40e-01
GO:0051726	29	Up	4.65e-01	8.42e-01
GO:0006269	2	Up	4.69e-01	8.42e-01
GO:0071704	1299	Down	4.70e-01	8.42e-01
GO:0000027	8	Down	4.74e-01	8.42e-01
GO:0048193	26	Up	4.75e-01	8.42e-01
GO:0006261	27	Up	4.75e-01	8.42e-01
GO:0009263	4	Up	4.76e-01	8.42e-01
GO:0009987	1474	Down	4.78e-01	8.42e-01
GO:0031326	111	Down	4.78e-01	8.42e-01
GO:0009889	111	Down	4.78e-01	8.42e-01
GO:0016070	365	Down	4.80e-01	8.42e-01
GO:0051674	10	Up	4.83e-01	8.42e-01
GO:0048870	10	Up	4.83e-01	8.42e-01
GO:0090407	64	Up	4.83e-01	8.42e-01
GO:0032787	53	Down	4.87e-01	8.42e-01
GO:0032318	15	Up	4.89e-01	8.42e-01
GO:0080090	141	Down	4.92e-01	8.42e-01
GO:0048522	8	Down	4.98e-01	8.42e-01
GO:0050790	27	Up	4.99e-01	8.42e-01
GO:0065009	27	Up	4.99e-01	8.42e-01
GO:0008652	20	Down	4.99e-01	8.42e-01
GO:0033036	161	Down	4.99e-01	8.42e-01
GO:0030036	8	Down	5.00e-01	8.42e-01
GO:0060627	23	Up	5.00e-01	8.42e-01
GO:0009163	22	Up	5.02e-01	8.42e-01
GO:0042455	22	Up	5.02e-01	8.42e-01
GO:0010556	110	Down	5.02e-01	8.42e-01
GO:2000112	110	Down	5.02e-01	8.42e-01
GO:0006413	48	Down	5.03e-01	8.42e-01
GO:1901565	31	Down	5.06e-01	8.42e-01
GO:0009167	17	Up	5.07e-01	8.42e-01
GO:0009126	17	Up	5.07e-01	8.42e-01
GO:0009150	40	Up	5.09e-01	8.42e-01
GO:0016226	4	Up	5.09e-01	8.42e-01
GO:0031163	4	Up	5.09e-01	8.42e-01
GO:0015672	24	Up	5.13e-01	8.42e-01
GO:0061024	17	Down	5.15e-01	8.42e-01
GO:0006536	5	Down	5.16e-01	8.42e-01
GO:0006826	3	Down	5.16e-01	8.42e-01
GO:0015684	3	Down	5.16e-01	8.42e-01
GO:1901136	23	Down	5.17e-01	8.42e-01
GO:0017038	19	Down	5.19e-01	8.42e-01
GO:0006284	4	Down	5.20e-01	8.42e-01
GO:0007169	3	Up	5.20e-01	8.42e-01
GO:0007167	3	Up	5.20e-01	8.42e-01
GO:0006352	14	Up	5.21e-01	8.42e-01
GO:0098662	17	Up	5.22e-01	8.42e-01
GO:0098655	17	Up	5.22e-01	8.42e-01
GO:0098660	17	Up	5.22e-01	8.42e-01
GO:0006268	2	Down	5.31e-01	8.42e-01
GO:0007018	19	Down	5.31e-01	8.42e-01
GO:0045047	7	Down	5.32e-01	8.42e-01
GO:0072599	7	Down	5.32e-01	8.42e-01
GO:0006612	7	Down	5.32e-01	8.42e-01
GO:0072523	19	Down	5.32e-01	8.42e-01
GO:0009164	19	Down	5.32e-01	8.42e-01
GO:1901658	19	Down	5.32e-01	8.42e-01
GO:0042454	19	Down	5.32e-01	8.42e-01
GO:0006152	19	Down	5.32e-01	8.42e-01
GO:0046130	19	Down	5.32e-01	8.42e-01
GO:0055076	3	Up	5.32e-01	8.42e-01
GO:0046916	3	Up	5.32e-01	8.42e-01
GO:0044087	5	Down	5.33e-01	8.42e-01
GO:0030833	5	Down	5.33e-01	8.42e-01
GO:0032535	5	Down	5.33e-01	8.42e-01
GO:0043254	5	Down	5.33e-01	8.42e-01
GO:0090066	5	Down	5.33e-01	8.42e-01
GO:0032271	5	Down	5.33e-01	8.42e-01
GO:0032970	5	Down	5.33e-01	8.42e-01
GO:0008064	5	Down	5.33e-01	8.42e-01
GO:0032956	5	Down	5.33e-01	8.42e-01
GO:0051493	5	Down	5.33e-01	8.42e-01
GO:0030832	5	Down	5.33e-01	8.42e-01
GO:0090305	10	Up	5.33e-01	8.42e-01
GO:0051028	4	Down	5.33e-01	8.42e-01
GO:0006886	102	Down	5.35e-01	8.42e-01
GO:0031667	4	Down	5.35e-01	8.42e-01
GO:0016567	11	Down	5.36e-01	8.42e-01
GO:0070925	15	Down	5.36e-01	8.42e-01
GO:0042775	2	Up	5.36e-01	8.42e-01
GO:0006122	2	Up	5.36e-01	8.42e-01
GO:0006323	10	Down	5.37e-01	8.42e-01
GO:0034641	602	Down	5.38e-01	8.42e-01
GO:0006259	120	Up	5.38e-01	8.42e-01
GO:0033554	55	Up	5.40e-01	8.42e-01
GO:0043161	21	Up	5.40e-01	8.42e-01
GO:0010498	21	Up	5.40e-01	8.42e-01
GO:0008152	1383	Down	5.41e-01	8.42e-01
GO:0050801	12	Up	5.46e-01	8.42e-01
GO:0055080	12	Up	5.46e-01	8.42e-01
GO:0006370	3	Down	5.49e-01	8.42e-01
GO:0018205	6	Up	5.51e-01	8.42e-01
GO:0009219	2	Up	5.51e-01	8.42e-01
GO:0006139	560	Down	5.56e-01	8.42e-01
GO:0009069	7	Up	5.58e-01	8.42e-01
GO:0051828	46	Up	5.60e-01	8.42e-01
GO:0044409	46	Up	5.60e-01	8.42e-01
GO:0042723	4	Up	5.61e-01	8.42e-01
GO:0006772	4	Up	5.61e-01	8.42e-01
GO:0042724	4	Up	5.61e-01	8.42e-01
GO:0009228	4	Up	5.61e-01	8.42e-01
GO:0000387	4	Down	5.62e-01	8.42e-01
GO:0006376	3	Down	5.62e-01	8.42e-01
GO:0006541	2	Down	5.63e-01	8.42e-01
GO:0015748	6	Down	5.64e-01	8.42e-01
GO:0006429	2	Down	5.64e-01	8.42e-01
GO:0044802	14	Down	5.64e-01	8.42e-01
GO:0033121	19	Up	5.65e-01	8.42e-01
GO:0030811	19	Up	5.65e-01	8.42e-01
GO:1900542	19	Up	5.65e-01	8.42e-01
GO:0009118	19	Up	5.65e-01	8.42e-01
GO:0006140	19	Up	5.65e-01	8.42e-01
GO:0031329	19	Up	5.65e-01	8.42e-01
GO:0045184	143	Down	5.65e-01	8.42e-01
GO:0016192	83	Up	5.67e-01	8.42e-01
GO:0031325	4	Down	5.68e-01	8.42e-01
GO:0009893	4	Down	5.68e-01	8.42e-01
GO:0010604	4	Down	5.68e-01	8.42e-01
GO:0009259	41	Up	5.68e-01	8.42e-01
GO:0051649	138	Down	5.68e-01	8.42e-01
GO:0006914	6	Down	5.68e-01	8.42e-01
GO:0019693	42	Up	5.69e-01	8.42e-01
GO:0006512	5	Down	5.69e-01	8.42e-01
GO:0006807	627	Down	5.70e-01	8.42e-01
GO:0006812	42	Up	5.76e-01	8.46e-01
GO:0016042	5	Up	5.76e-01	8.46e-01
GO:0017183	5	Up	5.77e-01	8.46e-01
GO:0017182	5	Up	5.77e-01	8.46e-01
GO:0006787	2	Down	5.78e-01	8.46e-01
GO:0033015	2	Down	5.78e-01	8.46e-01
GO:0051052	4	Up	5.82e-01	8.48e-01
GO:0040029	3	Down	5.82e-01	8.48e-01
GO:0015031	142	Down	5.82e-01	8.48e-01
GO:0032268	27	Down	5.85e-01	8.51e-01
GO:0032446	18	Down	5.86e-01	8.51e-01
GO:0000290	3	Down	5.90e-01	8.52e-01
GO:0000288	3	Down	5.90e-01	8.52e-01
GO:0015893	3	Up	5.91e-01	8.52e-01
GO:0006855	3	Up	5.91e-01	8.52e-01
GO:0090304	471	Down	5.93e-01	8.52e-01
GO:0055085	69	Up	5.93e-01	8.52e-01
GO:1902578	203	Up	5.94e-01	8.52e-01
GO:1902600	16	Up	5.95e-01	8.52e-01
GO:0009205	30	Up	5.96e-01	8.52e-01
GO:0009199	30	Up	5.96e-01	8.52e-01
GO:0008104	148	Down	5.96e-01	8.52e-01
GO:0006289	11	Up	6.00e-01	8.53e-01
GO:0009154	18	Down	6.04e-01	8.53e-01
GO:0006195	18	Down	6.04e-01	8.53e-01
GO:0009261	18	Down	6.04e-01	8.53e-01
GO:1901659	23	Up	6.06e-01	8.53e-01
GO:0015711	18	Down	6.07e-01	8.53e-01
GO:0009123	18	Up	6.08e-01	8.53e-01
GO:0009161	18	Up	6.08e-01	8.53e-01
GO:0016311	15	Down	6.10e-01	8.53e-01
GO:0043604	5	Up	6.11e-01	8.53e-01
GO:0008295	3	Up	6.11e-01	8.53e-01
GO:0042401	3	Up	6.11e-01	8.53e-01
GO:0009309	3	Up	6.11e-01	8.53e-01
GO:0006596	3	Up	6.11e-01	8.53e-01
GO:0006950	91	Down	6.11e-01	8.53e-01
GO:0007010	21	Up	6.12e-01	8.53e-01
GO:0042558	7	Down	6.17e-01	8.57e-01
GO:0070727	106	Down	6.18e-01	8.57e-01
GO:0034613	106	Down	6.18e-01	8.57e-01
GO:0034728	6	Down	6.19e-01	8.57e-01
GO:0006334	6	Down	6.19e-01	8.57e-01
GO:0051252	87	Down	6.24e-01	8.62e-01
GO:0006418	38	Down	6.24e-01	8.62e-01
GO:0009262	7	Up	6.27e-01	8.63e-01
GO:0046777	1	Up	6.28e-01	8.63e-01
GO:0009071	3	Up	6.31e-01	8.63e-01
GO:0006546	3	Up	6.31e-01	8.63e-01
GO:0046483	584	Down	6.32e-01	8.63e-01
GO:0030522	2	Down	6.34e-01	8.63e-01
GO:0046907	134	Down	6.34e-01	8.63e-01
GO:0006725	583	Down	6.34e-01	8.63e-01
GO:0051641	142	Down	6.35e-01	8.63e-01
GO:0032259	26	Down	6.36e-01	8.63e-01
GO:0000819	2	Down	6.39e-01	8.63e-01
GO:0000070	2	Down	6.39e-01	8.63e-01
GO:0051716	109	Up	6.40e-01	8.63e-01
GO:0044765	199	Up	6.40e-01	8.63e-01
GO:1901360	587	Down	6.42e-01	8.63e-01
GO:0034660	124	Down	6.42e-01	8.63e-01
GO:0009117	71	Down	6.42e-01	8.63e-01
GO:0009187	4	Down	6.43e-01	8.63e-01
GO:0009141	34	Up	6.44e-01	8.63e-01
GO:0015718	7	Down	6.44e-01	8.63e-01
GO:1901606	6	Up	6.45e-01	8.63e-01
GO:0009063	6	Up	6.45e-01	8.63e-01
GO:0015988	14	Up	6.46e-01	8.63e-01
GO:0015991	14	Up	6.46e-01	8.63e-01
GO:0009186	4	Up	6.48e-01	8.64e-01
GO:0007166	8	Up	6.49e-01	8.64e-01
GO:0006333	12	Down	6.50e-01	8.64e-01
GO:0051336	21	Up	6.52e-01	8.64e-01
GO:0009233	2	Up	6.52e-01	8.64e-01
GO:0009234	2	Up	6.52e-01	8.64e-01
GO:0009064	9	Down	6.55e-01	8.65e-01
GO:0006270	11	Up	6.55e-01	8.65e-01
GO:0006302	5	Up	6.59e-01	8.67e-01
GO:1901069	17	Down	6.62e-01	8.67e-01
GO:0006184	17	Down	6.62e-01	8.67e-01
GO:0009146	17	Down	6.62e-01	8.67e-01
GO:0009207	17	Down	6.62e-01	8.67e-01
GO:0009203	17	Down	6.62e-01	8.67e-01
GO:0071702	174	Down	6.64e-01	8.69e-01
GO:0018202	6	Up	6.66e-01	8.69e-01
GO:0048583	27	Down	6.67e-01	8.69e-01
GO:0031323	139	Down	6.67e-01	8.69e-01
GO:0010876	9	Down	6.71e-01	8.70e-01
GO:0006869	9	Down	6.71e-01	8.70e-01
GO:0043244	3	Down	6.71e-01	8.70e-01
GO:0097428	1	Down	6.71e-01	8.70e-01
GO:0006793	226	Up	6.73e-01	8.71e-01
GO:0071705	16	Down	6.75e-01	8.72e-01
GO:0048856	4	Up	6.76e-01	8.72e-01
GO:0000041	7	Up	6.83e-01	8.78e-01
GO:0002377	3	Up	6.84e-01	8.78e-01
GO:0002440	3	Up	6.84e-01	8.78e-01
GO:0009166	19	Down	6.85e-01	8.78e-01
GO:0006753	73	Down	6.85e-01	8.78e-01
GO:0030258	4	Down	6.89e-01	8.83e-01
GO:0000304	2	Up	6.93e-01	8.85e-01
GO:0022406	4	Down	6.95e-01	8.85e-01
GO:0048278	4	Down	6.95e-01	8.85e-01
GO:0006904	4	Down	6.95e-01	8.85e-01
GO:0046434	22	Down	6.99e-01	8.88e-01
GO:0016570	11	Down	7.09e-01	8.95e-01
GO:0016569	11	Down	7.09e-01	8.95e-01
GO:0006399	78	Up	7.10e-01	8.95e-01
GO:0009070	2	Up	7.10e-01	8.95e-01
GO:0051168	8	Down	7.11e-01	8.95e-01
GO:0051259	6	Up	7.12e-01	8.95e-01
GO:0019637	115	Down	7.13e-01	8.95e-01
GO:0044283	59	Up	7.14e-01	8.95e-01
GO:0009072	3	Up	7.14e-01	8.95e-01
GO:0009073	3	Up	7.14e-01	8.95e-01
GO:0048285	14	Up	7.15e-01	8.95e-01
GO:0000280	14	Up	7.15e-01	8.95e-01
GO:0009190	3	Down	7.25e-01	9.03e-01
GO:0006470	11	Up	7.25e-01	9.03e-01
GO:0044711	147	Up	7.25e-01	9.03e-01
GO:2001141	85	Down	7.26e-01	9.03e-01
GO:0006355	85	Down	7.26e-01	9.03e-01
GO:0009143	18	Down	7.29e-01	9.06e-01
GO:1901566	80	Up	7.33e-01	9.09e-01
GO:0006383	7	Down	7.36e-01	9.11e-01
GO:0050793	4	Up	7.37e-01	9.11e-01
GO:0043414	18	Down	7.38e-01	9.11e-01
GO:0045454	29	Down	7.38e-01	9.11e-01
GO:0009067	3	Down	7.44e-01	9.14e-01
GO:0008283	3	Up	7.45e-01	9.14e-01
GO:0006865	4	Up	7.45e-01	9.14e-01
GO:0006072	5	Down	7.47e-01	9.14e-01
GO:1901292	20	Down	7.48e-01	9.14e-01
GO:1902589	44	Down	7.50e-01	9.14e-01
GO:0046128	41	Up	7.51e-01	9.14e-01
GO:0042278	41	Up	7.51e-01	9.14e-01
GO:0000724	2	Down	7.52e-01	9.14e-01
GO:0000725	2	Down	7.52e-01	9.14e-01
GO:0006163	43	Up	7.53e-01	9.14e-01
GO:0009394	3	Down	7.55e-01	9.14e-01
GO:0019692	3	Down	7.55e-01	9.14e-01
GO:0009200	3	Down	7.55e-01	9.14e-01
GO:0015992	19	Up	7.55e-01	9.14e-01
GO:0006818	19	Up	7.55e-01	9.14e-01
GO:0055114	95	Up	7.59e-01	9.17e-01
GO:0006351	81	Down	7.62e-01	9.19e-01
GO:0042274	9	Down	7.62e-01	9.19e-01
GO:0009144	31	Up	7.65e-01	9.19e-01
GO:0060249	3	Down	7.66e-01	9.19e-01
GO:0000723	3	Down	7.66e-01	9.19e-01
GO:0032200	3	Down	7.66e-01	9.19e-01
GO:0044249	516	Up	7.73e-01	9.21e-01
GO:0006432	3	Up	7.75e-01	9.21e-01
GO:0009894	22	Down	7.75e-01	9.21e-01
GO:0046486	25	Up	7.75e-01	9.21e-01
GO:0048519	16	Down	7.76e-01	9.21e-01
GO:0006644	35	Up	7.76e-01	9.21e-01
GO:0006220	8	Up	7.77e-01	9.21e-01
GO:0017004	2	Up	7.79e-01	9.21e-01
GO:0042147	3	Down	7.80e-01	9.21e-01
GO:0016197	3	Down	7.80e-01	9.21e-01
GO:0006165	2	Up	7.81e-01	9.21e-01
GO:0046939	2	Up	7.81e-01	9.21e-01
GO:0032774	84	Down	7.82e-01	9.21e-01
GO:0031497	7	Down	7.84e-01	9.21e-01
GO:0006611	3	Up	7.86e-01	9.21e-01
GO:0044763	585	Up	7.86e-01	9.21e-01
GO:0046785	3	Up	7.86e-01	9.21e-01
GO:0031109	3	Up	7.86e-01	9.21e-01
GO:0007020	3	Up	7.86e-01	9.21e-01
GO:0006446	9	Up	7.87e-01	9.21e-01
GO:1901657	48	Down	7.89e-01	9.22e-01
GO:0019673	3	Down	7.95e-01	9.27e-01
GO:0042255	11	Down	7.96e-01	9.27e-01
GO:0090501	4	Down	8.01e-01	9.29e-01
GO:0055067	8	Down	8.01e-01	9.29e-01
GO:0006885	8	Down	8.01e-01	9.29e-01
GO:0070271	42	Down	8.02e-01	9.29e-01
GO:0006461	42	Down	8.02e-01	9.29e-01
GO:0016114	2	Down	8.04e-01	9.29e-01
GO:0006721	2	Down	8.04e-01	9.29e-01
GO:0001510	9	Up	8.06e-01	9.29e-01
GO:0052652	2	Down	8.06e-01	9.29e-01
GO:0046068	2	Down	8.06e-01	9.29e-01
GO:0006891	3	Up	8.14e-01	9.34e-01
GO:0007264	24	Down	8.15e-01	9.34e-01
GO:0006836	1	Down	8.17e-01	9.34e-01
GO:0015849	13	Down	8.17e-01	9.34e-01
GO:0046942	13	Down	8.17e-01	9.34e-01
GO:0006424	3	Up	8.18e-01	9.34e-01
GO:1901293	37	Up	8.19e-01	9.34e-01
GO:1902582	80	Down	8.19e-01	9.34e-01
GO:0006360	3	Down	8.21e-01	9.35e-01
GO:0016925	4	Down	8.21e-01	9.35e-01
GO:0071822	51	Down	8.22e-01	9.35e-01
GO:0046488	18	Up	8.24e-01	9.35e-01
GO:0034654	128	Down	8.25e-01	9.35e-01
GO:0006040	4	Up	8.27e-01	9.35e-01
GO:0009058	529	Up	8.27e-01	9.35e-01
GO:0035556	36	Down	8.27e-01	9.35e-01
GO:0018193	25	Up	8.30e-01	9.37e-01
GO:0019725	42	Up	8.33e-01	9.37e-01
GO:0009165	36	Up	8.37e-01	9.37e-01
GO:0045851	7	Up	8.37e-01	9.37e-01
GO:0030641	7	Up	8.37e-01	9.37e-01
GO:0051452	7	Up	8.37e-01	9.37e-01
GO:0007035	7	Up	8.37e-01	9.37e-01
GO:0051453	7	Up	8.37e-01	9.37e-01
GO:0030004	7	Up	8.37e-01	9.37e-01
GO:0043623	26	Down	8.40e-01	9.38e-01
GO:1901071	3	Down	8.41e-01	9.38e-01
GO:0006796	219	Up	8.41e-01	9.38e-01
GO:0007033	4	Down	8.43e-01	9.38e-01
GO:0006471	3	Up	8.47e-01	9.42e-01
GO:0006119	3	Down	8.52e-01	9.45e-01
GO:0042773	3	Down	8.52e-01	9.45e-01
GO:0051179	346	Up	8.53e-01	9.46e-01
GO:0009116	47	Down	8.55e-01	9.46e-01
GO:0072528	14	Down	8.60e-01	9.50e-01
GO:0007154	59	Down	8.61e-01	9.50e-01
GO:0009225	4	Up	8.66e-01	9.55e-01
GO:0022900	7	Up	8.69e-01	9.57e-01
GO:0006310	18	Down	8.70e-01	9.57e-01
GO:1901068	19	Down	8.72e-01	9.57e-01
GO:0052646	6	Up	8.75e-01	9.57e-01
GO:1901576	518	Up	8.75e-01	9.57e-01
GO:0008299	7	Down	8.76e-01	9.57e-01
GO:0006720	7	Down	8.76e-01	9.57e-01
GO:0051171	110	Down	8.77e-01	9.57e-01
GO:0019219	110	Down	8.77e-01	9.57e-01
GO:0006928	33	Down	8.79e-01	9.58e-01
GO:0034637	3	Down	8.84e-01	9.61e-01
GO:0023052	54	Up	8.85e-01	9.61e-01
GO:0044700	54	Up	8.85e-01	9.61e-01
GO:0007165	54	Up	8.85e-01	9.61e-01
GO:0006650	24	Up	8.89e-01	9.62e-01
GO:0022603	2	Up	8.89e-01	9.62e-01
GO:0042592	47	Up	8.89e-01	9.62e-01
GO:0034220	19	Up	8.93e-01	9.65e-01
GO:0070972	8	Down	8.94e-01	9.65e-01
GO:0043085	4	Down	8.97e-01	9.66e-01
GO:0044093	4	Down	8.97e-01	9.66e-01
GO:0006810	332	Up	8.99e-01	9.67e-01
GO:0000393	5	Down	9.08e-01	9.69e-01
GO:0008216	4	Down	9.08e-01	9.69e-01
GO:0006595	4	Down	9.08e-01	9.69e-01
GO:0051234	333	Up	9.11e-01	9.69e-01
GO:0007017	31	Up	9.12e-01	9.69e-01
GO:0010639	3	Down	9.14e-01	9.69e-01
GO:0051129	3	Down	9.14e-01	9.69e-01
GO:0030837	3	Down	9.14e-01	9.69e-01
GO:0051494	3	Down	9.14e-01	9.69e-01
GO:0032272	3	Down	9.14e-01	9.69e-01
GO:0031333	3	Down	9.14e-01	9.69e-01
GO:0044271	158	Up	9.15e-01	9.69e-01
GO:0015908	3	Up	9.17e-01	9.69e-01
GO:0046578	17	Down	9.17e-01	9.69e-01
GO:0051056	17	Down	9.17e-01	9.69e-01
GO:1902531	17	Down	9.17e-01	9.69e-01
GO:0046394	39	Up	9.28e-01	9.76e-01
GO:0016053	39	Up	9.28e-01	9.76e-01
GO:0051187	3	Down	9.32e-01	9.76e-01
GO:0006405	4	Down	9.32e-01	9.76e-01
GO:0006613	5	Down	9.34e-01	9.76e-01
GO:0006614	5	Down	9.34e-01	9.76e-01
GO:0006606	10	Down	9.34e-01	9.76e-01
GO:0051170	10	Down	9.34e-01	9.76e-01
GO:0034504	10	Down	9.34e-01	9.76e-01
GO:1902593	10	Down	9.34e-01	9.76e-01
GO:0044744	10	Down	9.34e-01	9.76e-01
GO:0006811	79	Down	9.40e-01	9.80e-01
GO:0042819	3	Up	9.42e-01	9.80e-01
GO:0042816	3	Up	9.42e-01	9.80e-01
GO:0008614	3	Up	9.42e-01	9.80e-01
GO:0072521	48	Up	9.44e-01	9.80e-01
GO:0044710	420	Down	9.46e-01	9.80e-01
GO:0072525	4	Down	9.48e-01	9.80e-01
GO:0032313	13	Down	9.49e-01	9.80e-01
GO:0032483	13	Down	9.49e-01	9.80e-01
GO:0034470	83	Down	9.49e-01	9.80e-01
GO:0006749	4	Up	9.56e-01	9.84e-01
GO:0022904	6	Up	9.58e-01	9.84e-01
GO:0032270	3	Up	9.58e-01	9.84e-01
GO:0051247	3	Up	9.58e-01	9.84e-01
GO:0009059	385	Up	9.59e-01	9.84e-01
GO:0019438	148	Up	9.59e-01	9.84e-01
GO:0015931	11	Down	9.60e-01	9.84e-01
GO:0009119	46	Down	9.61e-01	9.85e-01
GO:0034645	383	Up	9.62e-01	9.85e-01
GO:0010646	21	Up	9.66e-01	9.85e-01
GO:0023051	21	Up	9.66e-01	9.85e-01
GO:0009966	21	Up	9.66e-01	9.85e-01
GO:0016458	3	Down	9.69e-01	9.85e-01
GO:0072511	6	Down	9.70e-01	9.85e-01
GO:0070838	6	Down	9.70e-01	9.85e-01
GO:0030048	4	Up	9.70e-01	9.85e-01
GO:0046039	18	Down	9.74e-01	9.88e-01
GO:0018130	152	Down	9.75e-01	9.88e-01
GO:0006308	4	Up	9.75e-01	9.88e-01
GO:0072527	15	Up	9.78e-01	9.89e-01
GO:0006888	20	Up	9.91e-01	9.99e-01
GO:0006607	3	Down	9.92e-01	9.99e-01
GO:0046903	5	Up	9.93e-01	9.99e-01
GO:0006887	5	Up	9.93e-01	9.99e-01
GO:0032940	5	Up	9.93e-01	9.99e-01
GO:0007034	5	Down	9.93e-01	9.99e-01
GO:0043952	5	Down	9.94e-01	9.99e-01
GO:0006221	7	Up	9.96e-01	9.99e-01
GO:0009432	2	Down	9.98e-01	9.99e-01
GO:0000096	3	Up	9.98e-01	9.99e-01
GO:1901362	155	Up	9.99e-01	9.99e-01

Now KEGG pathway enrichment again making use of mroast and camera.

indices <- ids2indices(kegg.gene.sets, rownames(v2))
keg_mr <- mroast(v2, index = indices, design = modRUV, contrast = 2, nrot = 10000, set.statistic = "floormean")
keg_cam <- camera(v2, index = indices, design = modRUV, contrast = 2)

keg_mr$PValue <- format(keg_mr$PValue, scientific = TRUE, digits = 3)
keg_mr$FDR <- format(keg_mr$FDR, scientific = TRUE, digits = 3)
keg_mr$PValue.Mixed <- format(keg_mr$PValue.Mixed, scientific = TRUE, digits = 3)
keg_mr$FDR.Mixed <- format(keg_mr$FDR.Mixed, scientific = TRUE, digits = 3)
kable(keg_mr, digits = 3)

	NGenes	PropDown	PropUp	Direction	PValue	FDR	PValue.Mixed	FDR.Mixed
ec00250__PK__KEGG	12	0.250	0.000	Down	3.30e-03	9.75e-02	1.30e-02	2.82e-02
ec00740__PK__KEGG	8	0.375	0.500	Up	3.60e-03	9.75e-02	4.00e-04	1.53e-02
ec00710__PK__KEGG	10	0.600	0.000	Down	4.00e-03	9.75e-02	6.10e-03	2.04e-02
ec00280__PK__KEGG	8	0.125	0.500	Up	4.50e-03	9.75e-02	4.80e-03	1.85e-02
ec00600__PK__KEGG	11	0.091	0.545	Up	5.30e-03	9.75e-02	4.00e-03	1.72e-02
ec00650__PK__KEGG	18	0.056	0.444	Up	5.60e-03	9.75e-02	9.40e-03	2.37e-02
ec00010__PK__KEGG	25	0.440	0.080	Down	7.00e-03	9.75e-02	4.20e-03	1.74e-02
ec00562__PK__KEGG	18	0.278	0.111	Down	8.70e-03	9.75e-02	6.40e-03	2.04e-02
ec00020__PK__KEGG	18	0.111	0.389	Up	8.90e-03	9.75e-02	2.10e-03	1.53e-02
ec00380__PK__KEGG	61	0.180	0.246	Up	9.00e-03	9.75e-02	2.30e-03	1.53e-02
ec00565__PK__KEGG	24	0.208	0.292	Up	1.22e-02	9.96e-02	8.00e-04	1.53e-02
ec00561__PK__KEGG	15	0.133	0.200	Up	1.32e-02	9.96e-02	3.80e-03	1.72e-02
ec00591__PK__KEGG	7	0.286	0.143	Down	1.39e-02	9.96e-02	3.10e-03	1.72e-02
ec00230__PK__KEGG	78	0.244	0.128	Down	1.39e-02	9.96e-02	9.00e-04	1.53e-02
ec00720__PK__KEGG	17	0.118	0.412	Up	1.79e-02	9.96e-02	8.70e-03	2.35e-02
ec00900__PK__KEGG	26	0.077	0.269	Up	1.87e-02	9.96e-02	7.00e-03	2.16e-02
ec00030__PK__KEGG	14	0.429	0.000	Down	1.95e-02	9.96e-02	2.60e-02	4.32e-02
ec00983__PK__KEGG	15	0.400	0.067	Down	2.00e-02	9.96e-02	1.24e-02	2.75e-02
ec00590__PK__KEGG	7	0.286	0.000	Down	2.06e-02	9.96e-02	1.15e-02	2.65e-02
ec00361__PK__KEGG	6	0.167	0.500	Up	2.25e-02	9.96e-02	1.08e-02	2.57e-02
ec00362__PK__KEGG	19	0.158	0.368	Up	2.44e-02	9.96e-02	1.58e-02	3.09e-02
ec00440__PK__KEGG	4	0.500	0.000	Down	2.64e-02	9.96e-02	2.62e-02	4.32e-02
ec00624__PK__KEGG	36	0.222	0.222	Up	2.76e-02	9.96e-02	1.40e-03	1.53e-02
ec00240__PK__KEGG	72	0.194	0.167	Up	2.90e-02	9.96e-02	6.00e-04	1.53e-02
ec00627__PK__KEGG	61	0.213	0.246	Up	2.94e-02	9.96e-02	1.70e-03	1.53e-02
ec00351__PK__KEGG	1	0.000	1.000	Up	2.97e-02	9.96e-02	2.97e-02	4.71e-02
ec00730__PK__KEGG	14	0.071	0.214	Up	3.03e-02	9.96e-02	4.21e-02	6.28e-02
ec00660__PK__KEGG	3	0.000	0.667	Up	3.14e-02	9.96e-02	3.29e-02	5.11e-02
ec00625__PK__KEGG	4	0.250	0.250	Down	3.25e-02	9.96e-02	2.35e-02	4.12e-02
ec00623__PK__KEGG	17	0.118	0.353	Up	3.36e-02	9.96e-02	1.17e-02	2.65e-02
ec00062__PK__KEGG	6	0.167	0.667	Up	3.40e-02	9.96e-02	1.60e-02	3.09e-02
ec00860__PK__KEGG	50	0.160	0.200	Up	3.40e-02	9.96e-02	1.09e-02	2.57e-02
ec00970__PK__KEGG	41	0.341	0.171	Down	3.52e-02	9.96e-02	7.50e-03	2.19e-02
ec00360__PK__KEGG	49	0.204	0.245	Up	3.61e-02	9.96e-02	1.20e-03	1.53e-02
ec00942__PK__KEGG	46	0.174	0.261	Up	3.76e-02	9.96e-02	4.40e-03	1.76e-02
ec00941__PK__KEGG	36	0.222	0.222	Up	3.79e-02	9.96e-02	1.30e-03	1.53e-02
ec00945__PK__KEGG	36	0.222	0.222	Up	3.84e-02	9.96e-02	1.60e-03	1.53e-02
ec00270__PK__KEGG	49	0.224	0.204	Up	3.86e-02	9.96e-02	1.90e-03	1.53e-02
ec01057__PK__KEGG	42	0.190	0.238	Up	3.93e-02	9.96e-02	3.80e-03	1.72e-02
ec00053__PK__KEGG	7	0.143	0.286	Up	3.95e-02	9.96e-02	5.30e-03	1.85e-02
ec01051__PK__KEGG	36	0.222	0.222	Up	3.99e-02	9.96e-02	2.20e-03	1.53e-02
ec00260__PK__KEGG	16	0.062	0.438	Up	4.05e-02	9.96e-02	2.10e-02	3.94e-02
ec00253__PK__KEGG	51	0.176	0.235	Up	4.05e-02	9.96e-02	3.90e-03	1.72e-02
ec00130__PK__KEGG	40	0.225	0.200	Up	4.13e-02	9.96e-02	2.20e-03	1.53e-02
ec00340__PK__KEGG	46	0.196	0.239	Up	4.14e-02	9.96e-02	3.20e-03	1.72e-02
ec00920__PK__KEGG	4	0.000	0.500	Up	4.21e-02	9.96e-02	6.63e-02	8.69e-02
ec00350__PK__KEGG	50	0.200	0.220	Up	4.39e-02	1.01e-01	2.60e-03	1.54e-02
ec00450__PK__KEGG	41	0.195	0.220	Up	4.47e-02	1.01e-01	2.00e-03	1.53e-02
ec00940__PK__KEGG	48	0.188	0.229	Up	4.72e-02	1.03e-01	2.10e-03	1.53e-02
ec00981__PK__KEGG	38	0.184	0.237	Up	4.77e-02	1.03e-01	5.30e-03	1.85e-02
ec00903__PK__KEGG	16	0.188	0.312	Up	4.83e-02	1.03e-01	1.62e-02	3.09e-02
ec00965__PK__KEGG	12	0.083	0.417	Up	5.48e-02	1.14e-01	4.89e-02	7.19e-02
ec00480__PK__KEGG	25	0.200	0.280	Up	5.59e-02	1.14e-01	2.50e-03	1.54e-02
ec00910__PK__KEGG	6	0.167	0.000	Down	5.74e-02	1.14e-01	7.78e-02	9.41e-02
ec00564__PK__KEGG	53	0.151	0.264	Up	5.82e-02	1.14e-01	7.70e-03	2.19e-02
ec00310__PK__KEGG	40	0.225	0.275	Up	6.08e-02	1.14e-01	5.30e-03	1.85e-02
ec00603__PK__KEGG	1	0.000	1.000	Up	6.13e-02	1.14e-01	6.13e-02	8.69e-02
ec00592__PK__KEGG	9	0.222	0.222	Down	6.29e-02	1.14e-01	6.40e-03	2.04e-02
ec00522__PK__KEGG	1	0.000	1.000	Up	6.37e-02	1.14e-01	6.37e-02	8.69e-02
ec00513__PK__KEGG	1	0.000	1.000	Up	6.40e-02	1.14e-01	6.40e-02	8.69e-02
ec00944__PK__KEGG	1	0.000	1.000	Up	6.43e-02	1.14e-01	6.43e-02	8.69e-02
ec00604__PK__KEGG	1	0.000	1.000	Up	6.50e-02	1.14e-01	6.50e-02	8.69e-02
ec00512__PK__KEGG	1	0.000	1.000	Up	6.78e-02	1.15e-01	6.78e-02	8.69e-02
ec00906__PK__KEGG	13	0.154	0.385	Up	6.78e-02	1.15e-01	1.62e-02	3.09e-02
ec00601__PK__KEGG	1	0.000	1.000	Up	6.88e-02	1.15e-01	6.88e-02	8.71e-02
ec00626__PK__KEGG	13	0.154	0.308	Up	7.59e-02	1.25e-01	2.99e-02	4.71e-02
ec00982__PK__KEGG	3	0.333	0.333	Down	7.68e-02	1.25e-01	3.92e-02	5.93e-02
ec00630__PK__KEGG	9	0.111	0.444	Up	7.96e-02	1.27e-01	1.35e-02	2.87e-02
ec00680__PK__KEGG	24	0.208	0.292	Up	8.24e-02	1.27e-01	9.70e-03	2.39e-02
ec00950__PK__KEGG	48	0.167	0.229	Up	8.29e-02	1.27e-01	8.90e-03	2.35e-02
ec00330__PK__KEGG	27	0.074	0.296	Up	8.44e-02	1.27e-01	1.40e-02	2.92e-02
ec00966__PK__KEGG	3	0.333	0.333	Down	8.49e-02	1.27e-01	2.68e-02	4.35e-02
ec00140__PK__KEGG	3	0.333	0.333	Down	8.60e-02	1.27e-01	2.47e-02	4.20e-02
ec00540__PK__KEGG	11	0.091	0.364	Up	8.63e-02	1.27e-01	7.69e-02	9.41e-02
ec00300__PK__KEGG	19	0.158	0.211	Up	8.81e-02	1.28e-01	2.14e-02	3.94e-02
ec00622__PK__KEGG	4	0.250	0.500	Up	9.24e-02	1.31e-01	9.10e-03	2.35e-02
ec00231__PK__KEGG	11	0.091	0.364	Up	9.29e-02	1.31e-01	5.69e-02	8.26e-02
ec00930__PK__KEGG	7	0.143	0.429	Up	9.76e-02	1.36e-01	1.05e-01	1.25e-01
ec00790__PK__KEGG	9	0.222	0.222	Down	1.00e-01	1.37e-01	4.00e-03	1.72e-02
ec00770__PK__KEGG	8	0.000	0.250	Up	1.02e-01	1.37e-01	1.24e-01	1.43e-01
ec00904__PK__KEGG	12	0.167	0.333	Up	1.04e-01	1.37e-01	2.44e-02	4.20e-02
ec00071__PK__KEGG	18	0.278	0.333	Up	1.05e-01	1.37e-01	2.22e-02	3.96e-02
ec00281__PK__KEGG	4	0.250	0.500	Up	1.05e-01	1.37e-01	6.70e-02	8.69e-02
ec00670__PK__KEGG	7	0.000	0.429	Up	1.05e-01	1.37e-01	1.38e-01	1.56e-01
ec00642__PK__KEGG	13	0.154	0.308	Up	1.07e-01	1.37e-01	6.74e-02	8.69e-02
ec00785__PK__KEGG	2	0.000	0.500	Up	1.10e-01	1.40e-01	1.66e-01	1.85e-01
ec00640__PK__KEGG	17	0.118	0.294	Up	1.45e-01	1.81e-01	7.60e-03	2.19e-02
ec00364__PK__KEGG	6	0.167	0.333	Up	1.46e-01	1.81e-01	1.11e-01	1.30e-01
ec00830__PK__KEGG	5	0.200	0.200	Down	1.49e-01	1.83e-01	2.18e-02	3.95e-02
ec00510__PK__KEGG	3	0.000	0.333	Up	1.56e-01	1.87e-01	2.28e-01	2.46e-01
ec00620__PK__KEGG	23	0.174	0.174	Up	1.58e-01	1.87e-01	8.90e-03	2.35e-02
ec00563__PK__KEGG	7	0.000	0.429	Up	1.58e-01	1.87e-01	1.87e-01	2.05e-01
ec00051__PK__KEGG	20	0.150	0.150	Down	1.71e-01	2.01e-01	1.61e-02	3.09e-02
ec00040__PK__KEGG	6	0.000	0.333	Up	1.87e-01	2.17e-01	3.29e-01	3.41e-01
ec00960__PK__KEGG	18	0.167	0.222	Up	2.29e-01	2.62e-01	6.31e-02	8.69e-02
ec00908__PK__KEGG	2	0.000	0.500	Up	2.33e-01	2.64e-01	7.42e-02	9.20e-02
ec00363__PK__KEGG	6	0.167	0.167	Down	2.37e-01	2.66e-01	3.40e-02	5.21e-02
ec00061__PK__KEGG	9	0.222	0.222	Up	2.62e-01	2.91e-01	7.86e-02	9.41e-02
ec01056__PK__KEGG	3	0.000	0.333	Up	2.84e-01	3.12e-01	4.18e-01	4.26e-01
ec00500__PK__KEGG	5	0.200	0.200	Down	2.97e-01	3.23e-01	1.27e-01	1.45e-01
ec00760__PK__KEGG	12	0.083	0.250	Up	3.00e-01	3.24e-01	1.53e-01	1.72e-01
ec00633__PK__KEGG	4	0.000	0.500	Up	3.08e-01	3.29e-01	2.83e-01	2.99e-01
ec00400__PK__KEGG	8	0.000	0.250	Up	3.15e-01	3.33e-01	4.61e-01	4.65e-01
ec00410__PK__KEGG	4	0.000	0.250	Down	3.50e-01	3.67e-01	7.43e-02	9.20e-02
ec00750__PK__KEGG	2	0.000	0.000	Up	4.55e-01	4.72e-01	4.06e-01	4.18e-01
ec00780__PK__KEGG	13	0.154	0.077	Up	5.11e-01	5.26e-01	1.94e-01	2.12e-01
ec00052__PK__KEGG	8	0.125	0.125	Down	5.80e-01	5.91e-01	2.81e-01	2.99e-01
ec00520__PK__KEGG	21	0.095	0.143	Down	5.86e-01	5.91e-01	3.03e-01	3.18e-01
ec00521__PK__KEGG	5	0.000	0.000	Down	6.06e-01	6.06e-01	8.40e-01	8.40e-01

Also test using limma’s camera

keg_cam$PValue <- format(keg_cam$PValue, scientific = TRUE, digits = 3)
keg_cam$FDR <- format(keg_cam$FDR, scientific = TRUE, digits = 3)
kable(keg_cam, digits = 3)

	NGenes	Direction	PValue	FDR
ec00710__PK__KEGG	10	Down	2.10e-03	2.29e-01
ec00010__PK__KEGG	25	Down	4.86e-03	2.65e-01
ec00600__PK__KEGG	11	Up	2.59e-02	6.94e-01
ec00250__PK__KEGG	12	Down	2.85e-02	6.94e-01
ec00900__PK__KEGG	26	Up	4.18e-02	6.94e-01
ec00650__PK__KEGG	18	Up	4.36e-02	6.94e-01
ec00030__PK__KEGG	14	Down	4.87e-02	6.94e-01
ec00440__PK__KEGG	4	Down	5.64e-02	6.94e-01
ec00983__PK__KEGG	15	Down	5.73e-02	6.94e-01
ec00020__PK__KEGG	18	Up	7.10e-02	7.25e-01
ec00920__PK__KEGG	4	Up	7.43e-02	7.25e-01
ec00562__PK__KEGG	18	Down	8.85e-02	7.25e-01
ec00720__PK__KEGG	17	Up	1.20e-01	7.25e-01
ec00965__PK__KEGG	12	Up	1.45e-01	7.25e-01
ec00260__PK__KEGG	16	Up	1.50e-01	7.25e-01
ec00565__PK__KEGG	24	Up	1.68e-01	7.25e-01
ec00280__PK__KEGG	8	Up	1.77e-01	7.25e-01
ec00730__PK__KEGG	14	Up	1.85e-01	7.25e-01
ec00660__PK__KEGG	3	Up	1.87e-01	7.25e-01
ec00670__PK__KEGG	7	Up	1.92e-01	7.25e-01
ec00351__PK__KEGG	1	Up	1.93e-01	7.25e-01
ec00860__PK__KEGG	50	Up	2.10e-01	7.25e-01
ec00601__PK__KEGG	1	Up	2.20e-01	7.25e-01
ec00944__PK__KEGG	1	Up	2.20e-01	7.25e-01
ec00522__PK__KEGG	1	Up	2.20e-01	7.25e-01
ec00513__PK__KEGG	1	Up	2.20e-01	7.25e-01
ec00603__PK__KEGG	1	Up	2.20e-01	7.25e-01
ec00604__PK__KEGG	1	Up	2.20e-01	7.25e-01
ec00512__PK__KEGG	1	Up	2.20e-01	7.25e-01
ec00361__PK__KEGG	6	Up	2.26e-01	7.25e-01
ec00942__PK__KEGG	46	Up	2.31e-01	7.25e-01
ec00770__PK__KEGG	8	Up	2.32e-01	7.25e-01
ec00590__PK__KEGG	7	Down	2.38e-01	7.25e-01
ec00540__PK__KEGG	11	Up	2.40e-01	7.25e-01
ec00062__PK__KEGG	6	Up	2.42e-01	7.25e-01
ec00910__PK__KEGG	6	Down	2.46e-01	7.25e-01
ec00623__PK__KEGG	17	Up	2.49e-01	7.25e-01
ec00563__PK__KEGG	7	Up	2.53e-01	7.25e-01
ec00561__PK__KEGG	15	Up	2.69e-01	7.46e-01
ec00362__PK__KEGG	19	Up	2.86e-01	7.46e-01
ec00510__PK__KEGG	3	Up	3.12e-01	7.46e-01
ec00380__PK__KEGG	61	Up	3.19e-01	7.46e-01
ec00564__PK__KEGG	53	Up	3.29e-01	7.46e-01
ec00740__PK__KEGG	8	Up	3.30e-01	7.46e-01
ec00633__PK__KEGG	4	Up	3.46e-01	7.46e-01
ec00760__PK__KEGG	12	Up	3.48e-01	7.46e-01
ec00930__PK__KEGG	7	Up	3.57e-01	7.46e-01
ec00040__PK__KEGG	6	Up	3.58e-01	7.46e-01
ec00970__PK__KEGG	41	Down	3.68e-01	7.46e-01
ec00906__PK__KEGG	13	Up	3.69e-01	7.46e-01
ec01057__PK__KEGG	42	Up	3.76e-01	7.46e-01
ec00981__PK__KEGG	38	Up	3.78e-01	7.46e-01
ec00627__PK__KEGG	61	Up	3.83e-01	7.46e-01
ec00253__PK__KEGG	51	Up	3.84e-01	7.46e-01
ec00642__PK__KEGG	13	Up	4.05e-01	7.46e-01
ec01056__PK__KEGG	3	Up	4.10e-01	7.46e-01
ec00340__PK__KEGG	46	Up	4.15e-01	7.46e-01
ec00940__PK__KEGG	48	Up	4.19e-01	7.46e-01
ec00625__PK__KEGG	4	Down	4.30e-01	7.46e-01
ec00231__PK__KEGG	11	Up	4.41e-01	7.46e-01
ec00230__PK__KEGG	78	Down	4.49e-01	7.46e-01
ec00785__PK__KEGG	2	Up	4.50e-01	7.46e-01
ec00626__PK__KEGG	13	Up	4.74e-01	7.46e-01
ec00903__PK__KEGG	16	Up	4.77e-01	7.46e-01
ec00591__PK__KEGG	7	Down	4.77e-01	7.46e-01
ec00950__PK__KEGG	48	Up	4.79e-01	7.46e-01
ec00630__PK__KEGG	9	Up	4.82e-01	7.46e-01
ec00400__PK__KEGG	8	Up	4.91e-01	7.46e-01
ec00350__PK__KEGG	50	Up	4.94e-01	7.46e-01
ec00360__PK__KEGG	49	Up	5.09e-01	7.46e-01
ec00364__PK__KEGG	6	Up	5.17e-01	7.46e-01
ec01051__PK__KEGG	36	Up	5.23e-01	7.46e-01
ec00281__PK__KEGG	4	Up	5.31e-01	7.46e-01
ec00750__PK__KEGG	2	Up	5.36e-01	7.46e-01
ec00061__PK__KEGG	9	Up	5.36e-01	7.46e-01
ec00450__PK__KEGG	41	Up	5.44e-01	7.46e-01
ec00053__PK__KEGG	7	Up	5.46e-01	7.46e-01
ec00904__PK__KEGG	12	Up	5.46e-01	7.46e-01
ec00982__PK__KEGG	3	Down	5.58e-01	7.46e-01
ec00330__PK__KEGG	27	Up	5.61e-01	7.46e-01
ec00966__PK__KEGG	3	Down	5.79e-01	7.46e-01
ec00140__PK__KEGG	3	Down	5.79e-01	7.46e-01
ec00624__PK__KEGG	36	Up	5.81e-01	7.46e-01
ec00521__PK__KEGG	5	Down	5.88e-01	7.46e-01
ec00941__PK__KEGG	36	Up	5.89e-01	7.46e-01
ec00945__PK__KEGG	36	Up	5.89e-01	7.46e-01
ec00071__PK__KEGG	18	Up	6.42e-01	8.04e-01
ec00480__PK__KEGG	25	Up	6.91e-01	8.50e-01
ec00830__PK__KEGG	5	Down	7.12e-01	8.50e-01
ec00908__PK__KEGG	2	Up	7.15e-01	8.50e-01
ec00960__PK__KEGG	18	Up	7.17e-01	8.50e-01
ec00310__PK__KEGG	40	Up	7.26e-01	8.50e-01
ec00300__PK__KEGG	19	Up	7.31e-01	8.50e-01
ec00130__PK__KEGG	40	Up	7.33e-01	8.50e-01
ec00500__PK__KEGG	5	Down	7.44e-01	8.53e-01
ec00240__PK__KEGG	72	Up	7.73e-01	8.78e-01
ec00780__PK__KEGG	13	Up	7.95e-01	8.86e-01
ec00640__PK__KEGG	17	Up	7.97e-01	8.86e-01
ec00270__PK__KEGG	49	Up	8.28e-01	9.12e-01
ec00520__PK__KEGG	21	Down	8.39e-01	9.14e-01
ec00051__PK__KEGG	20	Down	8.51e-01	9.14e-01
ec00680__PK__KEGG	24	Up	8.55e-01	9.14e-01
ec00622__PK__KEGG	4	Up	8.71e-01	9.22e-01
ec00620__PK__KEGG	23	Up	8.90e-01	9.30e-01
ec00363__PK__KEGG	6	Down	9.00e-01	9.30e-01
ec00790__PK__KEGG	9	Down	9.05e-01	9.30e-01
ec00410__PK__KEGG	4	Down	9.15e-01	9.32e-01
ec00052__PK__KEGG	8	Down	9.27e-01	9.35e-01
ec00592__PK__KEGG	9	Down	9.51e-01	9.51e-01

Gene sets from Daily et al and Shock et al

We now test using roast and camera for deregulation of gene sets obtained from the papers:

Daily, J. P., D. Scanfeld, N. Pochet, K. Le Roch, D. Plouffe, M. Kamal, O. Sarr, et al. 2007. “Distinct Physiological States of Plasmodium Falciparum in Malaria-Infected Patients.” Nature 450 (7172): 1091–95.

Shock, Jennifer L., Kael F. Fischer, and Joseph L. DeRisi. 2007. “Whole-Genome Analysis of mRNA Decay in Plasmodium Falciparum Reveals a Global Lengthening of mRNA Half-Life during the Intra-Erythrocytic Development Cycle.” Genome Biology 8 (7): R134.

setwd(wd)

# Load gene lists from Daily et al and Shock et al
daily_figure2 <- fread("./data/daily_expression_figure2.csv", data.table = FALSE, header = TRUE)

JLshock <- c("PF3D7_0320800", "PF3D7_0410400", "PF3D7_0507600", "PF3D7_0520300", "PF3D7_0720000", "PF3D7_0811300", "PF3D7_0819900", "PF3D7_0909400", "PF3D7_0909900", 
    "PF3D7_1006100", "PF3D7_1032100", "PF3D7_1103800", "PF3D7_1106300", "PF3D7_1107000", "PF3D7_1124400", "PF3D7_1128600", "PF3D7_1209200", "PF3D7_1224300", 
    "PF3D7_1235300", "PF3D7_1307000", "PF3D7_1308900", "PF3D7_1325000", "PF3D7_1340100", "PF3D7_1364500", "PF3D7_1427800", "PF3D7_1443300", "PF3D7_1443500", 
    "PF3D7_1449700", "PF3D7_0519500")

# Load entrex geneID mappings
entrez_geneID_mappings <- fread("./data/geneID_mappings.txt", data.table = FALSE, stringsAsFactors = FALSE)

upcluster2 <- daily_figure2$Gene[daily_figure2$`Up regulated in Cluster 2?` == "Y"]
upcluster1 <- daily_figure2$Gene[daily_figure2$`Up regulated in Cluster 2?` == "N"]
glycolisis <- daily_figure2$Gene[daily_figure2$type == "Glycolisis"]
tricarboxylic <- daily_figure2$Gene[daily_figure2$type == "Tricarboxylic acid cycle"]
fatty_acid <- daily_figure2$Gene[daily_figure2$type == "Fatty acid metabolism"]

upcluster2 <- as.vector(geneID_mappings$current[geneID_mappings$old %in% upcluster2])
upcluster1 <- as.vector(geneID_mappings$current[geneID_mappings$old %in% upcluster1])
glycolisis <- as.vector(geneID_mappings$current[geneID_mappings$old %in% glycolisis])
tricarboxylic <- as.vector(geneID_mappings$current[geneID_mappings$old %in% tricarboxylic])
fatty_acid <- as.vector(geneID_mappings$current[geneID_mappings$old %in% fatty_acid])

indices <- ids2indices(list(up_in_starvation = upcluster1, up_int_vitro = upcluster2, glycolisis = glycolisis, tricarboxylic = tricarboxylic, fatty_acid = fatty_acid, 
    mRNA_degradation = JLshock), rownames(v2$E))
mroast(v2, index = indices, design = modRUV, contrast = 2, nrot = 10000, set.statistic = "floormean")

##                  NGenes  PropDown     PropUp Direction     PValue        FDR PValue.Mixed  FDR.Mixed
## up_int_vitro         12 0.8333333 0.00000000      Down 0.01129887 0.02812219   0.01249875 0.01493851
## glycolisis           19 0.5789474 0.05263158      Down 0.01309869 0.02812219   0.01009899 0.01493851
## mRNA_degradation     29 0.2758621 0.06896552      Down 0.01459854 0.02812219   0.00769923 0.01493851
## tricarboxylic        11 0.1818182 0.36363636        Up 0.01879812 0.02812219   0.00129987 0.00749925
## up_in_starvation     33 0.1818182 0.21212121        Up 0.06249375 0.07493251   0.00929907 0.01493851
## fatty_acid           17 0.1764706 0.11764706        Up 0.12558744 0.12558744   0.07129287 0.07129287

camera(v2, index = indices, design = modRUV, contrast = 2)

##                  NGenes Direction       PValue          FDR
## up_int_vitro         12      Down 1.470968e-05 8.825807e-05
## glycolisis           19      Down 1.322405e-03 3.967216e-03
## mRNA_degradation     29      Down 8.826335e-02 1.765267e-01
## up_in_starvation     33        Up 2.390539e-01 3.166989e-01
## tricarboxylic        11        Up 2.639157e-01 3.166989e-01
## fatty_acid           17        Up 3.466823e-01 3.466823e-01

System Information

setwd(wd)
sessionInfo()

## R version 3.4.3 (2017-11-30)
## Platform: x86_64-apple-darwin15.6.0 (64-bit)
## Running under: OS X El Capitan 10.11.6
## 
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/3.4/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/3.4/Resources/lib/libRlapack.dylib
## 
## locale:
## [1] en_AU.UTF-8/en_AU.UTF-8/en_AU.UTF-8/C/en_AU.UTF-8/en_AU.UTF-8
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pheatmap_1.0.8             knitr_1.17                 stringr_1.2.0              dplyr_0.7.4                data.table_1.10.4-3       
##  [6] VennDiagram_1.6.18         futile.logger_1.4.3        RColorBrewer_1.1-2         EDASeq_2.10.0              ShortRead_1.34.2          
## [11] GenomicAlignments_1.12.2   SummarizedExperiment_1.6.5 DelayedArray_0.2.7         matrixStats_0.52.2         Rsamtools_1.28.0          
## [16] GenomicRanges_1.28.6       GenomeInfoDb_1.12.3        Biostrings_2.44.2          XVector_0.16.0             IRanges_2.10.5            
## [21] S4Vectors_0.14.7           BiocParallel_1.10.1        Biobase_2.36.2             BiocGenerics_0.22.1        reshape2_1.4.3            
## [26] ggplot2_2.2.1              ruv_0.9.6                  quadprog_1.5-5             edgeR_3.18.1               limma_3.32.10             
## 
## loaded via a namespace (and not attached):
##  [1] bit64_0.9-7             splines_3.4.3           R.utils_2.6.0           assertthat_0.2.0        statmod_1.4.30          highr_0.6              
##  [7] aroma.light_3.6.0       latticeExtra_0.6-28     blob_1.1.0              GenomeInfoDbData_0.99.0 yaml_2.1.16             RSQLite_2.0            
## [13] backports_1.1.2         lattice_0.20-35         glue_1.2.0              digest_0.6.13           colorspace_1.3-2        htmltools_0.3.6        
## [19] Matrix_1.2-12           R.oo_1.21.0             plyr_1.8.4              pkgconfig_2.0.1         XML_3.98-1.9            biomaRt_2.32.1         
## [25] genefilter_1.58.1       zlibbioc_1.22.0         xtable_1.8-2            scales_0.5.0            tibble_1.3.4            annotate_1.54.0        
## [31] GenomicFeatures_1.28.5  lazyeval_0.2.1          survival_2.41-3         magrittr_1.5            memoise_1.1.0           evaluate_0.10.1        
## [37] R.methodsS3_1.7.1       hwriter_1.3.2           tools_3.4.3             formatR_1.5             munsell_0.4.3           locfit_1.5-9.1         
## [43] bindrcpp_0.2            lambda.r_1.2            AnnotationDbi_1.38.2    compiler_3.4.3          DESeq_1.28.0            rlang_0.1.6            
## [49] RCurl_1.95-4.8          labeling_0.3            bitops_1.0-6            rmarkdown_1.8           gtable_0.2.0            DBI_0.7                
## [55] R6_2.2.2                rtracklayer_1.36.6      bit_1.1-12              bindr_0.1               rprojroot_1.3-1         futile.options_1.0.0   
## [61] stringi_1.1.6           Rcpp_0.12.14            geneplotter_1.54.0